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  2. Nr1h4 - nuclear receptor subfamily 1, group H, member 4 Gene

Nr1h4 - nuclear receptor subfamily 1, group H, member 4 Gene

中文名称:核受体亚家族 1 ,H 组,成员 4

种属: Mus musculus

同用名: Fxr; HRR1; RIP14; Rxrip14

基因 ID: 20186 | 基因类型: protein coding

关于 Nr1h4

Chromosome 10: 89,290,096-89,369,447 reverse strand.GRCm39:CM001003.3

This gene has 3 transcripts (splice variants), 388 orthologues, 19 paralogues and is associated with 65 phenotypes. Biased expression in large intestine adult (RPKM 22.6), liver adult (RPKM 18.8) and 1 other tissues.


该基因编码的蛋白可启动 DNA 结合转录因子活性,RNA 聚合酶 II 特异性;胆汁酸结合活性;和维甲酸 X 受体结合活性。参与多个过程,包括脂质稳态;细胞因子产生的负调节;和信号转导的调节。作用于多个过程的上游或内部,包括 Notch 信号通路;胆汁酸代谢过程;和极低密度脂蛋白颗粒重塑的负调节。预测位于常染色质和细胞核。预计是受体复合体的一部分。以多种结构表达,包括第 1 鳃弓;中枢神经系统;肝;感觉器官;和泌尿系统。用于研究肝细胞癌。该基因的人类直系同源物与肝外胆汁淤积有关;肝细胞癌;和进行性家族性肝内胆汁淤积症 5。与人类 NR1H4 同源(核受体亚家族 1 H 组成员 4)。 [由基因组资源联盟提供,2022 年 4 月]

Enables DNA-binding transcription factor activity, RNA polymerase II-specific; bile acid binding activity; and retinoid X receptor binding activity. Involved in several processes, including lipid homeostasis; negative regulation of cytokine production; and regulation of signal transduction. Acts upstream of or within several processes, including Notch signaling pathway; bile acid metabolic process; and negative regulation of very-low-density lipoprotein particle remodeling. Predicted to be located in euchromatin and nucleus. Predicted to be part of receptor complex. Is expressed in several structures, including 1st branchial arch; central nervous system; liver; sensory organ; and urinary system. Used to study hepatocellular carcinoma. Human ortholog(s) of this gene implicated in extrahepatic cholestasis; hepatocellular carcinoma; and progressive familial intrahepatic cholestasis 5. Orthologous to human NR1H4 (nuclear receptor subfamily 1 group H member 4). [provided by Alliance of Genome Resources, Apr 2022]

Nr1h4 基因产物(4)

mRNA Protein Name
NM_001385711.1 NP_001372640.1 bile acid receptor isoform 4
NM_001163700.1 NP_001157172.1 bile acid receptor isoform 1
NM_001163504.1 NP_001156976.1 bile acid receptor isoform 2
NM_009108.2 NP_033134.2 bile acid receptor isoform 3

Nr1h4 蛋白结构


NR_DBD_FXR: cd06962 (134 - 217)


NR_LBD_Fxr: cd06936 (259 - 478)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 484 a.a.
蛋白主名 其他名称

bile acid receptor

RXR-interacting protein 14

farnesoid X activated receptor

farnesol receptor HRR-1

retinoid X receptor-interacting protein 14


种属 基因名 来源 基因 ID
Homo sapiens Nr1h4 NCBI NCBI:9971