2. Gene
  3. Slc12a3 - solute carrier family 12, member 3 Gene

Slc12a3 - solute carrier family 12, member 3 Gene

  • 基因
  • 蛋白
  • 相关产品
  • 直系同源

种属: Mus musculus

同用名: NCC; TSC; NCCT

基因 ID: 20497 | 基因类型: protein coding

关于 Slc12a3

功能概要

Enables sodium ion transmembrane transporter activity. Involved in sodium ion transport. Located in apical plasma membrane and cytosol. Is expressed in metanephros. Used to study Gitelman syndrome. Human ortholog(s) of this gene implicated in Gitelman syndrome and essential hypertension. Orthologous to human SLC12A3 (solute carrier family 12 member 3). [provided by Alliance of Genome Resources, Apr 2022]

Slc12a3 基因产物(2)

mRNA Protein Name
NM_001205311.1 NP_001192240.1 solute carrier family 12 member 3 isoform 1
NM_019415.2 NP_062288.2 solute carrier family 12 member 3 isoform 2
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables protein binding IPI
IPI: 通过物理相互作用推断
26099046 MGI
enables sodium ion transmembrane transporter activity IDA
IDA: 通过直接分析推断
10516289 MGI
enables sodium:chloride symporter activity IDA
IDA: 通过直接分析推断
15068971 MGI
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in protein phosphorylation IDA
IDA: 通过直接分析推断
22846565 MGI
involved in response to aldosterone IDA
IDA: 通过直接分析推断
19690383 MGI
involved in response to dietary excess IDA
IDA: 通过直接分析推断
22846565 MGI
involved in signal transduction IMP
IMP: 通过突变表型推断
22846565 MGI
involved in sodium ion transmembrane transport IDA
IDA: 通过直接分析推断
24026181 MGI
involved in sodium ion transport IMP
IMP: 通过突变表型推断
10516289 MGI
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in apical plasma membrane IDA
IDA: 通过直接分析推断
11423561 MGI
located in cytosol IDA
IDA: 通过直接分析推断
10516289 MGI
is active in plasma membrane IDA
IDA: 通过直接分析推断
36370249 MGI
located in plasma membrane IDA
IDA: 通过直接分析推断
10516289 MGI
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断
蛋白主名 其他名称

solute carrier family 12 member 3

Na-Cl symporter

thiazide-sensitive sodium-chloride cotransporter

相关产品

Pre-clinical Phase
生物活性分子 (4)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-B1477 Clopamide Inhibitor ≥99.0% 否
HY-RS12998 SLC12A3 Human Pre-designed siRNA Set A Pre-designed Set / 否
HY-RS18580 Slc12a3 Mouse Pre-designed siRNA Set A Pre-designed Set / 否
HY-RS25065 Slc12a3 Rat Pre-designed siRNA Set A Pre-designed Set / 否

直系同源

种属 基因名 来源 基因 ID
Homo sapiens Slc12a3 NCBI NCBI:6559
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