2. Gene
  3. Tdgf1 - teratocarcinoma-derived growth factor 1 Gene

Tdgf1 - teratocarcinoma-derived growth factor 1 Gene

  • 基因
  • 蛋白
  • 相关产品
  • 直系同源

种属: Mus musculus

同用名: CR1; cripto

基因 ID: 21667 | 基因类型: protein coding

关于 Tdgf1

功能概要

Enables several functions, including Wnt-protein binding activity; nodal binding activity; and type I activin receptor binding activity. Involved in several processes, including morphogenesis of a branching structure; nodal signaling pathway; and positive regulation of cell migration. Acts upstream of or within several processes, including circulatory system development; negative regulation of transforming growth factor beta receptor signaling pathway; and positive regulation of fibroblast proliferation. Located in several cellular components, including Golgi apparatus; cell surface; and perinuclear region of cytoplasm. Is extrinsic component of plasma membrane. Is expressed in several structures, including blastocyst; brain; embryo mesoderm; extraembryonic component; and heart. Human ortholog(s) of this gene implicated in colon Cancer and congenital heart disease. Orthologous to several human genes including TDGF1 (teratocarcinoma-derived growth factor 1). [provided by Alliance of Genome Resources, Apr 2022]

Tdgf1 基因产物(2)

mRNA Protein Name
NM_011562.2 NP_035692.2 teratocarcinoma-derived growth factor precursor
NM_011562.2 NP_035692.2 teratocarcinoma-derived growth factor precursor
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables Wnt-protein binding IPI
IPI: 通过物理相互作用推断
15797385 MGI
enables coreceptor activity IDA
IDA: 通过直接分析推断
11389842 MGI
enables nodal binding IPI
IPI: 通过物理相互作用推断
12052855 MGI
enables protein binding IPI
IPI: 通过物理相互作用推断
14966532 MGI
enables type I activin receptor binding IPI
IPI: 通过物理相互作用推断
11389842 MGI
生物过程 GO 注释 逻辑证据 参考文献 来源
acts upstream of or within anterior/posterior axis specification IGI
IGI: 通过遗传相互作用推断
18241853 MGI
acts upstream of or within anterior/posterior axis specification, embryo IMP
IMP: 通过突变表型推断
9790191 MGI
acts upstream of or within cardiac muscle cell differentiation IMP
IMP: 通过突变表型推断
9876177 MGI
acts upstream of fibroblast proliferation IMP
IMP: 通过突变表型推断
9876177 MGI
acts upstream of or within gastrulation IGI
IGI: 通过遗传相互作用推断
18241853 MGI
involved in heart development IDA
IDA: 通过直接分析推断
9576836 MGI
acts upstream of or within in utero embryonic development IMP
IMP: 通过突变表型推断
9876177 MGI
involved in morphogenesis of a branching structure IDA
IDA: 通过直接分析推断
11133982 MGI
acts upstream of or within negative regulation of transforming growth factor beta receptor signaling pathway IGI
IGI: 通过遗传相互作用推断
17991893 MGI
involved in nodal signaling pathway IGI
IGI: 通过遗传相互作用推断
11389842 MGI
involved in nodal signaling pathway IMP
IMP: 通过突变表型推断
12052855 MGI
involved in positive regulation of cell migration IDA
IDA: 通过直接分析推断
11133982 MGI
acts upstream of or within positive regulation of cell-matrix adhesion IMP
IMP: 通过突变表型推断
9876177 MGI
acts upstream of or within positive regulation of fibroblast proliferation IMP
IMP: 通过突变表型推断
9876177 MGI
acts upstream of or within positive regulation of transcription by RNA polymerase II IGI
IGI: 通过遗传相互作用推断
17568773 MGI
acts upstream of or within regulation of fibroblast migration IMP
IMP: 通过突变表型推断
9876177 MGI
acts upstream of or within regulation of signal transduction IDA
IDA: 通过直接分析推断
17936261 MGI
acts upstream of or within vasculogenesis IMP
IMP: 通过突变表型推断
9876177 MGI
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in Golgi apparatus IDA
IDA: 通过直接分析推断
8588926 MGI
located in cell surface IDA
IDA: 通过直接分析推断
17991893 MGI
located in cytoplasm IDA
IDA: 通过直接分析推断
8588926 MGI
located in extracellular region IDA
IDA: 通过直接分析推断
12052855 MGI
located in extracellular space IDA
IDA: 通过直接分析推断
10640699 MGI
located in nucleus IDA
IDA: 通过直接分析推断
8588926 MGI
located in perinuclear region of cytoplasm IDA
IDA: 通过直接分析推断
8588926 MGI
located in plasma membrane IDA
IDA: 通过直接分析推断
10640699 MGI
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断
蛋白主名 其他名称

teratocarcinoma-derived growth factor

TERATOCARCINOMA-DERIVED GROWTH FACTOR PRECURSOR (EPIDERMAL GROWTH FACTOR-LIKE CRIPTO PROTEIN) (CRIPTO GROWTH FACTOR)

cripto growth factor

epidermal growth factor-like Cripto protein

相关产品

Pre-clinical Phase
生物活性分子 (2)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS14330 TDGF1 Human Pre-designed siRNA Set A Pre-designed Set / 否
HY-RS16445 TDGF1P3 Human Pre-designed siRNA Set A Pre-designed Set / 否
抗体抑制剂 (1)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-P991640 Anti-TDGF1 antibody (huB3F6) / 否

直系同源

种属 基因名 来源 基因 ID
Homo sapiens Tdgf1 NCBI NCBI:6997
Rattus norvegicus Tdgf1 NCBI NCBI:680246
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