2. Gene
  3. Pitx2 - paired-like homeodomain transcription factor 2 Gene

Pitx2 - paired-like homeodomain transcription factor 2 Gene

  • 基因
  • 蛋白
  • 相关产品
  • 直系同源

种属: Mus musculus

同用名: Brx1; Ptx2; Rieg; Brx1b; Otlx2; Munc30; 9430085M16Rik

基因 ID: 18741 | 基因类型: protein coding

关于 Pitx2

功能概要

Enables DNA-binding transcription factor activity, RNA polymerase II-specific; chromatin DNA binding activity; and sequence-specific DNA binding activity. Involved in animal organ development and left/right axis specification. Acts upstream of or within several processes, including animal organ development; circulatory system development; and embryonic hindlimb morphogenesis. Located in cytoplasm and nucleus. Part of transcription regulator complex. Is expressed in several structures, including alimentary system; central nervous system; embryo mesenchyme; genitourinary system; and musculature. Used to study Axenfeld-Rieger syndrome type 1 and glaucoma. Human ortholog(s) of this gene implicated in Arts syndrome; Axenfeld-Rieger syndrome; Axenfeld-Rieger syndrome type 1; anterior segment dysgenesis 4; and ring dermoid of cornea. Orthologous to human PITX2 (paired like homeodomain 2). [provided by Alliance of Genome Resources, Apr 2022]

Pitx2 基因产物(5)

mRNA Protein Name
NM_001042502.2 NP_001035967.1 pituitary homeobox 2 isoform c
NM_001042504.2 NP_001035969.1 pituitary homeobox 2 isoform a
NM_001286942.1 NP_001273871.1 pituitary homeobox 2 isoform d
NM_001287048.1 NP_001273977.1 pituitary homeobox 2 isoform e
NM_011098.4 NP_035228.2 pituitary homeobox 2 isoform b
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables DNA-binding transcription factor activity IDA
IDA: 通过直接分析推断
11157981 MGI
enables DNA-binding transcription factor activity, RNA polymerase II-specific IDA
IDA: 通过直接分析推断
21035439 MGI
enables chromatin DNA binding IDA
IDA: 通过直接分析推断
21035439 MGI
enables chromatin binding IDA
IDA: 通过直接分析推断
11157981 MGI
enables protein binding IPI
IPI: 通过物理相互作用推断
12464179 MGI
enables sequence-specific DNA binding IDA
IDA: 通过直接分析推断
20816801 MGI
生物过程 GO 注释 逻辑证据 参考文献 来源
acts upstream of or within Wnt signaling pathway IDA
IDA: 通过直接分析推断
12464179 MGI
acts upstream of or within anatomical structure morphogenesis IMP
IMP: 通过突变表型推断
10499585 MGI
acts upstream of or within animal organ morphogenesis IMP
IMP: 通过突变表型推断
10572050 MGI
acts upstream of or within atrial cardiac muscle tissue morphogenesis IMP
IMP: 通过突变表型推断
11493526 MGI
acts upstream of or within atrioventricular valve development IMP
IMP: 通过突变表型推断
18292603 MGI
acts upstream of or within branching involved in blood vessel morphogenesis IMP
IMP: 通过突变表型推断
12397115 MGI
acts upstream of or within cardiac muscle cell differentiation IMP
IMP: 通过突变表型推断
12397115 MGI
acts upstream of or within cardiac muscle tissue development IMP
IMP: 通过突变表型推断
16836994 MGI
involved in cardiac neural crest cell migration involved in outflow tract morphogenesis IMP
IMP: 通过突变表型推断
12464179 MGI
acts upstream of or within cell proliferation involved in outflow tract morphogenesis IMP
IMP: 通过突变表型推断
16836994 MGI
involved in deltoid tuberosity development IMP
IMP: 通过突变表型推断
18312615 MGI
acts upstream of or within determination of left/right symmetry IMP
IMP: 通过突变表型推断
10498698 MGI
involved in determination of left/right symmetry IMP
IMP: 通过突变表型推断
9708732 MGI
acts upstream of or within digestive system development IMP
IMP: 通过突变表型推断
11493526 MGI
acts upstream of or within embryonic camera-type eye development IMP
IMP: 通过突变表型推断
10498698 MGI
acts upstream of or within embryonic digestive tract morphogenesis IMP
IMP: 通过突变表型推断
21550054 MGI
involved in embryonic heart tube left/right pattern formation IMP
IMP: 通过突变表型推断
17234970 MGI
acts upstream of or within embryonic hindlimb morphogenesis IGI
IGI: 通过遗传相互作用推断
18231602 MGI
acts upstream of or within endodermal digestive tract morphogenesis IMP
IMP: 通过突变表型推断
21550054 MGI
acts upstream of or within extraocular skeletal muscle development IMP
IMP: 通过突变表型推断
16638982 MGI
acts upstream of or within heart development IGI
IGI: 通过遗传相互作用推断
16556915 MGI
acts upstream of or within heart development IMP
IMP: 通过突变表型推断
10498698 MGI
acts upstream of or within hypothalamus cell migration IMP
IMP: 通过突变表型推断
18206388 MGI
acts upstream of or within in utero embryonic development IMP
IMP: 通过突变表型推断
11493526 MGI
acts upstream of or within left lung morphogenesis IMP
IMP: 通过突变表型推断
11493526 MGI
involved in left/right axis specification IMP
IMP: 通过突变表型推断
15475956 MGI
acts upstream of or within lung development IMP
IMP: 通过突变表型推断
10498698 MGI
acts upstream of or within neuron migration IMP
IMP: 通过突变表型推断
18206388 MGI
acts upstream of or within odontogenesis IMP
IMP: 通过突变表型推断
10498698 MGI
involved in outflow tract morphogenesis IMP
IMP: 通过突变表型推断
12464179 MGI
acts upstream of or within pituitary gland development IMP
IMP: 通过突变表型推断
10498698 MGI
acts upstream of or within positive regulation of DNA binding IDA
IDA: 通过直接分析推断
21035439 MGI
acts upstream of or within positive regulation of DNA-templated transcription IMP
IMP: 通过突变表型推断
17767158 MGI
involved in positive regulation of cell population proliferation IMP
IMP: 通过突变表型推断
12464179 MGI
acts upstream of or within positive regulation of transcription by RNA polymerase II IDA
IDA: 通过直接分析推断
11157981 MGI
acts upstream of or within pulmonary myocardium development IMP
IMP: 通过突变表型推断
17823370 MGI
acts upstream of or within pulmonary vein morphogenesis IMP
IMP: 通过突变表型推断
11493526 MGI
acts upstream of or within regulation of cell migration IMP
IMP: 通过突变表型推断
12397115 MGI
acts upstream of or within regulation of cell population proliferation IMP
IMP: 通过突变表型推断
12464179 MGI
acts upstream of or within regulation of transcription by RNA polymerase II IDA
IDA: 通过直接分析推断
12464179 MGI
acts upstream of or within regulation of transcription by RNA polymerase II IGI
IGI: 通过遗传相互作用推断
20816801 MGI
acts upstream of or within skeletal muscle tissue development IMP
IMP: 通过突变表型推断
10572050 MGI
involved in spleen development IMP
IMP: 通过突变表型推断
15475956 MGI
acts upstream of or within subthalamic nucleus development IMP
IMP: 通过突变表型推断
18206388 MGI
acts upstream of or within superior vena cava morphogenesis IMP
IMP: 通过突变表型推断
11493526 MGI
acts upstream of or within vascular associated smooth muscle cell differentiation IMP
IMP: 通过突变表型推断
18458156 MGI
acts upstream of or within vasculogenesis IMP
IMP: 通过突变表型推断
18231602 MGI
acts upstream of or within ventricular cardiac muscle cell development IMP
IMP: 通过突变表型推断
18292603 MGI
acts upstream of or within ventricular septum morphogenesis IMP
IMP: 通过突变表型推断
18292603 MGI
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in cytoplasm IDA
IDA: 通过直接分析推断
19531352 MGI
located in nucleus IDA
IDA: 通过直接分析推断
10822271 MGI
part of transcription regulator complex IDA
IDA: 通过直接分析推断
12464179 MGI
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断
蛋白主名 其他名称

pituitary homeobox 2

ALL1-responsive protein ARP1

BRX1 homeoprotein

orthodenticle-like homeobox 2

paired-like homeodomain transcription factor Munc 30

solurshin

相关产品

Pre-clinical Phase
生物活性分子 (2)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS10582 PITX2 Human Pre-designed siRNA Set A Pre-designed Set / 否
HY-RS22730 Pitx2 Mouse Pre-designed siRNA Set A Pre-designed Set / 否

直系同源

种属 基因名 来源 基因 ID
Homo sapiens Pitx2 NCBI NCBI:5308
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