Nr1h4 - nuclear receptor subfamily 1, group H, member 4 Gene

中文名称：核受体亚家族 1 ，H 组，成员 4

种属: Mus musculus

同用名: Fxr; HRR1; RIP14; Rxrip14

关于 Nr1h4

功能概要

该基因编码的蛋白可启动 DNA 结合转录因子活性，RNA 聚合酶 II 特异性；胆汁酸结合活性；和维甲酸 X 受体结合活性。参与多个过程，包括脂质稳态；细胞因子产生的负调节；和信号转导的调节。作用于多个过程的上游或内部，包括 Notch 信号通路；胆汁酸代谢过程；和极低密度脂蛋白颗粒重塑的负调节。预测位于常染色质和细胞核。预计是受体复合体的一部分。以多种结构表达，包括第 1 鳃弓；中枢神经系统;肝;感觉器官；和泌尿系统。用于研究肝细胞癌。该基因的人类直系同源物与肝外胆汁淤积有关；肝细胞癌；和进行性家族性肝内胆汁淤积症 5。与人类 NR1H4 同源（核受体亚家族 1 H 组成员 4）。 [由基因组资源联盟提供，2022 年 4 月]

Enables DNA-binding transcription factor activity, RNA polymerase II-specific; bile acid binding activity; and retinoid X receptor binding activity. Involved in several processes, including lipid homeostasis; negative regulation of cytokine production; and regulation of signal transduction. Acts upstream of or within several processes, including Notch signaling pathway; bile acid metabolic process; and negative regulation of very-low-density lipoprotein particle remodeling. Predicted to be located in euchromatin and nucleus. Predicted to be part of receptor complex. Is expressed in several structures, including 1st branchial arch; central nervous system; liver; sensory organ; and urinary system. Used to study hepatocellular carcinoma. Human ortholog(s) of this gene implicated in extrahepatic cholestasis; hepatocellular carcinoma; and progressive familial intrahepatic cholestasis 5. Orthologous to human NR1H4 (nuclear receptor subfamily 1 group H member 4). [provided by Alliance of Genome Resources, Apr 2022]