Trex1 - three prime repair exonuclease 1 Gene

种属: Mus musculus

基因 ID: 22040 | 基因类型: protein coding

关于 Trex1

功能概要

Enables several functions, including DNA binding activity; WW domain binding activity; and magnesium ion binding activity. Involved in DNA metabolic process. Acts upstream of or within several processes, including DNA metabolic process; cellular response to cytokine stimulus; and regulation of generation of precursor metabolites and energy. Located in cytosol; endoplasmic reticulum; and nuclear replication fork. Part of oligosaccharyltransferase complex and protein-DNA complex. Used to study Aicardi-Goutieres syndrome and cutaneous lupus erythematosus. Human ortholog(s) of this gene implicated in Aicardi-Goutieres syndrome; Chilblain lupus; retinal vasculopathy with cerebral leukodystrophy; and systemic lupus erythematosus. Orthologous to human TREX1 (three prime repair exonuclease 1). [provided by Alliance of Genome Resources, Apr 2022]

Trex1 基因产物(2)

mRNA	Protein	Name
NM_001012236.1	NP_001012236.1	three-prime repair exonuclease 1
NM_011637.6	NP_035767.4	three-prime repair exonuclease 1

基因本体论

分子功能
生物过程
细胞组分

分子功能 GO 注释	逻辑证据	参考文献	来源
enables 3'-5' exonuclease activity	IMP IMP: 通过突变表型推断	15254239	MGI
enables 3'-5'-DNA exonuclease activity	IDA IDA: 通过直接分析推断	11279105	MGI
enables DNA binding	IDA IDA: 通过直接分析推断	20871604	MGI
enables DNA binding, bending	IDA IDA: 通过直接分析推断	25848017	MGI
enables WW domain binding	IDA IDA: 通过直接分析推断	17355961	MGI
enables adenyl deoxyribonucleotide binding	IDA IDA: 通过直接分析推断	17293595	MGI
enables double-stranded DNA binding	IDA IDA: 通过直接分析推断	19158679	MGI
enables identical protein binding	IPI IPI: 通过物理相互作用推断	17293595	MGI
enables magnesium ion binding	IDA IDA: 通过直接分析推断	25848017	MGI
enables protein binding	IPI IPI: 通过物理相互作用推断	11279105	MGI
enables protein homodimerization activity	IPI IPI: 通过物理相互作用推断	11279105	MGI
enables single-stranded DNA binding	IDA IDA: 通过直接分析推断	17293595	MGI

生物过程 GO 注释	逻辑证据	参考文献	来源
acts upstream of or within CD86 biosynthetic process	IMP IMP: 通过突变表型推断	24218451	MGI
acts upstream of or within DNA catabolic process	IDA IDA: 通过直接分析推断	20871604	MGI
acts upstream of or within DNA catabolic process	IMP IMP: 通过突变表型推断	18724932	MGI
acts upstream of or within DNA damage checkpoint signaling	IMP IMP: 通过突变表型推断	18045533	MGI
acts upstream of or within DNA damage response	IDA IDA: 通过直接分析推断	20511593	MGI
acts upstream of or within DNA duplex unwinding	IDA IDA: 通过直接分析推断	25848017	MGI
involved in DNA metabolic process	IDA IDA: 通过直接分析推断	11279105	MGI
acts upstream of or within DNA modification	IMP IMP: 通过突变表型推断	24205360	MGI
acts upstream of or within DNA replication	IMP IMP: 通过突变表型推断	20511593	MGI
acts upstream of or within DNA synthesis involved in UV-damage excision repair	IMP IMP: 通过突变表型推断	23993650	MGI
acts upstream of or within G2 phase	IMP IMP: 通过突变表型推断	18045533	MGI
acts upstream of or within T cell antigen processing and presentation	IMP IMP: 通过突变表型推断	24218451	MGI
acts upstream of or within activation of immune response	IMP IMP: 通过突变表型推断	18045533	MGI
acts upstream of or within adaptive immune response	IMP IMP: 通过突变表型推断	25848017	MGI
acts upstream of or within apoptotic cell clearance	IMP IMP: 通过突变表型推断	24218451	MGI
acts upstream of or within atrial cardiac muscle tissue development	IMP IMP: 通过突变表型推断	15254239	MGI
acts upstream of or within blood vessel development	IMP IMP: 通过突变表型推断	25848017	MGI
acts upstream of or within cellular response to UV	IDA IDA: 通过直接分析推断	20511593	MGI
acts upstream of or within cellular response to gamma radiation	IMP IMP: 通过突变表型推断	18045533	MGI
acts upstream of or within cellular response to hydroxyurea	IMP IMP: 通过突变表型推断	18045533	MGI
acts upstream of or within cellular response to interferon-beta	IDA IDA: 通过直接分析推断	19158679	MGI
acts upstream of or within cellular response to oxidative stress	IMP IMP: 通过突变表型推断	23993650	MGI
acts upstream of or within cellular response to reactive oxygen species	IMP IMP: 通过突变表型推断	23993650	MGI
acts upstream of or within cellular response to type I interferon	IMP IMP: 通过突变表型推断	28835460	MGI
acts upstream of or within defense response to virus	IMP IMP: 通过突变表型推断	20871604	MGI
acts upstream of or within determination of adult lifespan	IGI IGI: 通过遗传相互作用推断	26371324	MGI
acts upstream of or within determination of adult lifespan	IMP IMP: 通过突变表型推断	15254239	MGI
acts upstream of or within establishment of protein localization	IMP IMP: 通过突变表型推断	23160154	MGI
acts upstream of or within generation of precursor metabolites and energy	IMP IMP: 通过突变表型推断	28069950	MGI
acts upstream of or within heart morphogenesis	IMP IMP: 通过突变表型推断	15254239	MGI
acts upstream of or within heart process	IMP IMP: 通过突变表型推断	15254239	MGI
acts upstream of or within immune complex formation	IMP IMP: 通过突变表型推断	25848017	MGI
acts upstream of or within immune response	IMP IMP: 通过突变表型推断	28835460	MGI
acts upstream of or within immune response in brain or nervous system	IMP IMP: 通过突变表型推断	24218451	MGI
acts upstream of or within immunoglobulin production involved in immunoglobulin-mediated immune response	IMP IMP: 通过突变表型推断	25848017	MGI
acts upstream of or within inflammatory response	IMP IMP: 通过突变表型推断	15254239	MGI
acts upstream of or within inflammatory response to antigenic stimulus	IMP IMP: 通过突变表型推断	24218451	MGI
acts upstream of or within innate immune response	IMP IMP: 通过突变表型推断	23160154	MGI
acts upstream of or within interferon-alpha production	IMP IMP: 通过突变表型推断	24218451	MGI
acts upstream of or within kidney development	IMP IMP: 通过突变表型推断	25848017	MGI
acts upstream of or within lymphoid progenitor cell differentiation	IMP IMP: 通过突变表型推断	25848017	MGI
acts upstream of or within macrophage activation involved in immune response	IMP IMP: 通过突变表型推断	24218451	MGI
acts upstream of or within mitotic G1 DNA damage checkpoint signaling	IMP IMP: 通过突变表型推断	18045533	MGI
acts upstream of or within negative regulation of type I interferon-mediated signaling pathway	IMP IMP: 通过突变表型推断	18724932	MGI
acts upstream of or within organ or tissue specific immune response	IMP IMP: 通过突变表型推断	24218451	MGI
acts upstream of or within protein stabilization	IDA IDA: 通过直接分析推断	26320659	MGI
acts upstream of or within regulation of T cell activation	IGI IGI: 通过遗传相互作用推断	26371324	MGI
acts upstream of or within regulation of catalytic activity	IMP IMP: 通过突变表型推断	23160154	MGI
acts upstream of or within regulation of cellular metabolic process	IGI IGI: 通过遗传相互作用推断	28069950	MGI
acts upstream of or within regulation of cellular metabolic process	IMP IMP: 通过突变表型推断	28069950	MGI
acts upstream of or within regulation of cellular respiration	IMP IMP: 通过突变表型推断	28069950	MGI
acts upstream of or within regulation of fatty acid metabolic process	IMP IMP: 通过突变表型推断	28069950	MGI
acts upstream of or within regulation of gene expression	IGI IGI: 通过遗传相互作用推断	23160154	MGI
acts upstream of or within regulation of gene expression	IMP IMP: 通过突变表型推断	23160154	MGI
acts upstream of or within regulation of glycolytic process	IMP IMP: 通过突变表型推断	28069950	MGI
acts upstream of or within regulation of immunoglobulin production	IGI IGI: 通过遗传相互作用推断	26371324	MGI
acts upstream of or within regulation of immunoglobulin production	IMP IMP: 通过突变表型推断	26320659	MGI
acts upstream of or within regulation of inflammatory response	IGI IGI: 通过遗传相互作用推断	28069950	MGI
acts upstream of or within regulation of innate immune response	IMP IMP: 通过突变表型推断	20871604	MGI
acts upstream of or within regulation of lipid biosynthetic process	IGI IGI: 通过遗传相互作用推断	28069950	MGI
acts upstream of or within regulation of lysosome organization	IMP IMP: 通过突变表型推断	23160154	MGI
acts upstream of or within regulation of protein complex stability	IMP IMP: 通过突变表型推断	26320659	MGI
acts upstream of or within regulation of tumor necrosis factor production	IMP IMP: 通过突变表型推断	24218451	MGI
acts upstream of or within regulation of type I interferon production	IGI IGI: 通过遗传相互作用推断	26371324	MGI
acts upstream of or within regulation of type I interferon production	IMP IMP: 通过突变表型推断	20871604	MGI
acts upstream of or within response to UV	IMP IMP: 通过突变表型推断	28351661	MGI
acts upstream of or within retrotransposition	IMP IMP: 通过突变表型推断	28835460	MGI
acts upstream of or within type I interferon-mediated signaling pathway	IMP IMP: 通过突变表型推断	28351661	MGI

细胞组分 GO 注释	逻辑证据	参考文献	来源
located in cytoplasm	IDA IDA: 通过直接分析推断	17355961	MGI
located in cytosol	IDA IDA: 通过直接分析推断	28351661	MGI
located in endoplasmic reticulum	IDA IDA: 通过直接分析推断	18724932	MGI
located in nuclear replication fork	IDA IDA: 通过直接分析推断	18045533	MGI
located in nucleus	IDA IDA: 通过直接分析推断	18045533	MGI
part of oligosaccharyltransferase complex	IDA IDA: 通过直接分析推断	26320659	MGI
part of protein-DNA complex	IDA IDA: 通过直接分析推断	25848017	MGI

EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

蛋白主名

其他名称

three-prime repair exonuclease 1

3'-5' exonuclease TREX1	DNase III
three prime exonuclease 1	trophoblast expressed 1

Trex1 抗体

目录号	产品名	应用	反应物种
HY-P87119	TREX1 Antibody (YA6812)	WB, FC, IP	Mouse

Cat. No.	产品名	作用方式	纯度	是否罕见病
HY-160785	TREX1-IN-1	Modulator	99.32%	否
HY-173425	STING-IN-15	Inhibitor	/	否
HY-160786	TREX1-IN-3	Inhibitor	/	否
HY-160786A	TREX1-IN-4	Inhibitor	/	否
HY-RS15008	TREX1 Human Pre-designed siRNA Set A	Pre-designed Set	/	否
HY-RS17776	Trex1 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	否
HY-RS24243	Trex1 Rat Pre-designed siRNA Set A	Pre-designed Set	/	否

直系同源

种属	基因名	来源	基因 ID
Homo sapiens	Trex1	NCBI	NCBI:11277

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MedChemExpress (MCE) 只为有资质的科研机构、医药企业基于科学研究或药证申报的用途提供医药研发服务，不为任何个人或者非科研性质的、非用于药证申报使用等其他用途提供服务。

站点地图隐私声明

沪ICP备15051369号-4

上海工商

沪公网安备31011502019417

沪(浦)应急管危经许[2021]201709(QFYS)

营业执照（三证合一）

Trex1 - three prime repair exonuclease 1 Gene

关于 Trex1

功能概要

Trex1 基因产物(2)

Trex1 抗体

直系同源

热门区域

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Trex1 - three prime repair exonuclease 1 Gene

关于 Trex1

功能概要

Trex1 基因产物(2)

Trex1 抗体

相关产品

直系同源

热门区域

A

B

C

F

G

H

J

L

N

Q

S

T

X

Y

Z