2. Gene
  3. Plcb1 - phospholipase C, beta 1 Gene

Plcb1 - phospholipase C, beta 1 Gene

  • 基因
  • 蛋白
  • 相关产品
  • 直系同源

种属: Mus musculus

同用名: Plcb; mKIAA0581; 3110043I21Rik

基因 ID: 18795 | 基因类型: protein coding

关于 Plcb1

功能概要

Enables lamin binding activity and phosphatidylinositol Phospholipase C activity. Involved in several processes, including positive regulation of cell cycle process; regulation of cellular macromolecule biosynthetic process; and regulation of trans-synaptic signaling. Located in several cellular components, including chromatin; glutamatergic synapse; and nuclear speck. Part of protein-containing complex. Is active in GABA-ergic synapse. Is expressed in several structures, including alimentary system; brain; genitourinary system; integumental system; and respiratory system. Used to study Alzheimer's disease and schizophrenia. Human ortholog(s) of this gene implicated in developmental and epileptic encephalopathy 12 and myelodysplastic syndrome. Orthologous to human PLCB1 (Phospholipase C beta 1). [provided by Alliance of Genome Resources, Apr 2022]

Plcb1 基因产物(2)

mRNA Protein Name
NM_001145830.1 NP_001139302.1 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1 isoform 1
NM_019677.2 NP_062651.2 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1 isoform 2
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables lamin binding IPI
IPI: 通过物理相互作用推断
19028838 MGI
enables phosphatidylinositol phospholipase C activity IDA
IDA: 通过直接分析推断
9762362 MGI
enables protein binding IPI
IPI: 通过物理相互作用推断
17022104 MGI
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in G protein-coupled acetylcholine receptor signaling pathway IMP
IMP: 通过突变表型推断
9305844 MGI
involved in G2/M transition of mitotic cell cycle IDA
IDA: 通过直接分析推断
19028838 MGI
involved in activation of meiosis involved in egg activation IDA
IDA: 通过直接分析推断
14499343 MGI
involved in cerebral cortex development IMP
IMP: 通过突变表型推断
11224545 MGI
involved in fat cell differentiation IDA
IDA: 通过直接分析推断
19385066 MGI
involved in glutamate receptor signaling pathway IMP
IMP: 通过突变表型推断
11224545 MGI
involved in insulin-like growth factor receptor signaling pathway IDA
IDA: 通过直接分析推断
9187110 MGI
involved in ion channel modulating, G protein-coupled receptor signaling pathway IMP
IMP: 通过突变表型推断
31268747 MGI
involved in ligand-gated ion channel signaling pathway IMP
IMP: 通过突变表型推断
26075576 MGI
involved in memory IMP
IMP: 通过突变表型推断
18493969 MGI
involved in negative regulation of DNA-templated transcription IDA
IDA: 通过直接分析推断
12031797 MGI
involved in negative regulation of monocyte extravasation IDA
IDA: 通过直接分析推断
19687358 MGI
involved in phospholipase C-activating G protein-coupled acetylcholine receptor signaling pathway IGI
IGI: 通过遗传相互作用推断
10570150 MGI
involved in phospholipase C-activating G protein-coupled acetylcholine receptor signaling pathway IMP
IMP: 通过突变表型推断
31268747 MGI
involved in phospholipase C-activating G protein-coupled receptor signaling pathway IMP
IMP: 通过突变表型推断
26075576 MGI
involved in positive regulation of CD24 production IDA
IDA: 通过直接分析推断
15849202 MGI
involved in positive regulation of DNA-templated transcription IDA
IDA: 通过直接分析推断
15849202 MGI
involved in positive regulation of G1/S transition of mitotic cell cycle IDA
IDA: 通过直接分析推断
10913438 MGI
involved in positive regulation of acrosome reaction IMP
IMP: 通过突变表型推断
11464583 MGI
involved in positive regulation of developmental growth IMP
IMP: 通过突变表型推断
15474310 MGI
involved in positive regulation of embryonic development IMP
IMP: 通过突变表型推断
11464583 MGI
involved in positive regulation of insulin secretion IGI
IGI: 通过遗传相互作用推断
10570150 MGI
involved in positive regulation of insulin secretion IMP
IMP: 通过突变表型推断
26075576 MGI
involved in positive regulation of interleukin-12 production IMP
IMP: 通过突变表型推断
9444325 MGI
involved in positive regulation of myoblast differentiation IDA
IDA: 通过直接分析推断
15174099 MGI
involved in postsynaptic modulation of chemical synaptic transmission EXP
EXP: 通过实验结果推断
16339037 MGI
involved in postsynaptic modulation of chemical synaptic transmission IDA
IDA: 通过直接分析推断
16339037 MGI
involved in postsynaptic modulation of chemical synaptic transmission IMP
IMP: 通过突变表型推断
16339037 MGI
involved in regulation of G protein-coupled receptor signaling pathway IMP
IMP: 通过突变表型推断
18493969 MGI
involved in regulation of establishment of endothelial barrier IMP
IMP: 通过突变表型推断
27653213 MGI
involved in regulation of fertilization IMP
IMP: 通过突变表型推断
11464583 MGI
involved in regulation of retrograde trans-synaptic signaling by endocanabinoid IDA
IDA: 通过直接分析推断
15664177 MGI
involved in regulation of retrograde trans-synaptic signaling by endocanabinoid IMP
IMP: 通过突变表型推断
15664177 MGI
细胞组分 GO 注释 逻辑证据 参考文献 来源
is active in GABA-ergic synapse IDA
IDA: 通过直接分析推断
15664177 MGI
is active in GABA-ergic synapse IMP
IMP: 通过突变表型推断
15664177 MGI
located in chromatin IDA
IDA: 通过直接分析推断
19028838 MGI
located in cytoplasm IDA
IDA: 通过直接分析推断
15849202 MGI
is active in glutamatergic synapse EXP
EXP: 通过实验结果推断
16339037 MGI
is active in glutamatergic synapse IDA
IDA: 通过直接分析推断
16339037 MGI
is active in glutamatergic synapse IMP
IMP: 通过突变表型推断
16339037 MGI
located in nuclear speck IDA
IDA: 通过直接分析推断
17022104 MGI
located in nucleus IDA
IDA: 通过直接分析推断
10913438 MGI
is active in postsynaptic cytosol IDA
IDA: 通过直接分析推断
18973591 MGI
is active in postsynaptic cytosol IEP
IEP: 通过表达模式推断
18973591 MGI
part of protein-containing complex IDA
IDA: 通过直接分析推断
27353086 MGI
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断
蛋白主名 其他名称

1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1

PLC-154

PLC-beta-1

phosphoinositide phospholipase C

phosphoinositide phospholipase C-beta-1

phospholipase C-beta-1a

Plcb1 抗体

目录号 产品名 应用 反应物种
HY-P81881 Phospholipase C beta 1 Antibody (YA1626) WB Rat

相关产品

Pre-clinical Phase
生物活性分子 (2)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS10652 PLCB1 Human Pre-designed siRNA Set A Pre-designed Set / 否
HY-RS21691 Plcb1 Mouse Pre-designed siRNA Set A Pre-designed Set / 否

直系同源

种属 基因名 来源 基因 ID
Homo sapiens Plcb1 NCBI NCBI:23236
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