1. Gene
  2. Rnf4 - ring finger protein 4 Gene

Rnf4 - ring finger protein 4 Gene

种属: Mus musculus

同用名: SNURF; Gtrgeo8

基因 ID: 19822 | 基因类型: protein coding

关于 Rnf4

功能概要

This gene encodes a small nuclear RING finger protein that mediates ubiquitylation of polysumoylated proteins. Deficiency of the encoded protein in mice leads to embryonic lethality and global DNA hypermethylation. A similar protein in humans is required for arsenic-induced degradation of promyelocytic leukemia protein in acute promyelocytic leukemia. Alternative splicing of this gene results in multiple transcript variants. A pseudogene for this gene has been identified on chromosome 10. [provided by RefSeq, Jan 2015]

Rnf4 基因产物(3)

mRNA Protein Name
NM_001304269.1 NP_001291198.1 E3 ubiquitin-protein ligase RNF4
NM_001304270.1 NP_001291199.1 E3 ubiquitin-protein ligase RNF4
NM_011278.5 NP_035408.1 E3 ubiquitin-protein ligase RNF4
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables protein binding IPI
IPI: 通过物理相互作用推断
10822263 MGI
enables transcription factor binding IPI
IPI: 通过物理相互作用推断
10849425 MGI
生物过程 GO 注释 逻辑证据 参考文献 来源
acts upstream of or within positive regulation of transcription by RNA polymerase II IDA
IDA: 通过直接分析推断
10849425 MGI
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in cytoplasm IDA
IDA: 通过直接分析推断
10822263 MGI
located in nucleus IDA
IDA: 通过直接分析推断
10822263 MGI
EXP:通过实验结果推断 IDA:通过直接分析推断 IPI:通过物理相互作用推断 IMP:通过突变表型推断 IGI:通过遗传相互作用推断 IEP:通过表达模式推断
蛋白主名 其他名称

E3 ubiquitin-protein ligase RNF4

E3 ubiquitin ligase RNF4

RING-type E3 ubiquitin transferase RNF4

直系同源

种属 基因名 来源 基因 ID
Homo sapiens Rnf4 NCBI NCBI:6047
Canis familiaris Rnf4 NCBI NCBI:100855762