2. Gene
  3. Six5 - sine oculis-related homeobox 5 Gene

Six5 - sine oculis-related homeobox 5 Gene

  • 基因
  • 蛋白
  • 相关产品
  • 直系同源

种属: Mus musculus

同用名: Dmahp; MDMAHP; TrexBF

基因 ID: 20475 | 基因类型: protein coding

关于 Six5

功能概要

Enables DNA-binding transcription activator activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Involved in negative regulation of skeletal muscle satellite cell proliferation; negative regulation of transcription, DNA-templated; and positive regulation of transcription by RNA polymerase II. Acts upstream of or within lens development in camera-type eye; negative regulation of cell population proliferation; and spermatid development. Located in nucleus. Is expressed in several structures, including alimentary system; brain; genitourinary system; hemolymphoid system gland; and integumental system. Human ortholog(s) of this gene implicated in branchiootorenal syndrome 2. Orthologous to human SIX5 (SIX homeobox 5). [provided by Alliance of Genome Resources, Apr 2022]

Six5 基因产物(1)

mRNA Protein Name
NM_011383.1 NP_035513.1 homeobox protein SIX5
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables DNA binding IDA
IDA: 通过直接分析推断
14966291 MGI
enables DNA-binding transcription activator activity, RNA polymerase II-specific IDA
IDA: 通过直接分析推断
20696153 MGI
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IDA
IDA: 通过直接分析推断
8814301 MGI
enables sequence-specific DNA binding IDA
IDA: 通过直接分析推断
8814301 MGI
生物过程 GO 注释 逻辑证据 参考文献 来源
acts upstream of Leydig cell proliferation IMP
IMP: 通过突变表型推断
15163633 MGI
acts upstream of cell population proliferation IMP
IMP: 通过突变表型推断
15163633 MGI
acts upstream of or within lens development in camera-type eye IMP
IMP: 通过突变表型推断
10802667 MGI
involved in negative regulation of DNA-templated transcription IDA
IDA: 通过直接分析推断
20696153 MGI
acts upstream of or within negative regulation of cell population proliferation IMP
IMP: 通过突变表型推断
15163633 MGI
involved in negative regulation of skeletal muscle satellite cell proliferation IMP
IMP: 通过突变表型推断
20696153 MGI
involved in positive regulation of transcription by RNA polymerase II IDA
IDA: 通过直接分析推断
20696153 MGI
acts upstream of or within spermatid development IMP
IMP: 通过突变表型推断
15163633 MGI
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in nucleus IDA
IDA: 通过直接分析推断
8814301 MGI
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断
蛋白主名 其他名称

homeobox protein SIX5

DM locus-associated homeodomain protein homolog

sine oculis homeobox homolog 5

sine oculis-related homeobox 5 homolog

相关产品

Pre-clinical Phase
生物活性分子 (3)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS12962 SIX5 Human Pre-designed siRNA Set A Pre-designed Set / 否
HY-RS21435 Six5 Mouse Pre-designed siRNA Set A Pre-designed Set / 否
HY-RS27953 Six5 Rat Pre-designed siRNA Set A Pre-designed Set / 否

直系同源

种属 基因名 来源 基因 ID
Homo sapiens Six5 NCBI NCBI:147912
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