2. Gene
  3. Shmt1 - serine hydroxymethyltransferase 1 (soluble) Gene

Shmt1 - serine hydroxymethyltransferase 1 (soluble) Gene

  • 基因
  • 蛋白
  • 相关产品
  • 直系同源

种属: Mus musculus

同用名: Shmt; mshmt; mshmt1; mshmt2

基因 ID: 20425 | 基因类型: protein coding

关于 Shmt1

功能概要

Enables glycine hydroxymethyltransferase activity. Involved in dTMP biosynthetic process and tetrahydrofolate interconversion. Acts upstream of or within cellular response to Leukemia Inhibitory Factor. Located in nucleus. Is expressed in several structures, including alimentary system; brain ventricular layer; genitourinary system; liver and biliary system; and skin. Human ortholog(s) of this gene implicated in breast Cancer. Orthologous to human SHMT1 (serine hydroxymethyltransferase 1). [provided by Alliance of Genome Resources, Apr 2022]

Shmt1 基因产物(1)

mRNA Protein Name
NM_009171.2 NP_033197.2 serine hydroxymethyltransferase, cytosolic
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables glycine hydroxymethyltransferase activity IGI
IGI: 通过遗传相互作用推断
19513116 MGI
enables glycine hydroxymethyltransferase activity IMP
IMP: 通过突变表型推断
19513116 MGI
生物过程 GO 注释 逻辑证据 参考文献 来源
acts upstream of or within cellular response to leukemia inhibitory factor IEP
IEP: 通过表达模式推断
20439489 MGI
involved in dTMP biosynthetic process IMP
IMP: 通过突变表型推断
19513116 MGI
involved in tetrahydrofolate interconversion IMP
IMP: 通过突变表型推断
19513116 MGI
细胞组分 GO 注释 逻辑证据 参考文献 来源
is active in nucleus IDA
IDA: 通过直接分析推断
19513116 MGI
is active in nucleus IGI
IGI: 通过遗传相互作用推断
19513116 MGI
located in nucleus IMP
IMP: 通过突变表型推断
19513116 MGI
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断
蛋白主名 其他名称

serine hydroxymethyltransferase, cytosolic

glycine hydroxymethyltransferase

serine methylase

相关产品

Pre-clinical Phase
生物活性分子 (1)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-148545 SHMT-IN-3 Inhibitor ≥98.0% 否

直系同源

种属 基因名 来源 基因 ID
Homo sapiens Shmt1 NCBI NCBI:6470
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