2. Gene
  3. Pfn2 - profilin 2 Gene

Pfn2 - profilin 2 Gene

  • 基因
  • 蛋白
  • 相关产品
  • 直系同源

种属: Mus musculus

同用名: Pfn

基因 ID: 18645 | 基因类型: protein coding

关于 Pfn2

功能概要

Predicted to enable ATP hydrolysis activity; actin monomer binding activity; and phosphatidylinositol-4,5-bisphosphate binding activity. Involved in several processes, including modification of postsynaptic actin cytoskeleton; negative regulation of ruffle assembly; and positive regulation of stress fiber assembly. Acts upstream of or within negative regulation of actin filament polymerization and positive regulation of actin filament polymerization. Located in glutamatergic synapse; postsynapse; and terminal bouton. Is active in Schaffer collateral - CA1 synapse and presynapse. Is expressed in several structures, including central nervous system; cornea stroma; ganglia; hemolymphoid system gland; and tooth. Orthologous to human PFN2 (profilin 2). [provided by Alliance of Genome Resources, Apr 2022]

Pfn2 基因产物(1)

mRNA Protein Name
NM_019410.3 NP_062283.1 profilin-2
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables protein binding IPI
IPI: 通过物理相互作用推断
11826110 MGI
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in modification of postsynaptic actin cytoskeleton IDA
IDA: 通过直接分析推断
26951674 MGI
involved in modification of postsynaptic actin cytoskeleton IMP
IMP: 通过突变表型推断
26951674 MGI
involved in modulation of chemical synaptic transmission IDA
IDA: 通过直接分析推断
26951674 MGI
involved in modulation of chemical synaptic transmission IMP
IMP: 通过突变表型推断
26951674 MGI
involved in negative regulation of epithelial cell migration IMP
IMP: 通过突变表型推断
23153535 MGI
involved in negative regulation of ruffle assembly IMP
IMP: 通过突变表型推断
23153535 MGI
acts upstream of or within positive regulation of actin filament polymerization IMP
IMP: 通过突变表型推断
17541406 MGI
involved in positive regulation of peptidyl-serine phosphorylation IMP
IMP: 通过突变表型推断
23153535 MGI
involved in positive regulation of stress fiber assembly IMP
IMP: 通过突变表型推断
23153535 MGI
involved in presynaptic actin cytoskeleton organization EXP
EXP: 通过实验结果推断
21976510 MGI
involved in presynaptic actin cytoskeleton organization IDA
IDA: 通过直接分析推断
21976510 MGI
involved in presynaptic actin cytoskeleton organization IMP
IMP: 通过突变表型推断
21976510 MGI
involved in presynaptic modulation of chemical synaptic transmission IDA
IDA: 通过直接分析推断
17541406 MGI
involved in presynaptic modulation of chemical synaptic transmission IMP
IMP: 通过突变表型推断
17541406 MGI
acts upstream of or within regulation of synaptic vesicle exocytosis IMP
IMP: 通过突变表型推断
17541406 MGI
细胞组分 GO 注释 逻辑证据 参考文献 来源
is active in Schaffer collateral - CA1 synapse IDA
IDA: 通过直接分析推断
17541406 MGI
is active in glutamatergic synapse IDA
IDA: 通过直接分析推断
17541406 MGI
is active in glutamatergic synapse IMP
IMP: 通过突变表型推断
17541406 MGI
is active in postsynapse IDA
IDA: 通过直接分析推断
17541406 MGI
is active in presynapse IDA
IDA: 通过直接分析推断
17541406 MGI
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断
蛋白主名 其他名称

profilin-2

profilin II

相关产品

Pre-clinical Phase
生物活性分子 (4)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS10369 PFN2 Human Pre-designed siRNA Set A Pre-designed Sets / 否
HY-RS19627 Pfn2 Mouse Pre-designed siRNA Set A Pre-designed Sets / 否
HY-RS20991 Mpeg1 Mouse Pre-designed siRNA Set A Pre-designed Sets / 否
HY-RS26123 Pfn2 Rat Pre-designed siRNA Set A Pre-designed Sets / 否

直系同源

种属 基因名 来源 基因 ID
Homo sapiens Pfn2 NCBI NCBI:5217
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