2. Gene
  3. Sox4 - SRY (sex determining region Y)-box 4 Gene

Sox4 - SRY (sex determining region Y)-box 4 Gene

  • 基因
  • 蛋白
  • 相关产品
  • 直系同源

种属: Mus musculus

同用名: Sox-4

基因 ID: 20677 | 基因类型: protein coding

关于 Sox4

功能概要

Enables DNA-binding transcription activator activity, RNA polymerase II-specific; RNA polymerase II cis-regulatory region sequence-specific DNA binding activity; and miRNA binding activity. Involved in several processes, including animal organ development; nervous system development; and positive regulation of cell communication. Acts upstream of or within endocrine pancreas development; hematopoietic stem cell homeostasis; and somatic stem cell population maintenance. Located in nucleus. Part of transcription regulator complex. Is active in cytoplasm. Is expressed in several structures, including alimentary system; central nervous system; genitourinary system; hindlimb long bone; and sensory organ. Human ortholog(s) of this gene implicated in Coffin-Siris syndrome and urinary bladder Cancer. Orthologous to human SOX4 (SRY-box transcription factor 4). [provided by Alliance of Genome Resources, Apr 2022]

Sox4 基因产物(2)

mRNA Protein Name
NM_009238.3 NP_033264.2 transcription factor SOX-4
NM_009238.3 NP_033264.2 transcription factor SOX-4
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables DNA binding IDA
IDA: 通过直接分析推断
18403418 MGI
enables DNA-binding transcription activator activity, RNA polymerase II-specific IDA
IDA: 通过直接分析推断
18505825 MGI
enables DNA-binding transcription factor activity IDA
IDA: 通过直接分析推断
21527504 MGI
enables DNA-binding transcription factor activity, RNA polymerase II-specific IDA
IDA: 通过直接分析推断
22344693 MGI
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IDA
IDA: 通过直接分析推断
20596238 MGI
enables miRNA binding IDA
IDA: 通过直接分析推断
26802803 MGI
enables protein binding IPI
IPI: 通过物理相互作用推断
17875931 MGI
enables transcription cis-regulatory region binding IDA
IDA: 通过直接分析推断
18505825 MGI
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in T cell differentiation IMP
IMP: 通过突变表型推断
9174623 MGI
involved in ascending aorta morphogenesis IMP
IMP: 通过突变表型推断
16109771 MGI
involved in atrial septum primum morphogenesis IMP
IMP: 通过突变表型推断
16109771 MGI
involved in cardiac right ventricle morphogenesis IMP
IMP: 通过突变表型推断
16109771 MGI
involved in cellular response to glucose stimulus IMP
IMP: 通过突变表型推断
18477811 MGI
acts upstream of or within endocrine pancreas development IMP
IMP: 通过突变表型推断
16306355 MGI
involved in gene expression IDA
IDA: 通过直接分析推断
31281513 MGI
involved in glial cell development IMP
IMP: 通过突变表型推断
20147379 MGI
involved in glial cell proliferation IMP
IMP: 通过突变表型推断
20147379 MGI
involved in glucose homeostasis IMP
IMP: 通过突变表型推断
18477811 MGI
involved in heart development IMP
IMP: 通过突变表型推断
8614465 MGI
acts upstream of or within hematopoietic stem cell homeostasis IMP
IMP: 通过突变表型推断
26880577 MGI
involved in kidney morphogenesis IMP
IMP: 通过突变表型推断
16109771 MGI
involved in mesenchyme development IMP
IMP: 通过突变表型推断
20596238 MGI
involved in mitral valve morphogenesis IMP
IMP: 通过突变表型推断
16109771 MGI
involved in nervous system development IMP
IMP: 通过突变表型推断
20596238 MGI
involved in neuroepithelial cell differentiation IMP
IMP: 通过突变表型推断
20646169 MGI
involved in noradrenergic neuron differentiation IMP
IMP: 通过突变表型推断
20147379 MGI
involved in positive regulation of DNA-templated transcription IDA
IDA: 通过直接分析推断
20596238 MGI
involved in positive regulation of canonical Wnt signaling pathway IDA
IDA: 通过直接分析推断
17875931 MGI
involved in positive regulation of canonical Wnt signaling pathway IMP
IMP: 通过突变表型推断
17875931 MGI
involved in positive regulation of gamma-delta T cell differentiation IMP
IMP: 通过突变表型推断
23562159 MGI
involved in positive regulation of insulin secretion IMP
IMP: 通过突变表型推断
18477811 MGI
involved in positive regulation of myoblast differentiation IDA
IDA: 通过直接分析推断
26291311 MGI
involved in positive regulation of transcription by RNA polymerase II IDA
IDA: 通过直接分析推断
18403418 MGI
involved in pro-B cell differentiation IMP
IMP: 通过突变表型推断
8614465 MGI
involved in protein stabilization IMP
IMP: 通过突变表型推断
17875931 MGI
involved in regulation of DNA-templated transcription IMP
IMP: 通过突变表型推断
23562159 MGI
acts upstream of or within somatic stem cell population maintenance IDA
IDA: 通过直接分析推断
19379700 MGI
involved in spinal cord development IMP
IMP: 通过突变表型推断
20646169 MGI
involved in sympathetic nervous system development IMP
IMP: 通过突变表型推断
20147379 MGI
involved in ventricular septum morphogenesis IMP
IMP: 通过突变表型推断
16109771 MGI
细胞组分 GO 注释 逻辑证据 参考文献 来源
is active in cytoplasm IDA
IDA: 通过直接分析推断
26802803 MGI
located in nucleus IDA
IDA: 通过直接分析推断
15645444 MGI
part of transcription regulator complex IDA
IDA: 通过直接分析推断
22344693 MGI
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断
蛋白主名 其他名称

transcription factor SOX-4

SRY-box containing gene 4

相关产品

Pre-clinical Phase
生物活性分子 (3)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS13595 SOX4 Human Pre-designed siRNA Set A Pre-designed Set / 否
HY-RS17375 Sox4 Mouse Pre-designed siRNA Set A Pre-designed Set / 否
HY-RS23829 Sox4 Rat Pre-designed siRNA Set A Pre-designed Set / 否

直系同源

种属 基因名 来源 基因 ID
Homo sapiens Sox4 NCBI NCBI:6659
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