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  3. Nlrp1a - NLR family, pyrin domain containing 1A Gene

Nlrp1a - NLR family, pyrin domain containing 1A Gene

  • 基因
  • 蛋白
  • 相关产品

中文名称：NLR 家族，含 pyrin 结构域 1A

种属: Mus musculus

同用名: NAC; Gm14; Gm15; CARD7; Nalp1; Nlrp1; DEFCAP; Nalp1a; PP1044

基因 ID: 195046 | 基因类型: protein coding

关于 Nlrp1a

Chromosome 11: 70,983,062-71,035,530 reverse strand.GRCm39:CM001004.3

This gene has 2 transcripts (splice variants), 88 orthologues, 22 paralogues and is associated with 37 phenotypes. Low expression observed in reference dataset.

功能概要

预计该基因编码的蛋白可启动多种功能，包括 ATP 绑定活动；半胱氨酸型内肽酶激活剂活性；和核酸结合活性。参与正向调节白细胞介素 1 β 的产生和对胞壁酰二肽的反应。在对细菌和程序性坏死细胞死亡的防御反应的上游或内部起作用。预计位于胞质溶胶和核质中。预计是 NLRP1 炎性体复合体的一部分。该基因的人类直系同源物与白斑有关。与人类 NLRP1 同源（NLR 家族 pyrin 结构域包含 1）。 [由基因组资源联盟提供，2022 年 4 月]

Predicted to enable several functions, including ATP binding activity; cysteine-type endopeptidase activator activity; and nucleic acid binding activity. Involved in positive regulation of interleukin-1 beta production and response to muramyl dipeptide. Acts upstream of or within defense response to bacterium and programmed necrotic cell death. Predicted to be located in cytosol and nucleoplasm. Predicted to be part of NLRP1 inflammasome complex. Human ortholog(s) of this gene implicated in vitiligo. Orthologous to human NLRP1 (NLR family pyrin domain containing 1). [provided by Alliance of Genome Resources, Apr 2022]

Nlrp1a 基因产物(1)

mRNA Protein Name
NM_001004142.2 NP_001004142.2 NACHT, LRR and PYD domains-containing protein 1a

Nlrp1a 蛋白结构

NACHT

NACHT: pfam05729 (132 - 298)

NOD2_WH

NOD2_WH: pfam17779 (371 - 425)

NLRC4_HD2

NLRC4_HD2: pfam17776 (427 - 539)

PPP1R42

PPP1R42: cl42388 (616 - 726)

LRR_1

LRR_1: sd00031 (634 - 662)

LRR_1

LRR_1: sd00031 (663 - 690)

LRR_RI

LRR_RI: sd00033 (720 - 741)

FIIND

FIIND: pfam13553 (819 - 1071)

CARD_ASC_NALP1

CARD_ASC_NALP1: cd08330 (1091 - 1171)

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  • 1182 a.a.
蛋白主名 其他名称

NACHT, LRR and PYD domains-containing protein 1a

NACHT, LRR and PYD containing protein 1

NACHT, leucine rich repeat and PYD containing 1

NACHT/LRR/pyrin domain-containing protein 1

NLR family, pyrin domain containing 1

NLR family, pyrin domain containing 1A, CAST/EiJ strain specific

NLR family, pyrin domain containing 1A, PWK/PhJ strain specific

NLR family, pyrin domain containing 1A, WSB/EiJ strain specific

caspase recruitment domain protein

caspase recruitment domain-containing protein 7

death effector filament-forming Ced-4-like apoptosis p

相关产品

Pre-clinical Phase
生物活性分子 (2)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS09354 Nlrp1a Mouse Pre-designed siRNA Set A Pre-designed Sets / 否
HY-RS09355 Nlrp1a Rat Pre-designed siRNA Set A Pre-designed Sets / 否
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