2. Gene
  3. Ucp2 - uncoupling protein 2 (mitochondrial, proton carrier) Gene

Ucp2 - uncoupling protein 2 (mitochondrial, proton carrier) Gene

  • 基因
  • 蛋白
  • 相关产品
  • 直系同源

种属: Mus musculus

同用名: UCPH; UCP 2; Slc25a8

基因 ID: 22228 | 基因类型: protein coding

关于 Ucp2

功能概要

Predicted to enable Oxidative Phosphorylation uncoupler activity. Involved in positive regulation of cold-induced thermogenesis and regulation of mitochondrial membrane potential. Located in mitochondrion. Is expressed in several structures, including adipose tissue; alimentary system; hemolymphoid system; integumental system; and nose. Used to study polycystic liver disease. Human ortholog(s) of this gene implicated in artery disease (multiple); diabetic neuropathy; end stage renal disease; non-alcoholic fatty liver disease; and obesity. Orthologous to human UCP2 (uncoupling protein 2). [provided by Alliance of Genome Resources, Apr 2022]

Ucp2 基因产物(1)

mRNA Protein Name
NM_011671.5 NP_035801.3 mitochondrial uncoupling protein 2
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables GDP binding IDA
IDA: 通过直接分析推断
25127353 MGI
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in cellular response to glucose stimulus IMP
IMP: 通过突变表型推断
26919426 MGI
involved in long-chain fatty acid transport IDA
IDA: 通过直接分析推断
25127353 MGI
involved in macrophage differentiation IMP
IMP: 通过突变表型推断
34644537 MGI
involved in mitochondrial fission IMP
IMP: 通过突变表型推断
26919426 MGI
acts upstream of or within negative regulation of neuron apoptotic process IMP
IMP: 通过突变表型推断
22956852 MGI
involved in positive regulation of cold-induced thermogenesis IMP
IMP: 通过突变表型推断
28130074 MGI
involved in reactive oxygen species metabolic process IMP
IMP: 通过突变表型推断
26919426 MGI
involved in regulation of mitochondrial membrane potential IMP
IMP: 通过突变表型推断
22736029 MGI
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in mitochondrial membrane IDA
IDA: 通过直接分析推断
34644537 MGI
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断
蛋白主名 其他名称

mitochondrial uncoupling protein 2

solute carrier family 25 member 8

uncoupling protein 2, mitochondrial

相关产品

Clinical Phase
生物活性分子 (2)
目录号 产品名 作用方式
纯度 Phase
HY-17389 Genipin Inhibitor 99.80% Phase 3
HY-138830 TAK-418 Inhibitor 99.81% Phase 1
Pre-clinical Phase
生物活性分子 (6)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-120160 Darglitazone Agonist 99.19% 否
HY-101824 NC-2100 Activator / 否
HY-120160A Darglitazone Sodium Agonist / 否
HY-RS15411 UCP2 Human Pre-designed siRNA Set A Pre-designed Set / 否
HY-RS17900 Ucp2 Mouse Pre-designed siRNA Set A Pre-designed Set / 否
HY-RS24369 Ucp2 Rat Pre-designed siRNA Set A Pre-designed Set / 否

直系同源

种属 基因名 来源 基因 ID
Homo sapiens Ucp2 NCBI NCBI:7351
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