1. Gene
  2. Oxtr - oxytocin receptor Gene

Oxtr - oxytocin receptor Gene

中文名称:催产素受体

种属: Mus musculus

同用名: OTR

基因 ID: 18430 | 基因类型: protein coding

关于 Oxtr

Chromosome 6: 112,450,644-112,466,904 reverse strand.GRCm39:CM000999.3

This gene has 2 transcripts (splice variants), 265 orthologues, 16 paralogues and is associated with 14 phenotypes. Biased expression in adrenal adult (RPKM 71.9), mammary gland adult (RPKM 22.4) and 3 other tissues.

功能概要

预测该基因编码的蛋白可启动催产素受体活性;肽激素结合活性;和加压素受体活性。参与冷诱导产热的正调节。在血压正调节的上游或内部起作用。预计位于adherens junction;顶端质膜;和微绒毛。预计是质膜的组成部分。以多种结构表达,包括脂肪组织;脑;泌尿生殖系统;外皮系统;和小肠。与人类 OXTR(催产素受体)同源。 [由基因组资源联盟提供,2022 年 4 月]

Predicted to enable Oxytocin Receptor activity; peptide hormone binding activity; and Vasopressin Receptor activity. Involved in positive regulation of cold-induced thermogenesis. Acts upstream of or within positive regulation of blood pressure. Predicted to be located in adherens junction; apical plasma membrane; and microvillus. Predicted to be integral component of plasma membrane. Is expressed in several structures, including adipose tissue; brain; genitourinary system; integumental system; and small intestine. Orthologous to human OXTR (Oxytocin Receptor). [provided by Alliance of Genome Resources, Apr 2022]

Oxtr 基因产物(2)

mRNA Protein Name
NM_001081147.3 NP_001074616.1 oxytocin receptor isoform 1
NM_001410246.1 NP_001397175.1 oxytocin receptor isoform 2
基因本体论
  • 生物过程
生物过程 GO 注释 逻辑证据 参考文献 来源
acts upstream of or within positive regulation of blood pressure IGI
IGI: 通过遗传相互作用推断
12486173 MGI
involved in positive regulation of cold-induced thermogenesis IMP
IMP: 通过突变表型推断
24002032 MGI
EXP:通过实验结果推断 IDA:通过直接分析推断 IPI:通过物理相互作用推断 IMP:通过突变表型推断 IGI:通过遗传相互作用推断 IEP:通过表达模式推断

Oxtr 蛋白结构

7tmA_OT_R

7tmA_OT_R: cd15387 (39 - 338)

7tmA_OT_R

7tmA_OT_R: cd15387 (40 - 66)

7tmA_OT_R

7tmA_OT_R: cd15387 (73 - 100)

7tmA_OT_R

7tmA_OT_R: cd15387 (111 - 141)

7tmA_OT_R

7tmA_OT_R: cd15387 (151 - 172)

7tmA_OT_R

7tmA_OT_R: cd15387 (196 - 225)

7tmA_OT_R

7tmA_OT_R: cd15387 (266 - 296)

7tmA_OT_R

7tmA_OT_R: cd15387 (306 - 331)

  • 0
  • 100
  • 200
  • 300
  • 388 a.a.
蛋白主名 其他名称

oxytocin receptor

OT-R

直系同源

种属 基因名 来源 基因 ID
Homo sapiens Oxtr NCBI NCBI:5021