2. Gene
  3. Atxn1 - ataxin 1 Gene

Atxn1 - ataxin 1 Gene

  • 基因
  • 蛋白
  • 相关产品
  • 直系同源

种属: Mus musculus

同用名: Atx1; Sca1; Gm10786; 2900016G23Rik

基因 ID: 20238 | 基因类型: protein coding

关于 Atxn1

功能概要

Enables RNA binding activity and chromatin binding activity. Involved in brain development; learning or memory; and social behavior. Acts upstream of or within several processes, including negative regulation of insulin-like growth factor receptor signaling pathway; regulation of transcription by RNA polymerase II; and visual learning. Located in nuclear inclusion body. Part of protein-containing complex. Is expressed in several structures, including central nervous system; early conceptus; genitourinary system; liver; and skeleton. Used to study spinocerebellar ataxia type 1. Human ortholog(s) of this gene implicated in spinocerebellar ataxia type 1. Orthologous to human ATXN1 (ataxin 1). [provided by Alliance of Genome Resources, Apr 2022]

Atxn1 基因产物(3)

mRNA Protein Name
NM_001199304.1 NP_001186233.1 ataxin-1 isoform b
NM_001199305.1 NP_001186234.1 ataxin-1 isoform a
NM_009124.6 NP_033150.2 ataxin-1 isoform b
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables POZ domain binding IPI
IPI: 通过物理相互作用推断
37261953 MGI
enables RNA binding IDA
IDA: 通过直接分析推断
15615787 MGI
enables chromatin binding IDA
IDA: 通过直接分析推断
20628574 MGI
enables protein binding IPI
IPI: 通过物理相互作用推断
17110330 MGI
生物过程 GO 注释 逻辑证据 参考文献 来源
acts upstream of or within adult locomotory behavior IMP
IMP: 通过突变表型推断
9651231 MGI
involved in brain development IMP
IMP: 通过突变表型推断
28288114 MGI
acts upstream of or within excitatory postsynaptic potential IMP
IMP: 通过突变表型推断
9651231 MGI
acts upstream of insulin-like growth factor receptor signaling pathway IMP
IMP: 通过突变表型推断
18216249 MGI
involved in learning IMP
IMP: 通过突变表型推断
28288114 MGI
acts upstream of or within lung alveolus development IGI
IGI: 通过遗传相互作用推断
22014525 MGI
involved in memory IMP
IMP: 通过突变表型推断
28288114 MGI
acts upstream of or within negative regulation of insulin-like growth factor receptor signaling pathway IMP
IMP: 通过突变表型推断
18216249 MGI
acts upstream of or within negative regulation of phosphorylation IMP
IMP: 通过突变表型推断
18216249 MGI
acts upstream of or within negative regulation of transcription by RNA polymerase II IGI
IGI: 通过遗传相互作用推断
22014525 MGI
acts upstream of phosphorylation IMP
IMP: 通过突变表型推断
18216249 MGI
acts upstream of or within positive regulation of glial cell proliferation IMP
IMP: 通过突变表型推断
20531390 MGI
acts upstream of or within positive regulation of transcription by RNA polymerase II IMP
IMP: 通过突变表型推断
18216249 MGI
involved in social behavior IMP
IMP: 通过突变表型推断
28288114 MGI
acts upstream of transcription by RNA polymerase II IGI
IGI: 通过遗传相互作用推断
22014525 MGI
acts upstream of transcription by RNA polymerase II IMP
IMP: 通过突变表型推断
18216249 MGI
acts upstream of or within visual learning IMP
IMP: 通过突变表型推断
9651231 MGI
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in nuclear inclusion body IDA
IDA: 通过直接分析推断
15615787 MGI
located in nucleus IDA
IDA: 通过直接分析推断
20531390 MGI
part of protein-containing complex IDA
IDA: 通过直接分析推断
18337722 MGI
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断
蛋白主名 其他名称

ataxin-1

spinocerebellar ataxia 1 homolog

相关产品

Pre-clinical Phase
生物活性分子 (5)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-173353 ATXN1-MED15 PPI-IN-1 / 否
HY-RS01253 ATXN1 Human Pre-designed siRNA Set A Pre-designed Set / 否
HY-RS01255 ATXN1L Human Pre-designed siRNA Set A Pre-designed Set / 否
HY-RS21490 Atxn1 Mouse Pre-designed siRNA Set A Pre-designed Set / 否
HY-RS28008 Atxn1 Rat Pre-designed siRNA Set A Pre-designed Set / 否

直系同源

种属 基因名 来源 基因 ID
Homo sapiens Atxn1 NCBI NCBI:6310
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