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  2. ELK4 - ETS transcription factor ELK4 Gene

ELK4 - ETS transcription factor ELK4 Gene

中文名称:ETS 转录因子 ELK4

种属: Homo sapiens

同用名: SAP1

基因 ID: 2005 | 基因类型: protein coding

关于 ELK4

Cytogenetic location: 1q32.1 Genomic coordinates (GRCh38): 1:205,607,943-205,632,011 (from NCBI)

This gene has 5 transcripts (splice variants), 200 orthologues, 28 paralogues and is associated with 48 phenotypes. Ubiquitous expression in prostate (RPKM 12.4), lymph node (RPKM 7.6) and 25 other tissues.


该基因是转录因子 Ets 家族和三元复合因子 (TCF) 亚家族的成员。 TCF 亚家族的蛋白质通过与 c-fos 原癌基因启动子中的血清反应因子和血清反应元件结合形成三元复合物。该基因编码的蛋白质被激酶 MAPK1 和 MAPK8 磷酸化。已经描述了该基因的几种转录变体。[RefSeq 提供,2008 年 7 月]

This gene is a member of the Ets family of transcription factors and of the ternary complex factor (TCF) subfamily. Proteins of the TCF subfamily form a ternary complex by binding to the the serum response factor and the serum reponse element in the promoter of the c-fos proto-oncogene. The protein encoded by this gene is phosphorylated by the kinases, MAPK1 and MAPK8. Several transcript variants have been described for this gene. [provided by RefSeq, Jul 2008]

ELK4 基因产物(2)

mRNA Protein Name
NM_001973.4 NP_001964.2 ETS domain-containing protein Elk-4 isoform a
NM_021795.3 NP_068567.1 ETS domain-containing protein Elk-4 isoform b

ELK4 蛋白结构


Ets: Ets-domain (5 - 86)

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  • 200
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  • 400
  • 431 a.a.
蛋白主名 其他名称

ETS domain-containing protein Elk-4

ELK4, ETS transcription factor


种属 基因名 来源 基因 ID
Canis familiaris ELK4 VGNC VGNC:40305
Mus musculus ELK4 MGD MGI:102853
Felis catus ELK4 VGNC VGNC:61812
Macaca mulatta ELK4 VGNC VGNC:72211
Rattus norvegicus ELK4 RGD RGD:1310504
Bos taurus ELK4 VGNC VGNC:28434