Pparg - peroxisome proliferator activated receptor gamma Gene

中文名称：过氧化物酶体增殖物激活受体 γ

种属: Mus musculus

同用名: Nr1c3; PPARgamma; PPAR-gamma; PPARgamma2; PPAR-gamma2

关于 Pparg

功能概要

该基因编码属于过氧化物酶体增殖物激活受体 (PPAR) 家族的核受体蛋白。编码的蛋白质是配体激活的转录因子，参与脂肪细胞分化和葡萄糖稳态的调节。编码的蛋白质与类视黄醇 X 受体形成异二聚体，并与称为“过氧化物酶体增殖物反应元件”的 DNA 基序结合，以激活或抑制基因表达。由于胎盘血管形成的严重缺陷，缺乏编码蛋白的小鼠在胚胎阶段死亡。当缺乏这种基因的胚胎补充健康的胎盘时，突变体可以存活到足月，但会死于脂肪营养不良和多发性出血。可变剪接导致编码不同异构体的多个转录变体。 [RefSeq 提供，2015 年 4 月]

This gene encodes a nuclear receptor protein belonging to the Peroxisome Proliferator-activated Receptor (PPAR) family. The encoded protein is a ligand-activated transcription factor that is involved in the regulation of adipocyte differentiation and glucose homeostasis. The encoded protein forms a heterodimer with retinoid X receptors and binds to DNA motifs termed "peroxisome proliferator response elements" to either activate or inhibit gene expression. Mice lacking the encoded protein die at an embryonic stage due to severe defects in placental vascularization. When the embryos lacking this gene are supplemented with healthy placentas, the mutants survive to term, but succumb to lipodystrophy and multiple hemorrhages. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Apr 2015]