Tnfrsf11a - tumor necrosis factor receptor superfamily, member 11a, NFKB activator Gene

中文名称：肿瘤坏死因子受体超家族，成员 11 a，NFKB 激活因子

种属: Mus musculus

同用名: OFE; ODFR; Rank; Ly109; mRANK; TRANCE-R

关于 Tnfrsf11a

功能概要

该基因编码的蛋白可启动肿瘤坏死因子激活受体活性。涉及多个过程，包括昼夜节律温度稳态；通过正向调节前列腺素分泌来正向调节发热的产生；和肿瘤坏死因子介导的信号通路。作用于几个过程的上游或内部，包括造血或淋巴器官发育；乳腺肺泡发育；骨吸收的正调节作用。位于细胞表面。在膀胱和淋巴系统中表达。该基因的人类直系同源物与佩吉特骨病有关；常染色体隐性骨硬化症 7；骨发育疾病；家族性膨胀性骨质溶解；和骨质疏松症。与人类 TNFRSF11A（TNF 受体超家族成员 11a）同源。 [由基因组资源联盟提供，2022 年 4 月]

Enables tumor necrosis factor-activated receptor activity. Involved in several processes, including circadian temperature homeostasis; positive regulation of fever generation by positive regulation of prostaglandin secretion; and tumor necrosis factor-mediated signaling pathway. Acts upstream of or within several processes, including hematopoietic or lymphoid organ development; mammary gland alveolus development; and positive regulation of bone resorption. Located in cell surface. Is expressed in bladder and lymphatic system. Human ortholog(s) of this gene implicated in Paget's disease of bone; autosomal recessive osteopetrosis 7; bone development disease; familial expansile osteolysis; and osteoporosis. Orthologous to human TNFRSF11A (TNF Receptor Superfamily member 11a). [provided by Alliance of Genome Resources, Apr 2022]