2. Gene
  3. Slc1a3 - solute carrier family 1 (glial high affinity glutamate transporter), member 3 Gene

Slc1a3 - solute carrier family 1 (glial high affinity glutamate transporter), member 3 Gene

  • 基因
  • 蛋白
  • 相关产品
  • 直系同源

种属: Mus musculus

同用名: Gmt1; Eaat1; GLAST; GLU-T; GluT-1; MGluT1; GLAST-1; B430115D02Rik

基因 ID: 20512 | 基因类型: protein coding

关于 Slc1a3

功能概要

Enables glutamate binding activity and high-affinity glutamate transmembrane transporter activity. Involved in D-aspartate import across plasma membrane and cellular response to cocaine. Acts upstream of or within several processes, including L-glutamate import across plasma membrane; gamma-aminobutyric acid biosynthetic process; and nervous system development. Located in several cellular components, including cell surface; neuron projection; and neuronal cell body. Is integral component of plasma membrane. Is expressed in several structures, including brain; connective tissue; eye; genitourinary system; and spinal cord. Used to study low tension glaucoma. Human ortholog(s) of this gene implicated in episodic ataxia type 6. Orthologous to human SLC1A3 (solute carrier family 1 member 3). [provided by Alliance of Genome Resources, Apr 2022]

Slc1a3 基因产物(1)

mRNA Protein Name
NM_148938.3 NP_683740.1 excitatory amino acid transporter 1
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables acidic amino acid transmembrane transporter activity IMP
IMP: 通过突变表型推断
28032905 MGI
enables amino acid binding IDA
IDA: 通过直接分析推断
7903437 MGI
enables glutamate binding IDA
IDA: 通过直接分析推断
7903437 MGI
enables high-affinity L-glutamate transmembrane transporter activity IDA
IDA: 通过直接分析推断
7903437 MGI
enables high-affinity L-glutamate transmembrane transporter activity IMP
IMP: 通过突变表型推断
15390100 MGI
enables protein binding IPI
IPI: 通过物理相互作用推断
14723703 MGI
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in D-aspartate import across plasma membrane IMP
IMP: 通过突变表型推断
28032905 MGI
acts upstream of or within L-glutamate import IMP
IMP: 通过突变表型推断
15390100 MGI
acts upstream of or within L-glutamate import across plasma membrane IMP
IMP: 通过突变表型推断
15140926 MGI
acts upstream of or within L-glutamate transmembrane transport IDA
IDA: 通过直接分析推断
14723703 MGI
acts upstream of or within auditory behavior IMP
IMP: 通过突变表型推断
11102482 MGI
acts upstream of or within cell morphogenesis involved in neuron differentiation IMP
IMP: 通过突变表型推断
9753165 MGI
involved in cellular response to cocaine IDA
IDA: 通过直接分析推断
27208619 MGI
acts upstream of or within cranial nerve development IMP
IMP: 通过突变表型推断
9753165 MGI
acts upstream of or within gamma-aminobutyric acid biosynthetic process IMP
IMP: 通过突变表型推断
15305132 MGI
acts upstream of or within intracellular sodium ion homeostasis IMP
IMP: 通过突变表型推断
19766171 MGI
acts upstream of or within neuromuscular process controlling balance IMP
IMP: 通过突变表型推断
9753165 MGI
acts upstream of or within positive regulation of synaptic transmission IMP
IMP: 通过突变表型推断
9539795 MGI
acts upstream of or within response to antibiotic IMP
IMP: 通过突变表型推断
15862894 MGI
acts upstream of or within response to light stimulus IMP
IMP: 通过突变表型推断
9539795 MGI
acts upstream of or within response to wounding IMP
IMP: 通过突变表型推断
9753165 MGI
acts upstream of or within response to xenobiotic stimulus IMP
IMP: 通过突变表型推断
9539795 MGI
acts upstream of or within sensory perception of sound IMP
IMP: 通过突变表型推断
11102482 MGI
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in cell periphery IDA
IDA: 通过直接分析推断
20531390 MGI
located in cell projection IDA
IDA: 通过直接分析推断
9671661 MGI
located in cell surface IDA
IDA: 通过直接分析推断
14723703 MGI
located in neuron projection IDA
IDA: 通过直接分析推断
20531390 MGI
located in neuronal cell body IDA
IDA: 通过直接分析推断
9364068 MGI
located in plasma membrane IDA
IDA: 通过直接分析推断
14723703 MGI
located in synapse IDA
IDA: 通过直接分析推断
12558972 MGI
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断
蛋白主名 其他名称

excitatory amino acid transporter 1

glial high affinity glutamate transporter

glutamate/aspartate transporter

high-affinity neuronal glutamate transporter

sodium-dependent glutamate/aspartate transporter 1

solute carrier family 1, member 3

相关产品

Pre-clinical Phase
生物活性分子 (3)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS13054 SLC1A3 Human Pre-designed siRNA Set A Pre-designed Set / 否
HY-RS19528 Slc1a3 Mouse Pre-designed siRNA Set A Pre-designed Set / 否
HY-RS26023 Slc1a3 Rat Pre-designed siRNA Set A Pre-designed Set / 否

直系同源

种属 基因名 来源 基因 ID
Homo sapiens Slc1a3 NCBI NCBI:6507
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