2. Gene
  3. Tbx2 - T-box 2 Gene

Tbx2 - T-box 2 Gene

  • 基因
  • 蛋白
  • 相关产品
  • 直系同源

种属: Mus musculus

基因 ID: 21385 | 基因类型: protein coding

关于 Tbx2

功能概要

Enables DNA binding activity and DNA-binding transcription factor activity. Involved in several processes, including circulatory system development; embryonic morphogenesis; and negative regulation of heart looping. Acts upstream of or within several processes, including animal organ development; muscle cell fate determination; and ureteric peristalsis. Located in nucleus. Part of transcription regulator complex. Is expressed in several structures, including central nervous system; embryo mesenchyme; genitourinary system; heart; and sensory organ. Human ortholog(s) of this gene implicated in vertebral anomalies and variable endocrine and T-cell dysfunction. Orthologous to human TBX2 (T-box transcription factor 2). [provided by Alliance of Genome Resources, Apr 2022]

Tbx2 基因产物(1)

mRNA Protein Name
NM_009324.2 NP_033350.2 T-box transcription factor TBX2
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables DNA binding IDA
IDA: 通过直接分析推断
15843407 MGI
enables DNA-binding transcription factor activity IDA
IDA: 通过直接分析推断
15843407 MGI
enables DNA-binding transcription factor binding IPI
IPI: 通过物理相互作用推断
33795231 MGI
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IDA
IDA: 通过直接分析推断
9710594 MGI
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IMP
IMP: 通过突变表型推断
26486273 MGI
enables histone deacetylase binding IPI
IPI: 通过物理相互作用推断
33795231 MGI
enables protein binding IPI
IPI: 通过物理相互作用推断
12023302 MGI
生物过程 GO 注释 逻辑证据 参考文献 来源
acts upstream of or within Notch signaling pathway IDA
IDA: 通过直接分析推断
23117660 MGI
involved in aorta morphogenesis IMP
IMP: 通过突变表型推断
15459098 MGI
involved in apoptotic process IMP
IMP: 通过突变表型推断
33795231 MGI
involved in atrioventricular canal development IGI
IGI: 通过遗传相互作用推断
22130515 MGI
involved in atrioventricular canal development IMP
IMP: 通过突变表型推断
15459098 MGI
involved in atrioventricular canal morphogenesis IGI
IGI: 通过遗传相互作用推断
22130515 MGI
involved in cardiac muscle cell myoblast differentiation IDA
IDA: 通过直接分析推断
15459098 MGI
acts upstream of or within cardiac muscle tissue development IMP
IMP: 通过突变表型推断
15459098 MGI
acts upstream of or within cellular senescence IDA
IDA: 通过直接分析推断
11748239 MGI
involved in cochlea morphogenesis IMP
IMP: 通过突变表型推断
33795231 MGI
acts upstream of or within developmental growth involved in morphogenesis IMP
IMP: 通过突变表型推断
19769959 MGI
involved in embryonic camera-type eye morphogenesis IMP
IMP: 通过突变表型推断
15459098 MGI
involved in embryonic digit morphogenesis IMP
IMP: 通过突变表型推断
15459098 MGI
involved in endocardial cushion morphogenesis IMP
IMP: 通过突变表型推断
15459098 MGI
involved in epithelial tube branching involved in lung morphogenesis IGI
IGI: 通过遗传相互作用推断
27720610 MGI
involved in fibroblast growth factor receptor signaling pathway IMP
IMP: 通过突变表型推断
33795231 MGI
acts upstream of or within heart morphogenesis IMP
IMP: 通过突变表型推断
15459098 MGI
acts upstream of or within mammary placode formation IGI
IGI: 通过遗传相互作用推断
16222716 MGI
involved in melanocyte proliferation IMP
IMP: 通过突变表型推断
26486273 MGI
involved in mesenchymal cell proliferation involved in lung development IMP
IMP: 通过突变表型推断
27720610 MGI
acts upstream of or within muscle cell fate determination IMP
IMP: 通过突变表型推断
15459098 MGI
acts upstream of or within negative regulation of DNA-templated transcription IDA
IDA: 通过直接分析推断
11748239 MGI
involved in negative regulation of cardiac chamber formation IMP
IMP: 通过突变表型推断
15042700 MGI
involved in negative regulation of heart looping IMP
IMP: 通过突变表型推断
15042700 MGI
acts upstream of or within negative regulation of transcription by RNA polymerase II IDA
IDA: 通过直接分析推断
12023302 MGI
involved in negative regulation of transcription by RNA polymerase II IDA
IDA: 通过直接分析推断
9710594 MGI
acts upstream of or within negative regulation of transcription by RNA polymerase II IGI
IGI: 通过遗传相互作用推断
18285513 MGI
involved in negative regulation of transcription by RNA polymerase II IMP
IMP: 通过突变表型推断
26971330 MGI
involved in neurogenesis IMP
IMP: 通过突变表型推断
33795231 MGI
involved in outflow tract morphogenesis IMP
IMP: 通过突变表型推断
15042700 MGI
involved in outflow tract septum morphogenesis IMP
IMP: 通过突变表型推断
15459098 MGI
involved in pharyngeal system development IMP
IMP: 通过突变表型推断
15459098 MGI
acts upstream of negative effect pigment metabolic process involved in pigmentation IMP
IMP: 通过突变表型推断
26971330 MGI
involved in positive regulation of cardiac muscle cell proliferation IMP
IMP: 通过突变表型推断
15042700 MGI
involved in positive regulation of cell cycle G1/S phase transition IMP
IMP: 通过突变表型推断
26486273 MGI
involved in positive regulation of transcription by RNA polymerase II IDA
IDA: 通过直接分析推断
22186728 MGI
involved in positive regulation of transcription by RNA polymerase II IMP
IMP: 通过突变表型推断
11867218 MGI
involved in regulation of transcription by RNA polymerase II IDA
IDA: 通过直接分析推断
15459098 MGI
involved in response to retinoic acid IDA
IDA: 通过直接分析推断
22186728 MGI
acts upstream of or within roof of mouth development IGI
IGI: 通过遗传相互作用推断
19769959 MGI
acts upstream of or within roof of mouth development IMP
IMP: 通过突变表型推断
19769959 MGI
acts upstream of or within smooth muscle cell differentiation IGI
IGI: 通过遗传相互作用推断
30478225 MGI
acts upstream of or within ureteric peristalsis IGI
IGI: 通过遗传相互作用推断
30478225 MGI
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in cytoplasm IDA
IDA: 通过直接分析推断
18025091 MGI
located in nucleus IDA
IDA: 通过直接分析推断
15042700 MGI
part of transcription regulator complex IDA
IDA: 通过直接分析推断
12023302 MGI
part of transcription regulator complex IPI
IPI: 通过物理相互作用推断
18285513 MGI
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断
蛋白主名 其他名称

T-box transcription factor TBX2

T-box protein 2

相关产品

Pre-clinical Phase
生物活性分子 (3)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS14275 TBX2 Human Pre-designed siRNA Set A Pre-designed Set / 否
HY-RS22339 Tbx2 Mouse Pre-designed siRNA Set A Pre-designed Set / 否
HY-RS28861 Tbx2 Rat Pre-designed siRNA Set A Pre-designed Set / 否

直系同源

种属 基因名 来源 基因 ID
Homo sapiens Tbx2 NCBI NCBI:6909
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