2. Gene
  3. Rora - RAR-related orphan receptor alpha Gene

Rora - RAR-related orphan receptor alpha Gene

  • 基因
  • 蛋白
  • 相关产品
  • 直系同源

中文名称：RAR 相关孤儿受体 alpha

种属: Mus musculus

同用名: sg; ROR1; ROR2; ROR3; Nr1f1; nmf267; tmgc26; staggerer; 9530021D13Rik

基因 ID: 19883 | 基因类型: protein coding

关于 Rora

Chromosome 9: 68,561,068-69,295,528 forward strand.GRCm39:CM001002.3

This gene has 6 transcripts (splice variants), 395 orthologues, 19 paralogues and is associated with 104 phenotypes. Broad expression in cerebellum adult (RPKM 8.5), cortex adult (RPKM 3.) and 19 other tissues.

功能概要

该基因编码的蛋白质是核激素受体 NR1 亚家族的成员。它可以作为单体或作为同型二聚体与几个基因上游的激素反应元件结合，以增强这些基因的表达。编码的蛋白质已显示与 NM23-2 相互作用，NM23-2 是一种参与器官发生和分化的核苷二磷酸激酶，以及与肿瘤转移抑制候选基因的产物 NM23-1 相互作用。此外，它已被证明有助于某些与昼夜节律有关的基因的转录调节。已发现该基因的三个转录变体编码不同的亚型。 [RefSeq 提供，2014 年 2 月]

The protein encoded by this gene is a member of the NR1 subfamily of nuclear hormone receptors. It can bind as a monomer or as a homodimer to hormone response elements upstream of several genes to enhance the expression of those genes. The encoded protein has been shown to interact with NM23-2, a nucleoside diphosphate kinase involved in organogenesis and differentiation, as well as with NM23-1, the product of a tumor metastasis suppressor candidate gene. Also, it has been shown to aid in the transcriptional regulation of some genes involved in circadian rhythm. Three transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Feb 2014]

Rora 基因产物(3)

mRNA Protein Name
NM_001289917.1 NP_001276846.1 nuclear receptor ROR-alpha isoform 3
NM_013646.2 NP_038674.1 nuclear receptor ROR-alpha isoform 1
NM_001289916.1 NP_001276845.1 nuclear receptor ROR-alpha isoform 2
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables DNA binding IDA
IDA: 通过直接分析推断
7838158 MGI
enables DNA-binding transcription factor activity IDA
IDA: 通过直接分析推断
7838156 MGI
enables DNA-binding transcription factor activity, RNA polymerase II-specific IDA
IDA: 通过直接分析推断
18164222 MGI
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IDA
IDA: 通过直接分析推断
15199055 MGI
enables beta-catenin binding IPI
IPI: 通过物理相互作用推断
14687547 MGI
enables protein binding IPI
IPI: 通过物理相互作用推断
17110330 MGI
enables sequence-specific DNA binding IDA
IDA: 通过直接分析推断
18055760 MGI
enables transcription coactivator binding IPI
IPI: 通过物理相互作用推断
17476214 MGI
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in T-helper 17 cell differentiation IMP
IMP: 通过突变表型推断
18164222 MGI
acts upstream of or within cGMP metabolic process IMP
IMP: 通过突变表型推断
7518067 MGI
acts upstream of or within cellular response to interleukin-1 IDA
IDA: 通过直接分析推断
19955433 MGI
acts upstream of or within cellular response to tumor necrosis factor IDA
IDA: 通过直接分析推断
19955433 MGI
acts upstream of or within cerebellar Purkinje cell differentiation IMP
IMP: 通过突变表型推断
8996814 MGI
involved in cerebellar granule cell precursor proliferation IMP
IMP: 通过突变表型推断
14687547 MGI
involved in cholesterol homeostasis IMP
IMP: 通过突变表型推断
18055760 MGI
involved in circadian regulation of gene expression IDA
IDA: 通过直接分析推断
22753030 MGI
involved in negative regulation of fat cell differentiation IMP
IMP: 通过突变表型推断
19324970 MGI
acts upstream of or within nitric oxide biosynthetic process IMP
IMP: 通过突变表型推断
7518067 MGI
involved in positive regulation of DNA-templated transcription IDA
IDA: 通过直接分析推断
21628546 MGI
involved in positive regulation of circadian rhythm IDA
IDA: 通过直接分析推断
22753030 MGI
acts upstream of or within positive regulation of transcription by RNA polymerase II IDA
IDA: 通过直接分析推断
15199055 MGI
acts upstream of or within positive regulation of transcription by RNA polymerase II IGI
IGI: 通过遗传相互作用推断
15199055 MGI
acts upstream of or within regulation of DNA-templated transcription IDA
IDA: 通过直接分析推断
7838156 MGI
involved in regulation of DNA-templated transcription IDA
IDA: 通过直接分析推断
18055760 MGI
involved in regulation of circadian rhythm IMP
IMP: 通过突变表型推断
23172836 MGI
involved in regulation of glucose metabolic process IMP
IMP: 通过突变表型推断
19965867 MGI
acts upstream of or within regulation of macrophage activation IMP
IMP: 通过突变表型推断
1565842 MGI
involved in regulation of smoothened signaling pathway IMP
IMP: 通过突变表型推断
14687547 MGI
involved in regulation of steroid metabolic process IMP
IMP: 通过突变表型推断
17666523 MGI
involved in regulation of transcription by RNA polymerase II IDA
IDA: 通过直接分析推断
18164222 MGI
involved in regulation of transcription by RNA polymerase II IMP
IMP: 通过突变表型推断
19324970 MGI
involved in triglyceride homeostasis IMP
IMP: 通过突变表型推断
11053433 MGI
involved in xenobiotic metabolic process IMP
IMP: 通过突变表型推断
17666523 MGI
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in nucleus IDA
IDA: 通过直接分析推断
18055760 MGI
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

Rora 蛋白结构

NR_DBD_ROR

NR_DBD_ROR: cd06968 (65 - 159)

NR_LBD_ROR_like

NR_LBD_ROR_like: cd06939 (271 - 510)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 523 a.a.
蛋白主名 其他名称

nuclear receptor ROR-alpha

RAR-related orphan receptor A

nuclear receptor RZR-alpha

nuclear receptor subfamily 1 group F member 1

retinoid-related orphan receptor-alpha

相关产品

Pre-clinical Phase
生物活性分子 (3)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS12126 RORA Human Pre-designed siRNA Set A / 否
HY-RS12127 Rora Mouse Pre-designed siRNA Set A / 否
HY-RS12128 RORA Rat Pre-designed siRNA Set A Pre-designed Set / 否

直系同源

种属 基因名 来源 基因 ID
Homo sapiens Rora NCBI NCBI:6095
嗨！很高兴为您提供帮助！

尊敬的 MCE 客户您好，
请您选择所在区域，我们将转接对应客服为您服务！

热门区域

A

B

C

F

G

H

J

L

N

Q

S

T

X

Y

Z

热 A B C F G H J L N Q S T X Y Z