Tfap2a - transcription factor AP-2, alpha Gene

种属: Mus musculus

同用名: Ap2; AP-2; Ap2tf; Tcfap2a; AP2alpha; Ap-2 (a)

基因 ID: 21418 | 基因类型: protein coding

关于 Tfap2a

功能概要

This gene is a member of the activator protein 2 (AP-2) transcription factor family. The protein encoded by this gene can act as both an activator and repressor of gene transcription, and plays an important role in early embryogenesis, specifically in cranial development. This protein forms both homodimers and heterodimers, and binds to a GC-rich consensus sequence found in some promoters and enhancers. Disruption of this gene causes perinatal death, with neural tube, craniofacial, and limb mesenchyme defects. Alternative splicing results in multiple transcript variants that encode multiple protein isoforms. [provided by RefSeq, Sep 2014]

Tfap2a 基因产物(3)

mRNA	Protein	Name
NM_001122948.2	NP_001116420.1	transcription factor AP-2-alpha isoform 3
NM_001301674.2	NP_001288603.2	transcription factor AP-2-alpha isoform 1
NM_011547.5	NP_035677.3	transcription factor AP-2-alpha isoform 1

基因本体论

分子功能
生物过程
细胞组分

分子功能 GO 注释	逻辑证据	参考文献	来源
enables DNA-binding transcription activator activity, RNA polymerase II-specific	IDA IDA: 通过直接分析推断	7555706	MGI
enables DNA-binding transcription factor activity	IDA IDA: 通过直接分析推断	11522791	MGI
enables DNA-binding transcription repressor activity, RNA polymerase II-specific	IDA IDA: 通过直接分析推断	16449191	MGI
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	IDA IDA: 通过直接分析推断	10068641	MGI
enables RNA polymerase II transcription regulatory region sequence-specific DNA binding	IDA IDA: 通过直接分析推断	9858544	MGI
enables chromatin binding	IDA IDA: 通过直接分析推断	15475956	MGI
enables cis-regulatory region sequence-specific DNA binding	IDA IDA: 通过直接分析推断	19943855	MGI
enables protein binding	IPI IPI: 通过物理相互作用推断	11522791	MGI
enables transcription coactivator activity	IDA IDA: 通过直接分析推断	21829553	MGI
enables transcription corepressor activity	IDA IDA: 通过直接分析推断	21829553	MGI

生物过程 GO 注释	逻辑证据	参考文献	来源
acts upstream of or within anterior neuropore closure	IMP IMP: 通过突变表型推断	8622765	MGI
acts upstream of or within basement membrane organization	IMP IMP: 通过突变表型推断	16186342	MGI
involved in bone morphogenesis	IMP IMP: 通过突变表型推断	8622766	MGI
acts upstream of cell population proliferation	IMP IMP: 通过突变表型推断	16449191	MGI
acts upstream of or within cornea development in camera-type eye	IMP IMP: 通过突变表型推断	16186342	MGI
acts upstream of or within embryonic body morphogenesis	IMP IMP: 通过突变表型推断	15013802	MGI
acts upstream of or within embryonic camera-type eye morphogenesis	IMP IMP: 通过突变表型推断	9811866	MGI
acts upstream of or within embryonic cranial skeleton morphogenesis	IMP IMP: 通过突变表型推断	8622765	MGI
involved in embryonic cranial skeleton morphogenesis	IMP IMP: 通过突变表型推断	8622766	MGI
involved in embryonic forelimb morphogenesis	IMP IMP: 通过突变表型推断	9811866	MGI
acts upstream of or within embryonic pattern specification	IMP IMP: 通过突变表型推断	17984226	MGI
acts upstream of epidermal growth factor receptor signaling pathway	IMP IMP: 通过突变表型推断	16449191	MGI
acts upstream of or within epidermis morphogenesis	IMP IMP: 通过突变表型推断	16449191	MGI
involved in eyelid development in camera-type eye	IMP IMP: 通过突变表型推断	9811866	MGI
acts upstream of or within face morphogenesis	IMP IMP: 通过突变表型推断	9811866	MGI
acts upstream of fibroblast migration	IMP IMP: 通过突变表型推断	19463168	MGI
acts upstream of or within forebrain neuron development	IMP IMP: 通过突变表型推断	10803593	MGI
acts upstream of or within forelimb morphogenesis	IMP IMP: 通过突变表型推断	9811866	MGI
acts upstream of or within keratinocyte development	IGI IGI: 通过遗传相互作用推断	18824566	MGI
acts upstream of or within lens induction in camera-type eye	IMP IMP: 通过突变表型推断	10571739	MGI
acts upstream of or within lens morphogenesis in camera-type eye	IMP IMP: 通过突变表型推断	9918694	MGI
involved in metanephric nephron development	IEP IEP: 通过表达模式推断	7555706	MGI
acts upstream of or within negative regulation of cell population proliferation	IMP IMP: 通过突变表型推断	16449191	MGI
acts upstream of or within negative regulation of epidermal growth factor receptor signaling pathway	IMP IMP: 通过突变表型推断	16449191	MGI
acts upstream of or within negative regulation of neuron apoptotic process	IGI IGI: 通过遗传相互作用推断	21539825	MGI
involved in negative regulation of transcription by RNA polymerase II	IDA IDA: 通过直接分析推断	21829553	MGI
involved in nervous system development	IEP IEP: 通过表达模式推断	7555706	MGI
acts upstream of or within neural crest cell development	IMP IMP: 通过突变表型推断	8622766	MGI
acts upstream of or within neural tube closure	IMP IMP: 通过突变表型推断	8622766	MGI
acts upstream of neuron apoptotic process	IGI IGI: 通过遗传相互作用推断	21539825	MGI
involved in oculomotor nerve formation	IMP IMP: 通过突变表型推断	8622766	MGI
involved in optic cup structural organization	IMP IMP: 通过突变表型推断	20150232	MGI
involved in optic vesicle morphogenesis	IMP IMP: 通过突变表型推断	20150232	MGI
acts upstream of or within outflow tract morphogenesis	IMP IMP: 通过突变表型推断	11744375	MGI
involved in positive regulation of DNA-templated transcription	IDA IDA: 通过直接分析推断	15475956	MGI
acts upstream of or within positive regulation of fibroblast migration	IMP IMP: 通过突变表型推断	19463168	MGI
involved in positive regulation of gene expression	IDA IDA: 通过直接分析推断	15475956	MGI
acts upstream of or within positive regulation of transcription by RNA polymerase II	IDA IDA: 通过直接分析推断	7555706	MGI
involved in positive regulation of transcription by RNA polymerase II	IDA IDA: 通过直接分析推断	9858544	MGI
acts upstream of or within regulation of DNA-templated transcription	IDA IDA: 通过直接分析推断	11522791	MGI
acts upstream of or within regulation of neuron differentiation	IMP IMP: 通过突变表型推断	10842061	MGI
acts upstream of or within regulation of transcription by RNA polymerase II	IDA IDA: 通过直接分析推断	15475956	MGI
involved in sensory organ development	IEP IEP: 通过表达模式推断	7555706	MGI
acts upstream of or within skeletal system morphogenesis	IMP IMP: 通过突变表型推断	8622765	MGI
involved in skin development	IEP IEP: 通过表达模式推断	7555706	MGI
acts upstream of or within skin development	IGI IGI: 通过遗传相互作用推断	18824566	MGI
acts upstream of or within sympathetic nervous system development	IGI IGI: 通过遗传相互作用推断	21539825	MGI
acts upstream of transcription by RNA polymerase II	IDA IDA: 通过直接分析推断	11694877	MGI
involved in trigeminal nerve development	IMP IMP: 通过突变表型推断	8622766	MGI

细胞组分 GO 注释	逻辑证据	参考文献	来源
located in clathrin-coated pit	IDA IDA: 通过直接分析推断	26437238	MGI
located in nucleus	IDA IDA: 通过直接分析推断	10842061	MGI

EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

蛋白主名

其他名称

transcription factor AP-2-alpha

activating enhancer-binding protein 2 alpha

activator protein 2

Cat. No.	产品名	作用方式	纯度	是否罕见病
HY-RS14408	TFAP2A Human Pre-designed siRNA Set A	Pre-designed Set	/	否
HY-RS19271	Tfap2a Mouse Pre-designed siRNA Set A	Pre-designed Set	/	否
HY-RS25760	Tfap2a Rat Pre-designed siRNA Set A	Pre-designed Set	/	否

直系同源

种属	基因名	来源	基因 ID
Homo sapiens	Tfap2a	NCBI	NCBI:7020

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MedChemExpress (MCE) 只为有资质的科研机构、医药企业基于科学研究或药证申报的用途提供医药研发服务，不为任何个人或者非科研性质的、非用于药证申报使用等其他用途提供服务。

站点地图隐私声明

沪ICP备15051369号-4

上海工商

沪公网安备31011502019417

沪(浦)应急管危经许[2021]201709(QFYS)

营业执照（三证合一）

Tfap2a - transcription factor AP-2, alpha Gene

关于 Tfap2a

功能概要

Tfap2a 基因产物(3)

直系同源

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Tfap2a - transcription factor AP-2, alpha Gene

关于 Tfap2a

功能概要

Tfap2a 基因产物(3)

相关产品

直系同源

热门区域

A

B

C

F

G

H

J

L

N

Q

S

T

X

Y

Z