2. Gene
  3. TMED4 - transmembrane p24 trafficking protein 4 Gene

TMED4 - transmembrane p24 trafficking protein 4 Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：跨膜 p24 运输蛋白 4

种属: Homo sapiens

同用名: HNLF; ERS25; p24a3; GMP25iso; p24alpha3

基因 ID: 222068 | 基因类型: protein coding

关于 TMED4

Cytogenetic location: 7p13 Genomic coordinates (GRCh38): 7:44,577,894-44,582,231 (from NCBI)

This gene has 5 transcripts (splice variants), 212 orthologues and 8 paralogues. Ubiquitous expression in thyroid (RPKM 37.8), small intestine (RPKM 27.8) and 25 other tissues.

功能概要

参与 I-kappaB 激酶/NF-kappaB 信号的正向调节。预测位于内质网膜。预计是膜的组成部分。预计在几种细胞成分中具有活性，包括 COPII 包被的 ER 到高尔基体转运囊泡；高尔基体;和内质网-高尔基中间室。 [由基因组资源联盟提供，2022 年 4 月]

Involved in positive regulation of I-kappaB kinase/NF-kappaB signaling. Predicted to be located in endoplasmic reticulum membrane. Predicted to be integral component of membrane. Predicted to be active in several cellular components, including COPII-coated ER to Golgi transport vesicle; Golgi apparatus; and endoplasmic reticulum-Golgi intermediate compartment. [provided by Alliance of Genome Resources, Apr 2022]

TMED4 基因产物(6)

mRNA Protein Name
NM_001303058.2 NP_001289987.1 transmembrane emp24 domain-containing protein 4 isoform 2 precursor
NM_001303059.2 NP_001289988.1 transmembrane emp24 domain-containing protein 4 isoform 3 precursor
NM_001303060.2 NP_001289989.1 transmembrane emp24 domain-containing protein 4 isoform 4
NM_001303061.2 NP_001289990.1 transmembrane emp24 domain-containing protein 4 isoform 5
NM_001303062.2 NP_001289991.1 transmembrane emp24 domain-containing protein 4 isoform 5
NM_182547.4 NP_872353.2 transmembrane emp24 domain-containing protein 4 isoform 1 precursor

TMED4 蛋白结构

EMP24_GP25L

EMP24_GP25L: emp24/gp25L/p24 family/GOLD (30 - 222)

  • 0
  • 100
  • 200
  • 227 a.a.
蛋白主名 其他名称

transmembrane emp24 domain-containing protein 4

endoplasmic reticulum stress-response protein 25 kDa

重组 TMED4 蛋白

目录号 产品名 蛋白编号 纯度
HY-P77242 TMED4 Protein, Human (HEK293, His) Q7Z7H5 (L30-R194) ≥95%
HY-P77243 TMED4 Protein, Human (HEK293, Fc) Q7Z7H5 (M1-R194) ≥95%

关联疾病

疾病名称 别名
Ceroid Lipofuscinosis, Neuronal, 8

Neuronal Ceroid Lipofuscinosis 8

CLN8

Cln8 Disease

Epilepsy Mental Deterioration Finnish Type

Northern Epilepsy

Cln8 Disease, Epmr

Cln8 Disease, Northern Epilepsy Variant

Cln8 Disease, Late Infantile

Ceroid Lipofuscinosis Neuronal 8

Ncl, Northern Epilepsy Variant

Neuronal Ceroid Lipofuscinosis, Northern Epilepsy Variant

Progressive Epilepsy - Intellectual Disability, Finnish Type

Progressive Epilepsy-Intellectual Disability Syndrome, Finnish Type

Turkish Variant Late Infantile Ncl

Ceroid Lipofuscinosis, Neuronal 8

Lipofuscinosis, Ceroid, Neuronal, Type 8

Northern Epilepsy Syndrome
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Pre-clinical Phase
生物活性分子 (1)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS14638 TMED4 Human Pre-designed siRNA Set A / 否

直系同源

种属 基因名 来源 基因 ID
Bos taurus TMED4 VGNC VGNC:35937
Macaca mulatta TMED4 VGNC VGNC:79352
Mus musculus TMED4 MGD MGI:1915070
Rattus norvegicus TMED4 RGD RGD:1306319
Canis familiaris TMED4 VGNC VGNC:47439
Felis catus TMED4 VGNC VGNC:66249
Others TMED4 NCBI
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