2. Gene
  3. Tnfaip3 - tumor necrosis factor, alpha-induced protein 3 Gene

Tnfaip3 - tumor necrosis factor, alpha-induced protein 3 Gene

  • 基因
  • 蛋白
  • 相关产品
  • 直系同源

种属: Mus musculus

同用名: A20; Tnfip3

基因 ID: 21929 | 基因类型: protein coding

关于 Tnfaip3

功能概要

Enables kinase binding activity and protein C-terminus binding activity. Involved in several processes, including negative regulation of cytokine production; negative regulation of defense response; and negative regulation of signal transduction. Acts upstream of or within establishment of protein localization to vacuole; positive regulation of cellular protein catabolic process; and protein K63-linked deubiquitination. Located in cytoplasm. Is expressed in central nervous system; genitourinary system; heart; and retina nuclear layer. Human ortholog(s) of this gene implicated in familial Behcet-like autoinflammatory syndrome. Orthologous to human TNFAIP3 (TNF alpha induced protein 3). [provided by Alliance of Genome Resources, Apr 2022]

Tnfaip3 基因产物(2)

mRNA Protein Name
NM_001166402.1 NP_001159874.1 tumor necrosis factor alpha-induced protein 3 isoform 2
NM_009397.3 NP_033423.3 tumor necrosis factor alpha-induced protein 3 isoform 1
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables kinase binding IDA
IDA: 通过直接分析推断
18342009 MGI
enables protein binding IDA
IDA: 通过直接分析推断
22733818 MGI
enables protein binding IPI
IPI: 通过物理相互作用推断
10385526 MGI
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in B-1 B cell homeostasis IMP
IMP: 通过突变表型推断
21088135 MGI
involved in cellular response to hydrogen peroxide IMP
IMP: 通过突变表型推断
23609450 MGI
acts upstream of or within establishment of protein localization to vacuole IDA
IDA: 通过直接分析推断
18952128 MGI
involved in negative regulation of B cell activation IDA
IDA: 通过直接分析推断
21088135 MGI
involved in negative regulation of canonical NF-kappaB signal transduction IMP
IMP: 通过突变表型推断
18342009 MGI
involved in negative regulation of chronic inflammatory response IMP
IMP: 通过突变表型推断
18006655 MGI
involved in negative regulation of cyclin-dependent protein serine/threonine kinase activity IDA
IDA: 通过直接分析推断
15962316 MGI
involved in negative regulation of extrinsic apoptotic signaling pathway IMP
IMP: 通过突变表型推断
11009421 MGI
involved in negative regulation of inflammatory response IDA
IDA: 通过直接分析推断
23609450 MGI
involved in negative regulation of inflammatory response IMP
IMP: 通过突变表型推断
21088135 MGI
involved in negative regulation of innate immune response IMP
IMP: 通过突变表型推断
23609450 MGI
involved in negative regulation of interleukin-1 beta production IMP
IMP: 通过突变表型推断
18006655 MGI
involved in negative regulation of interleukin-6 production IMP
IMP: 通过突变表型推断
18006655 MGI
involved in negative regulation of nucleotide-binding oligomerization domain containing 1 signaling pathway IMP
IMP: 通过突变表型推断
18342009 MGI
involved in negative regulation of nucleotide-binding oligomerization domain containing 2 signaling pathway IDA
IDA: 通过直接分析推断
18342009 MGI
involved in negative regulation of toll-like receptor 5 signaling pathway IDA
IDA: 通过直接分析推断
19912257 MGI
involved in negative regulation of tumor necrosis factor production IMP
IMP: 通过突变表型推断
21088135 MGI
involved in positive regulation of hepatocyte proliferation IDA
IDA: 通过直接分析推断
15962316 MGI
acts upstream of or within positive regulation of protein catabolic process IDA
IDA: 通过直接分析推断
18952128 MGI
acts upstream of or within protein K63-linked deubiquitination IDA
IDA: 通过直接分析推断
24012418 MGI
involved in protein deubiquitination IDA
IDA: 通过直接分析推断
18342009 MGI
involved in regulation of germinal center formation IMP
IMP: 通过突变表型推断
21088135 MGI
involved in response to molecule of bacterial origin IDA
IDA: 通过直接分析推断
19912257 MGI
involved in response to muramyl dipeptide IMP
IMP: 通过突变表型推断
18342009 MGI
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in cytoplasm IDA
IDA: 通过直接分析推断
10385526 MGI
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断
蛋白主名 其他名称

tumor necrosis factor alpha-induced protein 3

TNF alpha-induced protein 3

putative DNA-binding protein A20

tumor necrosis factor induced protein 3

zinc finger protein A20

相关产品

Pre-clinical Phase
生物活性分子 (4)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS14789 TNFAIP3 Human Pre-designed siRNA Set A Pre-designed Set / 否
HY-170863 ZSH-2208 Agonist 99.90% 否
HY-RS17044 Tnfaip3 Mouse Pre-designed siRNA Set A Pre-designed Set / 否
HY-RS23488 Tnfaip3 Rat Pre-designed siRNA Set A Pre-designed Set / 否

直系同源

种属 基因名 来源 基因 ID
Homo sapiens Tnfaip3 NCBI NCBI:7128
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