2. Gene
  3. Sox18 - SRY (sex determining region Y)-box 18 Gene

Sox18 - SRY (sex determining region Y)-box 18 Gene

  • 基因
  • 蛋白
  • 相关产品
  • 直系同源

种属: Mus musculus

同用名: Ra; Ragl

基因 ID: 20672 | 基因类型: protein coding

关于 Sox18

功能概要

Enables DNA-binding transcription factor activity, RNA polymerase II-specific and transcription cis-regulatory region binding activity. Acts upstream of or within several processes, including circulatory system development; regulation of transcription, DNA-templated; and stem cell fate specification. Located in nucleus. Part of transcription regulator complex. Is expressed in several structures, including alimentary system; brain; immune system; reproductive system; and urinary system. Human ortholog(s) of this gene implicated in hypotrichosis-lymphedema-telangiectasia syndrome and hypotrichosis-lymphedema-telangiectasia-renal defect syndrome. Orthologous to human SOX18 (SRY-box transcription factor 18). [provided by Alliance of Genome Resources, Apr 2022]

Sox18 基因产物(1)

mRNA Protein Name
NM_009236.2 NP_033262.2 transcription factor SOX-18
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables DNA binding IDA
IDA: 通过直接分析推断
12446692 MGI
enables DNA-binding transcription factor activity IDA
IDA: 通过直接分析推断
7651823 MGI
enables DNA-binding transcription factor activity, RNA polymerase II-specific IDA
IDA: 通过直接分析推断
22344693 MGI
enables protein binding IPI
IPI: 通过物理相互作用推断
11554755 MGI
enables sequence-specific DNA binding IDA
IDA: 通过直接分析推断
7651823 MGI
enables transcription cis-regulatory region binding IDA
IDA: 通过直接分析推断
14634005 MGI
生物过程 GO 注释 逻辑证据 参考文献 来源
acts upstream of or within angiogenesis IGI
IGI: 通过遗传相互作用推断
16895970 MGI
acts upstream of or within blood vessel development IMP
IMP: 通过突变表型推断
10742113 MGI
acts upstream of or within cell maturation IDA
IDA: 通过直接分析推断
20228271 MGI
acts upstream of or within embryonic heart tube development IGI
IGI: 通过遗传相互作用推断
17610846 MGI
acts upstream of or within endocardial cell differentiation IGI
IGI: 通过遗传相互作用推断
17610846 MGI
acts upstream of or within endocardium formation IGI
IGI: 通过遗传相互作用推断
17610846 MGI
acts upstream of or within hair follicle development IMP
IMP: 通过突变表型推断
10742113 MGI
NOT acts upstream of or within heart development IMP
IMP: 通过突变表型推断
11094083 MGI
acts upstream of or within heart development IMP
IMP: 通过突变表型推断
10742113 MGI
NOT acts upstream of or within in utero embryonic development IMP
IMP: 通过突变表型推断
11094083 MGI
acts upstream of or within in utero embryonic development IMP
IMP: 通过突变表型推断
10742113 MGI
acts upstream of or within lymph vessel development IMP
IMP: 通过突变表型推断
291594 MGI
acts upstream of or within lymphangiogenesis IMP
IMP: 通过突变表型推断
18931657 MGI
acts upstream of or within lymphatic endothelial cell differentiation IMP
IMP: 通过突变表型推断
18931657 MGI
acts upstream of or within negative regulation of DNA-templated transcription IDA
IDA: 通过直接分析推断
18931657 MGI
acts upstream of or within positive regulation of DNA-templated transcription IDA
IDA: 通过直接分析推断
7651823 MGI
involved in positive regulation of DNA-templated transcription IDA
IDA: 通过直接分析推断
11554755 MGI
acts upstream of or within regulation of DNA-templated transcription IDA
IDA: 通过直接分析推断
12446692 MGI
acts upstream of or within regulation of stem cell proliferation IDA
IDA: 通过直接分析推断
20228271 MGI
acts upstream of or within stem cell fate specification IDA
IDA: 通过直接分析推断
20228271 MGI
acts upstream of or within vasculature development IMP
IMP: 通过突变表型推断
19429912 MGI
acts upstream of or within vasculogenesis IGI
IGI: 通过遗传相互作用推断
16895970 MGI
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in nucleus IDA
IDA: 通过直接分析推断
11554755 MGI
part of transcription regulator complex IDA
IDA: 通过直接分析推断
22344693 MGI
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断
蛋白主名 其他名称

transcription factor SOX-18

SRY-box containing gene 18

Sry-related HMG-box gene 18

ragged

相关产品

Pre-clinical Phase
生物活性分子 (4)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-116940 Sm4 Inhibitor 99.37% 否
HY-RS13590 SOX18 Human Pre-designed siRNA Set A Pre-designed Sets / 否
HY-RS20494 Sox18 Mouse Pre-designed siRNA Set A Pre-designed Sets / 否
HY-RS27002 Sox18 Rat Pre-designed siRNA Set A Pre-designed Sets / 否

直系同源

种属 基因名 来源 基因 ID
Homo sapiens Sox18 NCBI NCBI:54345
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