2. Gene
  3. Tpm1 - tropomyosin 1, alpha Gene

Tpm1 - tropomyosin 1, alpha Gene

  • 基因
  • 蛋白
  • 相关产品
  • 直系同源

种属: Mus musculus

同用名: TM2; Tm3; Tmpa; Tpm-1; alpha-TM; TPM1kappa

基因 ID: 22003 | 基因类型: protein coding

关于 Tpm1

功能概要

Enables actin filament binding activity. Involved in cardiac muscle contraction; positive regulation of heart rate by epinephrine; and ventricular cardiac muscle tissue morphogenesis. Acts upstream of or within in utero embryonic development. Located in myofibril. Is expressed in several structures, including central nervous system; gut; heart; limb segment; and musculature. Used to study dilated cardiomyopathy 1Y and hypertrophic cardiomyopathy 3. Human ortholog(s) of this gene implicated in dilated cardiomyopathy 1Y; familial hypertrophic cardiomyopathy; and hypertrophic cardiomyopathy 3. Orthologous to human TPM1 (tropomyosin 1). [provided by Alliance of Genome Resources, Apr 2022]

Tpm1 基因产物(10)

mRNA Protein Name
NM_001164248.1 NP_001157720.1 tropomyosin alpha-1 chain isoform Tpm1.1st
NM_001164249.1 NP_001157721.1 tropomyosin alpha-1 chain isoform Tpm1.2st
NM_001164250.1 NP_001157722.1 tropomyosin alpha-1 chain isoform Tpm1.7cy
NM_001164251.1 NP_001157723.1 tropomyosin alpha-1 chain isoform Tpm1.5cy
NM_001164252.1 NP_001157724.1 tropomyosin alpha-1 chain isoform Tpm1.8cy
NM_001164253.1 NP_001157725.1 tropomyosin alpha-1 chain isoform Tpm1.9cy
NM_001164254.1 NP_001157726.1 tropomyosin alpha-1 chain isoform Tpm1.13
NM_001164255.1 NP_001157727.1 tropomyosin alpha-1 chain isoform Tpm1.10br
NM_001164256.1 NP_001157728.1 tropomyosin alpha-1 chain isoform Tpm1.12br
NM_024427.4 NP_077745.2 tropomyosin alpha-1 chain isoform Tpm1.6cy
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables actin filament binding IDA
IDA: 通过直接分析推断
16765662 MGI
enables protein binding IPI
IPI: 通过物理相互作用推断
25470062 MGI
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in cardiac muscle contraction IMP
IMP: 通过突变表型推断
17556658 MGI
acts upstream of or within embryo development IMP
IMP: 通过突变表型推断
9400381 MGI
acts upstream of or within in utero embryonic development IMP
IMP: 通过突变表型推断
9440710 MGI
involved in positive regulation of heart rate by epinephrine IMP
IMP: 通过突变表型推断
17556658 MGI
involved in ventricular cardiac muscle tissue morphogenesis IMP
IMP: 通过突变表型推断
17556658 MGI
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in cytoplasm IDA
IDA: 通过直接分析推断
16765662 MGI
located in myofibril IDA
IDA: 通过直接分析推断
9440710 MGI
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断
蛋白主名 其他名称

tropomyosin alpha-1 chain

alpha-tropomyosin

tropomyosin 1 kappa

tropomyosin-1

相关产品

Pre-clinical Phase
生物活性分子 (3)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS14936 TPM1 Human Pre-designed siRNA Set A Pre-designed Set / 否
HY-RS17596 Tpm1 Mouse Pre-designed siRNA Set A Pre-designed Set / 否
HY-RS24056 Tpm1 Rat Pre-designed siRNA Set A Pre-designed Set / 否

直系同源

种属 基因名 来源 基因 ID
Homo sapiens Tpm1 NCBI NCBI:7168
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