Ppargc1a - peroxisome proliferative activated receptor, gamma, coactivator 1 alpha Gene

中文名称：过氧化物酶体增殖激活受体， γ，辅激活因子 1α

种属: Mus musculus

同用名: Pgc1; PGC-1; Pgco1; Gm11133; Ppargc1; Pgc-1alpha; A830037N07Rik; PPARGC-1-alpha

关于 Ppargc1a

功能概要

该基因编码一种转录共激活因子，可诱导和协调基因表达，调节线粒体生物发生、呼吸、肝糖异生、棕色脂肪中的产热程序和肌纤维类型转换。缺乏编码蛋白的小鼠表现出产热能力降低、多动和对饮食诱导的肥胖的抵抗力。心脏中特异性缺乏编码蛋白的小鼠表现出围产期心肌病。可变剪接导致多个转录本变体。 [RefSeq 提供，2015 年 9 月]

This gene encodes a transcriptional coactivator that induces and coordinates gene expression regulating mitochondrial biogenesis, respiration, hepatic gluconeogenesis, thermogenic program in brown fat and muscle fiber-type switching. Mice lacking the encoded protein exhibit reduced thermogenic capacity, hyperactivity and resistance to diet-induced obesity. Mice lacking the encoded protein specifically in the heart exhibit peripartum cardiomyopathy. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2015]