2. Gene
  3. Tap2 - transporter 2, ATP-binding cassette, sub-family B (MDR/TAP) Gene

Tap2 - transporter 2, ATP-binding cassette, sub-family B (MDR/TAP) Gene

  • 基因
  • 蛋白
  • 相关产品
  • 直系同源

种属: Mus musculus

同用名: Y1; jas; APT2; Ham2; MTP2; PSF2; ABC18; Abcb3; Ham-2; Tap-2; RING11

基因 ID: 21355 | 基因类型: protein coding

关于 Tap2

功能概要

The membrane-associated protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the MDR/TAP subfamily. Members of the MDR/TAP subfamily are involved in multidrug resistance. The protein encoded by this gene is involved in antigen presentation. This protein forms a heterodimer with Tap1 in order to transport peptides from the cytoplasm to the endoplasmic reticulum. Mutations in the human gene may be associated with ankylosing spondylitis, insulin-dependent diabetes mellitus, and celiac disease. [provided by RefSeq, Jul 2008]

Tap2 基因产物(1)

mRNA Protein Name
NM_011530.3 NP_035660.3 antigen peptide transporter 2
基因本体论
  • 分子功能
  • 生物过程
分子功能 GO 注释 逻辑证据 参考文献 来源
enables TAP1 binding IPI
IPI: 通过物理相互作用推断
11133832 MGI
enables protein binding IPI
IPI: 通过物理相互作用推断
14735325 MGI
生物过程 GO 注释 逻辑证据 参考文献 来源
acts upstream of T cell mediated cytotoxicity IDA
IDA: 通过直接分析推断
1538753 MGI
acts upstream of T cell mediated cytotoxicity IMP
IMP: 通过突变表型推断
16299293 MGI
acts upstream of or within antigen processing and presentation of endogenous peptide antigen via MHC class I via ER pathway, TAP-dependent IDA
IDA: 通过直接分析推断
1538753 MGI
acts upstream of or within antigen processing and presentation of endogenous peptide antigen via MHC class Ib via ER pathway, TAP-dependent IDA
IDA: 通过直接分析推断
1538753 MGI
acts upstream of or within antigen processing and presentation of exogenous protein antigen via MHC class Ib, TAP-dependent IMP
IMP: 通过突变表型推断
16299293 MGI
acts upstream of or within positive regulation of T cell mediated cytotoxicity IDA
IDA: 通过直接分析推断
1538753 MGI
acts upstream of or within positive regulation of T cell mediated cytotoxicity IMP
IMP: 通过突变表型推断
16299293 MGI
acts upstream of or within response to molecule of bacterial origin IMP
IMP: 通过突变表型推断
16299293 MGI
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断
蛋白主名 其他名称

antigen peptide transporter 2

ATP dependent transport protein family member

ATP-binding cassette sub-family B member 3

ATP-binding cassette, sub-family B (MDR/TAP), member 3

histocompatibility antigen modifier 2

transporter 2 ATP-binding cassette sub-family B

transporter 2, ABC (

相关产品

Pre-clinical Phase
生物活性分子 (5)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS12608 SEC14L3 Human Pre-designed siRNA Set A Pre-designed Set / 否
HY-RS14202 TAP2 Human Pre-designed siRNA Set A Pre-designed Set / 否
HY-RS18500 Tap2 Mouse Pre-designed siRNA Set A Pre-designed Set / 否
HY-RS24053 Tap1 Rat Pre-designed siRNA Set A Pre-designed Set / 否
HY-RS24982 Tap2 Rat Pre-designed siRNA Set A Pre-designed Set / 否

直系同源

种属 基因名 来源 基因 ID
Homo sapiens Tap2 NCBI NCBI:6891
嗨！很高兴为您提供帮助！

尊敬的 MCE 客户您好，
请您选择所在区域，我们将转接对应客服为您服务！

热门区域

A

B

C

F

G

H

J

L

N

Q

S

T

X

Y

Z

热 A B C F G H J L N Q S T X Y Z