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  3. Pdpk1 - 3-phosphoinositide dependent protein kinase 1 Gene

Pdpk1 - 3-phosphoinositide dependent protein kinase 1 Gene

  • 基因
  • 蛋白
  • 相关产品
  • 直系同源

种属: Mus musculus

同用名: Pdk1

基因 ID: 18607 | 基因类型: protein coding

关于 Pdpk1

功能概要

Enables 3-phosphoinositide-dependent protein kinase activity. Involved in several processes, including negative regulation of cardiac muscle cell apoptotic process; regulation of mast cell degranulation; and type B pancreatic cell development. Acts upstream of or within hyperosmotic response. Located in cytoplasmic vesicle and postsynaptic density. Is expressed in several structures, including central nervous system; extraembryonic component; genitourinary system; hemolymphoid system gland; and retina. Human ortholog(s) of this gene implicated in prostate Cancer. Orthologous to several human genes including PDPK1 (3-phosphoinositide dependent protein kinase 1). [provided by Alliance of Genome Resources, Apr 2022]

Pdpk1 基因产物(3)

mRNA Protein Name
NM_001080773.2 NP_001074242.1 3-phosphoinositide-dependent protein kinase 1 isoform B
NM_001286662.1 NP_001273591.1 3-phosphoinositide-dependent protein kinase 1 isoform C
NM_011062.4 NP_035192.2 3-phosphoinositide-dependent protein kinase 1 isoform A
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables 3-phosphoinositide-dependent protein kinase activity IDA
IDA: 通过直接分析推断
10075713 MGI
enables 3-phosphoinositide-dependent protein kinase activity IMP
IMP: 通过突变表型推断
15116068 MGI
enables protein binding IPI
IPI: 通过物理相互作用推断
16337591 MGI
生物过程 GO 注释 逻辑证据 参考文献 来源
acts upstream of or within hyperosmotic response IDA
IDA: 通过直接分析推断
12783890 MGI
involved in insulin receptor signaling pathway IDA
IDA: 通过直接分析推断
19047061 MGI
involved in insulin receptor signaling pathway IMP
IMP: 通过突变表型推断
18347057 MGI
involved in insulin-like growth factor receptor signaling pathway IDA
IDA: 通过直接分析推断
23472139 MGI
involved in insulin-like growth factor receptor signaling pathway IMP
IMP: 通过突变表型推断
33377210 MGI
involved in negative regulation of cardiac muscle cell apoptotic process IMP
IMP: 通过突变表型推断
19429709 MGI
involved in negative regulation of toll-like receptor signaling pathway IMP
IMP: 通过突变表型推断
20584979 MGI
involved in regulation of endothelial cell migration IMP
IMP: 通过突变表型推断
17371830 MGI
involved in regulation of mast cell degranulation IMP
IMP: 通过突变表型推断
21063107 MGI
involved in type B pancreatic cell development IMP
IMP: 通过突变表型推断
19635472 MGI
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in cytoplasm IDA
IDA: 通过直接分析推断
12783890 MGI
located in cytoplasmic vesicle IDA
IDA: 通过直接分析推断
12783890 MGI
located in postsynaptic density IDA
IDA: 通过直接分析推断
17114649 MGI
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断
蛋白主名 其他名称

3-phosphoinositide-dependent protein kinase 1

Pkb kinase

相关产品

Pre-clinical Phase
生物活性分子 (6)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-12063 PHT-427 98.09% 否
HY-108263B (R)-3-Hydroxy Midostaurin Inhibitor / 否
HY-RS10287 PDPK1 Human Pre-designed siRNA Set A Pre-designed Set / 否
HY-W719359 PHT-427-d4 / 否
HY-RS17027 Pdpk1 Mouse Pre-designed siRNA Set A Pre-designed Set / 否
HY-RS23470 Pdpk1 Rat Pre-designed siRNA Set A Pre-designed Set / 否

直系同源

种属 基因名 来源 基因 ID
Homo sapiens Pdpk1 NCBI NCBI:5170
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