2. Gene
  3. Flna - filamin, alpha Gene

Flna - filamin, alpha Gene

  • 基因
  • 蛋白
  • 相关产品
  • 直系同源

种属: Mus musculus

同用名: Fln1; Dilp2; ABP-280; GENA 379; filamin-1; F730004A14Rik

基因 ID: 192176 | 基因类型: protein coding

关于 Flna

功能概要

Enables Potassium Channel regulator activity and protein kinase C binding activity. Involved in several processes, including circulatory system development; regulation of ion transmembrane transport; and regulation of neuron projection development. Acts upstream of or within actin Cytoskeleton organization; early endosome to late endosome transport; and epithelial to mesenchymal transition. Located in several cellular components, including Z disc; axonal growth cone; and trans-Golgi network. Is expressed in several structures, including bone; brain; great vessel of heart; gut; and heart. Used to study periventricular nodular heterotopia. Human ortholog(s) of this gene implicated in X-linked recessive disease (multiple); bone development disease (multiple); heart valve disease (multiple); periventricular nodular heterotopia; and terminal osseous dysplasia. Orthologous to human FLNA (filamin A). [provided by Alliance of Genome Resources, Apr 2022]

Flna 基因产物(3)

mRNA Protein Name
NM_001290421.1 NP_001277350.1 filamin-A isoform 2
NM_001404064.1 NP_001390993.1 filamin-A isoform 3
NM_010227.3 NP_034357.2 filamin-A isoform 1
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables potassium channel regulator activity IMP
IMP: 通过突变表型推断
24951510 MGI
enables protein binding IPI
IPI: 通过物理相互作用推断
8871564 MGI
enables protein kinase C binding IDA
IDA: 通过直接分析推断
12704190 MGI
生物过程 GO 注释 逻辑证据 参考文献 来源
acts upstream of or within actin cytoskeleton organization IGI
IGI: 通过遗传相互作用推断
21709252 MGI
involved in angiogenesis IMP
IMP: 通过突变表型推断
17172441 MGI
involved in blood vessel remodeling IMP
IMP: 通过突变表型推断
17172441 MGI
involved in cell-cell junction organization IMP
IMP: 通过突变表型推断
17172441 MGI
acts upstream of or within early endosome to late endosome transport IDA
IDA: 通过直接分析推断
9412467 MGI
acts upstream of or within epithelial to mesenchymal transition IGI
IGI: 通过遗传相互作用推断
21709252 MGI
involved in heart morphogenesis IMP
IMP: 通过突变表型推断
17172441 MGI
involved in negative regulation of neuron projection development IGI
IGI: 通过遗传相互作用推断
25358863 MGI
involved in positive regulation of axon regeneration IMP
IMP: 通过突变表型推断
26157139 MGI
involved in positive regulation of potassium ion transmembrane transport IMP
IMP: 通过突变表型推断
24951510 MGI
involved in protein localization to plasma membrane IMP
IMP: 通过突变表型推断
24951510 MGI
involved in regulation of actin filament bundle assembly IMP
IMP: 通过突变表型推断
20713593 MGI
involved in regulation of membrane repolarization during cardiac muscle cell action potential IMP
IMP: 通过突变表型推断
24951510 MGI
involved in semaphorin-plexin signaling pathway IEP
IEP: 通过表达模式推断
25358863 MGI
involved in semaphorin-plexin signaling pathway IGI
IGI: 通过遗传相互作用推断
25358863 MGI
involved in synapse organization IDA
IDA: 通过直接分析推断
26972007 MGI
involved in synapse organization IMP
IMP: 通过突变表型推断
26972007 MGI
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in Z disc IDA
IDA: 通过直接分析推断
24951510 MGI
located in actin cytoskeleton IDA
IDA: 通过直接分析推断
25358863 MGI
located in actin filament bundle IDA
IDA: 通过直接分析推断
24436304 MGI
located in axonal growth cone IDA
IDA: 通过直接分析推断
26157139 MGI
located in brush border IDA
IDA: 通过直接分析推断
22114352 MGI
located in growth cone IDA
IDA: 通过直接分析推断
25358863 MGI
located in podosome IDA
IDA: 通过直接分析推断
23525008 MGI
located in trans-Golgi network IDA
IDA: 通过直接分析推断
9412467 MGI
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断
蛋白主名 其他名称

filamin-A

actin-binding protein 280

dilated pupils 2

endothelial actin-binding protein

non-muscle filamin

相关产品

Clinical Phase
生物活性分子 (3)
目录号 产品名 作用方式
纯度 Phase
HY-139142B Simufilam hydrochloride 99.85% Phase 3
HY-139142 Simufilam 98.08% Phase 3
HY-139142A Simufilam dihydrochloride / Phase 3
Pre-clinical Phase
生物活性分子 (3)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS04979 FLNA Human Pre-designed siRNA Set A Pre-designed Set / 否
HY-RS18476 Flna Mouse Pre-designed siRNA Set A Pre-designed Set / 否
HY-RS24957 Flna Rat Pre-designed siRNA Set A Pre-designed Set / 否

直系同源

种属 基因名 来源 基因 ID
Homo sapiens Flna NCBI NCBI:2316
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