2. Gene
  3. Pklr - pyruvate kinase liver and red blood cell Gene

Pklr - pyruvate kinase liver and red blood cell Gene

  • 基因
  • 蛋白
  • 相关产品
  • 直系同源

种属: Mus musculus

同用名: Pk1; Pk-1; R-PK

基因 ID: 18770 | 基因类型: protein coding

关于 Pklr

功能概要

Enables Pyruvate Kinase activity. Acts upstream of or within response to Other organism. Located in cytoplasm and plasma membrane. Is expressed in several structures, including alimentary system; central nervous system; genitourinary system; respiratory system; and sensory organ. Used to study malaria and Pyruvate Kinase deficiency of red cells. Human ortholog(s) of this gene implicated in Gaucher's disease; congenital nonspherocytic hemolytic anemia; malaria; Pyruvate Kinase deficiency of red cells; and type 2 diabetes mellitus. Orthologous to human PKLR (Pyruvate Kinase L/R). [provided by Alliance of Genome Resources, Apr 2022]

Pklr 基因产物(2)

mRNA Protein Name
NM_001099779.1 NP_001093249.1 pyruvate kinase PKLR isoform 2
NM_013631.2 NP_038659.2 pyruvate kinase PKLR isoform 1
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables pyruvate kinase activity IDA
IDA: 通过直接分析推断
7295297 MGI
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in glycolytic process IDA
IDA: 通过直接分析推断
7295297 MGI
acts upstream of or within response to other organism IMP
IMP: 通过突变表型推断
14595440 MGI
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in cytoplasm IDA
IDA: 通过直接分析推断
18698006 MGI
is active in cytosol IDA
IDA: 通过直接分析推断
30150719 MGI
located in plasma membrane IDA
IDA: 通过直接分析推断
18698006 MGI
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断
蛋白主名 其他名称

pyruvate kinase PKLR

L-PK

pyruvate kinase isozymes L/R

pyruvate kinase isozymes R/L

相关产品

Approval
生物活性分子 (1)
目录号 产品名 作用方式
纯度 是否罕见病
HY-12689 Mitapivat Activator 99.84% 是
Clinical Phase
生物活性分子 (2)
目录号 产品名 作用方式
纯度 Phase
HY-12689A Mitapivat hemisulfate sesquihydrate Activator / Phase 4
HY-12689B Mitapivat hemisulfate Activator / Phase 4
Pre-clinical Phase
生物活性分子 (5)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-122682 SBI-993 98.67% 否
HY-135884 Tebapivat Activator 99.66% 否
HY-RS10601 PKLR Human Pre-designed siRNA Set A Pre-designed Set / 否
HY-RS18255 Pklr Mouse Pre-designed siRNA Set A Pre-designed Set / 否
HY-RS24735 Pklr Rat Pre-designed siRNA Set A Pre-designed Set / 否

直系同源

种属 基因名 来源 基因 ID
Homo sapiens Pklr NCBI NCBI:5313
Rattus norvegicus Pklr NCBI NCBI:24651
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