2. Gene
  3. Prox1 - prospero homeobox 1 Gene

Prox1 - prospero homeobox 1 Gene

  • 基因
  • 蛋白
  • 相关产品
  • 直系同源

种属: Mus musculus

同用名: PROX-1; A230003G05Rik

基因 ID: 19130 | 基因类型: protein coding

关于 Prox1

功能概要

Enables DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Involved in several processes, including animal organ development; circulatory system development; and positive regulation of cell differentiation. Acts upstream of or within several processes, including animal organ development; epithelial cell differentiation; and regulation of transcription by RNA polymerase II. Located in cytoplasm and nucleus. Is expressed in several structures, including alimentary system; branchial arch; cardiovascular system; central nervous system; and eye. Used to study dilated cardiomyopathy and obesity. Orthologous to human PROX1 (prospero homeobox 1). [provided by Alliance of Genome Resources, Apr 2022]

Prox1 基因产物(2)

mRNA Protein Name
NM_001360827.1 NP_001347756.1 prospero homeobox protein 1
NM_008937.3 NP_032963.1 prospero homeobox protein 1
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables DNA-binding transcription factor activity, RNA polymerase II-specific IDA
IDA: 通过直接分析推断
16291864 MGI
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IDA
IDA: 通过直接分析推断
23723244 MGI
enables protein binding IPI
IPI: 通过物理相互作用推断
23723244 MGI
enables sequence-specific DNA binding IDA
IDA: 通过直接分析推断
21040746 MGI
生物过程 GO 注释 逻辑证据 参考文献 来源
acts upstream of or within acinar cell differentiation IMP
IMP: 通过突变表型推断
22178591 MGI
involved in aorta smooth muscle tissue morphogenesis IMP
IMP: 通过突变表型推断
19091769 MGI
involved in atrial cardiac muscle tissue morphogenesis IMP
IMP: 通过突变表型推断
19091769 MGI
acts upstream of or within blood vessel endothelial cell differentiation IMP
IMP: 通过突变表型推断
11927535 MGI
acts upstream of or within branching involved in pancreas morphogenesis IMP
IMP: 通过突变表型推断
22178591 MGI
acts upstream of cell population proliferation IMP
IMP: 通过突变表型推断
12692551 MGI
involved in cerebellar granule cell differentiation IMP
IMP: 通过突变表型推断
20808958 MGI
involved in circadian rhythm IEP
IEP: 通过表达模式推断
23723244 MGI
involved in dentate gyrus development IMP
IMP: 通过突变表型推断
20808958 MGI
involved in embryonic retina morphogenesis in camera-type eye IEP
IEP: 通过表达模式推断
12692551 MGI
involved in endocardium formation IMP
IMP: 通过突变表型推断
19091769 MGI
acts upstream of or within epithelial cell migration IMP
IMP: 通过突变表型推断
10888866 MGI
acts upstream of or within hepatocyte cell migration IMP
IMP: 通过突变表型推断
10888866 MGI
involved in hepatocyte differentiation IEP
IEP: 通过表达模式推断
15232737 MGI
acts upstream of or within hepatocyte proliferation IMP
IMP: 通过突变表型推断
10888866 MGI
acts upstream of or within inner ear development IMP
IMP: 通过突变表型推断
20186345 MGI
involved in lens fiber cell morphogenesis IMP
IMP: 通过突变表型推断
10080188 MGI
involved in lens morphogenesis in camera-type eye IMP
IMP: 通过突变表型推断
10080188 MGI
involved in lens placode formation involved in camera-type eye formation IEP
IEP: 通过表达模式推断
11850194 MGI
acts upstream of or within lymph vessel development IMP
IMP: 通过突变表型推断
16170315 MGI
acts upstream of or within lymphatic endothelial cell differentiation IMP
IMP: 通过突变表型推断
19056883 MGI
involved in negative regulation of DNA-templated transcription IDA
IDA: 通过直接分析推断
23723244 MGI
acts upstream of or within negative regulation of neuroblast proliferation IMP
IMP: 通过突变表型推断
12692551 MGI
acts upstream of or within negative regulation of transcription by RNA polymerase II IDA
IDA: 通过直接分析推断
21040746 MGI
acts upstream of neuroblast proliferation IMP
IMP: 通过突变表型推断
12692551 MGI
acts upstream of or within neuron fate determination IMP
IMP: 通过突变表型推断
12692551 MGI
involved in neuronal stem cell population maintenance IMP
IMP: 通过突变表型推断
20808958 MGI
involved in positive regulation of cell cycle IMP
IMP: 通过突变表型推断
10080188 MGI
acts upstream of or within positive regulation of cell cycle checkpoint IMP
IMP: 通过突变表型推断
21040746 MGI
involved in positive regulation of cell population proliferation IMP
IMP: 通过突变表型推断
12692551 MGI
involved in positive regulation of forebrain neuron differentiation IMP
IMP: 通过突变表型推断
20808958 MGI
involved in positive regulation of heart growth IMP
IMP: 通过突变表型推断
19091769 MGI
involved in positive regulation of neural precursor cell proliferation IMP
IMP: 通过突变表型推断
20808958 MGI
involved in positive regulation of sarcomere organization IMP
IMP: 通过突变表型推断
19091769 MGI
acts upstream of or within positive regulation of transcription by RNA polymerase II IDA
IDA: 通过直接分析推断
16291864 MGI
involved in regulation of gene expression IMP
IMP: 通过突变表型推断
10080188 MGI
involved in skeletal muscle thin filament assembly IMP
IMP: 通过突变表型推断
19091769 MGI
acts upstream of transcription by RNA polymerase II IDA
IDA: 通过直接分析推断
16291864 MGI
involved in venous blood vessel morphogenesis IMP
IMP: 通过突变表型推断
19091769 MGI
involved in ventricular cardiac muscle tissue morphogenesis IMP
IMP: 通过突变表型推断
19091769 MGI
involved in ventricular cardiac myofibril assembly IMP
IMP: 通过突变表型推断
19091769 MGI
involved in ventricular septum morphogenesis IMP
IMP: 通过突变表型推断
19091769 MGI
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in cytoplasm IDA
IDA: 通过直接分析推断
11850194 MGI
located in nucleus IDA
IDA: 通过直接分析推断
11850194 MGI
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断
蛋白主名 其他名称

prospero homeobox protein 1

homeobox prospero-like protein PROX1

prospero-related homeobox 1

相关产品

Pre-clinical Phase
生物活性分子 (4)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS11203 PROX1 Human Pre-designed siRNA Set A Pre-designed Set / 否
HY-RS19733 Prox1 Mouse Pre-designed siRNA Set A Pre-designed Set / 否
HY-RS20455 Nprl3 Mouse Pre-designed siRNA Set A Pre-designed Set / 否
HY-RS26229 Prox1 Rat Pre-designed siRNA Set A Pre-designed Set / 否

直系同源

种属 基因名 来源 基因 ID
Homo sapiens Prox1 NCBI NCBI:5629
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