2. Gene
  3. Ugcg - UDP-glucose ceramide glucosyltransferase Gene

Ugcg - UDP-glucose ceramide glucosyltransferase Gene

  • 基因
  • 蛋白
  • 相关产品
  • 直系同源

中文名称：UDP-葡萄糖神经酰胺葡糖基转移酶

种属: Mus musculus

同用名: Ugcgl; Epcs21; GlcT-1

基因 ID: 22234 | 基因类型: protein coding

关于 Ugcg

Chromosome 4: 59,189,257-59,222,833 forward strand.GRCm39:CM000997.3

This gene has 4 transcripts (splice variants), 212 orthologues and is associated with 13 phenotypes. Ubiquitous expression in CNS E18 (RPKM 2.2), whole brain E14.5 (RPKM 18.2) and 28 other tissues.

功能概要

该基因编码的蛋白可启动神经酰胺葡糖基转移酶活性。涉及多个过程，包括角化信封组装；葡萄糖神经酰胺生物合成过程；和皮肤发育。预测位于高尔基体膜。预计是膜的组成部分。预测在膜中有活性。以多种结构表达，包括囊胚；脑;早期胚胎；肝;和卵母细胞。与人 UGCG（UDP-葡萄糖神经酰胺葡糖基转移酶）同源。 [由基因组资源联盟提供，2022 年 4 月]

Enables ceramide glucosyltransferase activity. Involved in several processes, including cornified envelope assembly; glucosylceramide biosynthetic process; and skin development. Predicted to be located in Golgi membrane. Predicted to be integral component of membrane. Predicted to be active in membrane. Is expressed in several structures, including blastocyst; brain; early embryo; liver; and oocyte. Orthologous to human UGCG (UDP-glucose ceramide glucosyltransferase). [provided by Alliance of Genome Resources, Apr 2022]

Ugcg 基因产物(1)

mRNA Protein Name
NM_011673.3 NP_035803.1 ceramide glucosyltransferase
基因本体论
  • 分子功能
  • 生物过程
分子功能 GO 注释 逻辑证据 参考文献 来源
enables ceramide glucosyltransferase activity IMP
IMP: 通过突变表型推断
10430909 MGI
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in cell differentiation IMP
IMP: 通过突变表型推断
10430909 MGI
involved in cornified envelope assembly IMP
IMP: 通过突变表型推断
23748427 MGI
involved in establishment of skin barrier IMP
IMP: 通过突变表型推断
17145749 MGI
involved in glucosylceramide biosynthetic process IMP
IMP: 通过突变表型推断
10430909 MGI
involved in intestinal lipid absorption IMP
IMP: 通过突变表型推断
22851168 MGI
involved in keratinocyte differentiation IMP
IMP: 通过突变表型推断
23748427 MGI
involved in leptin-mediated signaling pathway IMP
IMP: 通过突变表型推断
23554574 MGI
involved in neuron development IMP
IMP: 通过突变表型推断
16109770 MGI
involved in protein lipidation IMP
IMP: 通过突变表型推断
23748427 MGI
involved in regulation of signal transduction IMP
IMP: 通过突变表型推断
23554574 MGI
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

Ugcg 蛋白结构

Glucosylceramide_synthase

Glucosylceramide_synthase: cd02520 (50 - 279)

  • 0
  • 100
  • 200
  • 300
  • 394 a.a.
蛋白主名 其他名称

ceramide glucosyltransferase

GCS

UDP-glucose:N-acylsphingosine D-glucosyltransferase

ectoplacental cone, invasive trophoblast giant cells, extraembryonic ectoderm and chorion sequence 21

glucosylceramide synthase

glycosylceramide synthase

相关产品

Clinical Phase
生物活性分子 (2)
目录号 产品名 作用方式
纯度 Phase
HY-132596 Tivanisiran Inhibitor 97.48% Phase 3
HY-148100 Emapticap pegol Inhibitor 91.38% Phase 2
Pre-clinical Phase
生物活性分子 (3)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS15419 UGCG Human Pre-designed siRNA Set A Pre-designed Set / 否
HY-RS15420 Ugcg Mouse Pre-designed siRNA Set A Pre-designed Set / 否
HY-RS15421 Ugcg Rat Pre-designed siRNA Set A Pre-designed Set / 否

直系同源

种属 基因名 来源 基因 ID
Homo sapiens Ugcg NCBI NCBI:7357
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