2. Gene
  3. Pfn1 - profilin 1 Gene

Pfn1 - profilin 1 Gene

  • 基因
  • 蛋白
  • 相关产品
  • 直系同源

种属: Mus musculus

同用名: Pfn

基因 ID: 18643 | 基因类型: protein coding

关于 Pfn1

功能概要

Enables small GTPase binding activity. Involved in modification of postsynaptic actin Cytoskeleton and synapse maturation. Acts upstream of or within neural tube closure and regulation of transcription by RNA polymerase II. Located in cytoplasm and nucleus. Is active in glutamatergic synapse. Is expressed in several structures, including central nervous system; heart; hemolymphoid system; liver; and lung. Human ortholog(s) of this gene implicated in amyotrophic lateral sclerosis type 18. Orthologous to human PFN1 (profilin 1). [provided by Alliance of Genome Resources, Apr 2022]

Pfn1 基因产物(1)

mRNA Protein Name
NM_011072.4 NP_035202.1 profilin-1
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables protein binding IPI
IPI: 通过物理相互作用推断
11826110 MGI
enables small GTPase binding IPI
IPI: 通过物理相互作用推断
10445846 MGI
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in modification of postsynaptic actin cytoskeleton IDA
IDA: 通过直接分析推断
26951674 MGI
involved in modification of postsynaptic actin cytoskeleton IMP
IMP: 通过突变表型推断
26951674 MGI
involved in modulation of chemical synaptic transmission IDA
IDA: 通过直接分析推断
26951674 MGI
involved in modulation of chemical synaptic transmission IMP
IMP: 通过突变表型推断
26951674 MGI
acts upstream of or within neural tube closure IGI
IGI: 通过遗传相互作用推断
10069337 MGI
acts upstream of or within regulation of transcription by RNA polymerase II IGI
IGI: 通过遗传相互作用推断
15615774 MGI
involved in synapse maturation IDA
IDA: 通过直接分析推断
26951674 MGI
involved in synapse maturation IMP
IMP: 通过突变表型推断
26951674 MGI
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in cytoplasm IDA
IDA: 通过直接分析推断
11274401 MGI
is active in glutamatergic synapse IDA
IDA: 通过直接分析推断
26951674 MGI
is active in glutamatergic synapse IMP
IMP: 通过突变表型推断
26951674 MGI
located in nucleus IDA
IDA: 通过直接分析推断
15615774 MGI
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断
蛋白主名 其他名称

profilin-1

actin binding protein

profilin I

相关产品

Pre-clinical Phase
生物活性分子 (5)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-136808 Pfn1-IN-1 99.17% 否
HY-116903 Pfn1-IN-2 / 否
HY-RS10368 PFN1 Human Pre-designed siRNA Set A Pre-designed Set / 否
HY-RS22276 Pfn1 Mouse Pre-designed siRNA Set A Pre-designed Set / 否
HY-RS28799 Pfn1 Rat Pre-designed siRNA Set A Pre-designed Set / 否

直系同源

种属 基因名 来源 基因 ID
Homo sapiens Pfn1 NCBI NCBI:5216
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