1. Gene
  2. Tbx5 - T-box 5 Gene

Tbx5 - T-box 5 Gene

种属: Mus musculus

基因 ID: 21388 | 基因类型: protein coding

关于 Tbx5

功能概要

Enables DNA-binding transcription activator activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Involved in heart development; positive regulation of gap junction assembly; and positive regulation of transcription by RNA polymerase II. Acts upstream of or within several processes, including cell communication involved in cardiac conduction; heart development; and positive regulation of cell population proliferation. Located in nucleus. Part of transcription regulator complex. Is expressed in several structures, including embryo mesenchyme; eye; genitourinary system; heart; and vena cava. Used to study Holt-Oram syndrome. Human ortholog(s) of this gene implicated in Holt-Oram syndrome. Orthologous to human TBX5 (T-box transcription factor 5). [provided by Alliance of Genome Resources, Apr 2022]

Tbx5 基因产物(1)

mRNA Protein Name
NM_011537.3 NP_035667.1 T-box transcription factor TBX5
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
生物过程 GO 注释 逻辑证据 参考文献 来源
acts upstream of or within atrial septum development IMP
IMP: 通过突变表型推断
19084512 MGI
acts upstream of or within atrial septum morphogenesis IGI
IGI: 通过遗传相互作用推断
22898775 MGI
involved in atrioventricular bundle cell differentiation IMP
IMP: 通过突变表型推断
15289437 MGI
involved in atrioventricular node cell development IMP
IMP: 通过突变表型推断
15289437 MGI
involved in atrioventricular node cell fate commitment IMP
IMP: 通过突变表型推断
15289437 MGI
acts upstream of or within atrioventricular valve morphogenesis IGI
IGI: 通过遗传相互作用推断
19084512 MGI
acts upstream of positive effect bundle of His cell to Purkinje myocyte communication by electrical coupling IMP
IMP: 通过突变表型推断
22728936 MGI
acts upstream of or within bundle of His development IGI
IGI: 通过遗传相互作用推断
17604724 MGI
involved in bundle of His development IMP
IMP: 通过突变表型推断
22728936 MGI
involved in cardiac left ventricle formation IMP
IMP: 通过突变表型推断
19727199 MGI
acts upstream of or within cardiac muscle cell differentiation IGI
IGI: 通过遗传相互作用推断
20691899 MGI
involved in cardiac muscle cell differentiation IMP
IMP: 通过突变表型推断
11431700 MGI
acts upstream of cardiac muscle cell proliferation IGI
IGI: 通过遗传相互作用推断
19084512 MGI
acts upstream of positive effect cell-cell signaling IGI
IGI: 通过遗传相互作用推断
22728936 MGI
acts upstream of or within embryonic forelimb morphogenesis IMP
IMP: 通过突变表型推断
11572777 MGI
acts upstream of or within embryonic limb morphogenesis IGI
IGI: 通过遗传相互作用推断
16380715 MGI
acts upstream of or within embryonic limb morphogenesis IMP
IMP: 通过突变表型推断
12736217 MGI
acts upstream of or within endocardial cushion development IGI
IGI: 通过遗传相互作用推断
19084512 MGI
acts upstream of or within forelimb morphogenesis IMP
IMP: 通过突变表型推断
15621531 MGI
acts upstream of or within heart development IMP
IMP: 通过突变表型推断
11572777 MGI
acts upstream of or within lung development IMP
IMP: 通过突变表型推断
12508227 MGI
acts upstream of or within morphogenesis of an epithelium IMP
IMP: 通过突变表型推断
12508227 MGI
acts upstream of or within pattern specification process IMP
IMP: 通过突变表型推断
15289437 MGI
acts upstream of or within positive regulation of DNA-templated transcription IDA
IDA: 通过直接分析推断
11555635 MGI
acts upstream of positive regulation of cardiac conduction IMP
IMP: 通过突变表型推断
22728936 MGI
acts upstream of or within positive regulation of cardiac muscle cell proliferation IGI
IGI: 通过遗传相互作用推断
19084512 MGI
involved in positive regulation of gap junction assembly IMP
IMP: 通过突变表型推断
22728936 MGI
acts upstream of or within positive regulation of secondary heart field cardioblast proliferation IMP
IMP: 通过突变表型推断
22898775 MGI
involved in positive regulation of transcription by RNA polymerase II IDA
IDA: 通过直接分析推断
22728936 MGI
acts upstream of or within positive regulation of transcription by RNA polymerase II IGI
IGI: 通过遗传相互作用推断
16380715 MGI
acts upstream of or within positive regulation of transcription by RNA polymerase II IMP
IMP: 通过突变表型推断
24565863 MGI
acts upstream of or within regulation of DNA-templated transcription IMP
IMP: 通过突变表型推断
16870172 MGI
acts upstream of positive effect regulation of atrial cardiac muscle cell membrane depolarization IGI
IGI: 通过遗传相互作用推断
22728936 MGI
involved in sinoatrial node development IMP
IMP: 通过突变表型推断
11572777 MGI
acts upstream of transcription by RNA polymerase II IGI
IGI: 通过遗传相互作用推断
17604724 MGI
acts upstream of or within ventricular cardiac muscle tissue development IGI
IGI: 通过遗传相互作用推断
19084512 MGI
involved in ventricular septum development IMP
IMP: 通过突变表型推断
19727199 MGI
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in nucleus IDA
IDA: 通过直接分析推断
11572777 MGI
part of transcription regulator complex IPI
IPI: 通过物理相互作用推断
18285513 MGI
EXP:通过实验结果推断 IDA:通过直接分析推断 IPI:通过物理相互作用推断 IMP:通过突变表型推断 IGI:通过遗传相互作用推断 IEP:通过表达模式推断
蛋白主名 其他名称

T-box transcription factor TBX5

T-box protein 5

直系同源

种属 基因名 来源 基因 ID
Homo sapiens Tbx5 NCBI NCBI:6910