2. Gene
  3. Pitx1 - paired-like homeodomain transcription factor 1 Gene

Pitx1 - paired-like homeodomain transcription factor 1 Gene

  • 基因
  • 蛋白
  • 相关产品
  • 直系同源

种属: Mus musculus

同用名: Bft; Potx; Ptx1; P-OTX

基因 ID: 18740 | 基因类型: protein coding

关于 Pitx1

功能概要

Enables DNA-binding transcription activator activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Involved in embryonic hindlimb morphogenesis; negative regulation of transcription, DNA-templated; and positive regulation of transcription by RNA polymerase II. Acts upstream of or within animal organ development; hindlimb morphogenesis; and myoblast fate commitment. Located in cytoplasm and nucleus. Part of transcription regulator complex. Is expressed in several structures, including alimentary system; brain; embryo mesenchyme; genitourinary system; and sensory organ. Used to study clubfoot. Human ortholog(s) of this gene implicated in clubfoot. Orthologous to human PITX1 (paired like homeodomain 1). [provided by Alliance of Genome Resources, Apr 2022]

Pitx1 基因产物(1)

mRNA Protein Name
NM_011097.2 NP_035227.1 pituitary homeobox 1
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables DNA-binding transcription activator activity, RNA polymerase II-specific IDA
IDA: 通过直接分析推断
8675014 MGI
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IDA
IDA: 通过直接分析推断
8675014 MGI
enables protein binding IPI
IPI: 通过物理相互作用推断
9192866 MGI
生物过程 GO 注释 逻辑证据 参考文献 来源
acts upstream of or within branchiomeric skeletal muscle development IMP
IMP: 通过突变表型推断
17384148 MGI
acts upstream of or within cartilage development IMP
IMP: 通过突变表型推断
10101115 MGI
acts upstream of or within embryonic hindlimb morphogenesis IGI
IGI: 通过遗传相互作用推断
18231602 MGI
involved in embryonic hindlimb morphogenesis IMP
IMP: 通过突变表型推断
22071103 MGI
acts upstream of or within hindlimb morphogenesis IDA
IDA: 通过直接分析推断
15621531 MGI
acts upstream of or within hindlimb morphogenesis IMP
IMP: 通过突变表型推断
10049363 MGI
acts upstream of or within myoblast fate commitment IMP
IMP: 通过突变表型推断
17384148 MGI
involved in negative regulation of DNA-templated transcription IMP
IMP: 通过突变表型推断
21300782 MGI
acts upstream of or within pituitary gland development IMP
IMP: 通过突变表型推断
10049363 MGI
acts upstream of or within positive regulation of transcription by RNA polymerase II IDA
IDA: 通过直接分析推断
9192866 MGI
involved in positive regulation of transcription by RNA polymerase II IDA
IDA: 通过直接分析推断
8675014 MGI
acts upstream of or within positive regulation of transcription by RNA polymerase II IGI
IGI: 通过遗传相互作用推断
10431247 MGI
acts upstream of or within skeletal system development IMP
IMP: 通过突变表型推断
10101115 MGI
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in cytoplasm IDA
IDA: 通过直接分析推断
19531352 MGI
located in nucleus IDA
IDA: 通过直接分析推断
19531352 MGI
part of transcription regulator complex IDA
IDA: 通过直接分析推断
9192866 MGI
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断
蛋白主名 其他名称

pituitary homeobox 1

hindlimb-expressed homeobox protein backfoot

homeobox protein P-OTX

homeobox protein PITX1

pituitary OTX-related factor

相关产品

Pre-clinical Phase
生物活性分子 (3)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS10581 PITX1 Human Pre-designed siRNA Set A Pre-designed Set / 否
HY-RS21023 Pitx1 Mouse Pre-designed siRNA Set A Pre-designed Set / 否
HY-RS27540 Pitx1 Rat Pre-designed siRNA Set A Pre-designed Set / 否

直系同源

种属 基因名 来源 基因 ID
Homo sapiens Pitx1 NCBI NCBI:5307
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