2. Gene
  3. Nr1h2 - nuclear receptor subfamily 1, group H, member 2 Gene

Nr1h2 - nuclear receptor subfamily 1, group H, member 2 Gene

  • 基因
  • 蛋白
  • 相关产品
  • 直系同源

种属: Mus musculus

同用名: UR; LXR; Unr; LXRB; NER1; OR-1; Unr2; RIP15; LXRBSV; LXRbeta

基因 ID: 22260 | 基因类型: protein coding

关于 Nr1h2

功能概要

Enables DNA binding activity; nuclear receptor activity; and retinoid X receptor binding activity. Involved in several processes, including Cholesterol homeostasis; positive regulation of transport; and regulation of transcription by RNA polymerase II. Acts upstream of or within cellular lipid metabolic process and regulation of transcription by RNA polymerase II. Located in nucleus. Is expressed in several structures, including alimentary system; central nervous system; genitourinary system; limb; and sensory organ. Human ortholog(s) of this gene implicated in obesity and type 2 diabetes mellitus. Orthologous to human NR1H2 (nuclear receptor subfamily 1 group H member 2). [provided by Alliance of Genome Resources, Apr 2022]

Nr1h2 基因产物(4)

mRNA Protein Name
NM_001285517.1 NP_001272446.1 oxysterols receptor LXR-beta isoform a
NM_001285518.1 NP_001272447.1 oxysterols receptor LXR-beta isoform b
NM_001285519.1 NP_001272448.1 oxysterols receptor LXR-beta isoform b
NM_009473.3 NP_033499.1 oxysterols receptor LXR-beta isoform a
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables DNA binding IDA
IDA: 通过直接分析推断
14739254 MGI
enables DNA-binding transcription factor activity IDA
IDA: 通过直接分析推断
14739254 MGI
enables DNA-binding transcription factor activity IGI
IGI: 通过遗传相互作用推断
7760852 MGI
enables chromatin DNA binding IDA
IDA: 通过直接分析推断
29431742 MGI
enables nuclear receptor activity IDA
IDA: 通过直接分析推断
14739254 MGI
enables nuclear retinoid X receptor binding IDA
IDA: 通过直接分析推断
7760852 MGI
enables protein binding IPI
IPI: 通过物理相互作用推断
17936707 MGI
生物过程 GO 注释 逻辑证据 参考文献 来源
acts upstream of or within cellular lipid metabolic process IDA
IDA: 通过直接分析推断
14739254 MGI
involved in cholesterol homeostasis IDA
IDA: 通过直接分析推断
17657314 MGI
involved in cholesterol homeostasis IMP
IMP: 通过突变表型推断
18055760 MGI
involved in lipid homeostasis IMP
IMP: 通过突变表型推断
18806227 MGI
involved in negative regulation of cold-induced thermogenesis IGI
IGI: 通过遗传相互作用推断
21173252 MGI
involved in negative regulation of proteolysis IMP
IMP: 通过突变表型推断
18806227 MGI
involved in negative regulation of response to endoplasmic reticulum stress IDA
IDA: 通过直接分析推断
24206663 MGI
involved in negative regulation of transcription by RNA polymerase II IMP
IMP: 通过突变表型推断
20388921 MGI
involved in phosphatidylcholine acyl-chain remodeling IMP
IMP: 通过突变表型推断
24206663 MGI
involved in positive regulation of cholesterol efflux IDA
IDA: 通过直接分析推断
16825483 MGI
acts upstream of or within positive regulation of cholesterol efflux IGI
IGI: 通过遗传相互作用推断
23931754 MGI
involved in positive regulation of high-density lipoprotein particle assembly IDA
IDA: 通过直接分析推断
16825483 MGI
involved in positive regulation of lipid storage IMP
IMP: 通过突变表型推断
18806227 MGI
acts upstream of positive regulation of miRNA transcription IDA
IDA: 通过直接分析推断
31501273 MGI
involved in positive regulation of pancreatic juice secretion IMP
IMP: 通过突变表型推断
18806227 MGI
involved in positive regulation of secretion of lysosomal enzymes IMP
IMP: 通过突变表型推断
18806227 MGI
involved in positive regulation of transcription by RNA polymerase II IDA
IDA: 通过直接分析推断
16141411 MGI
acts upstream of or within regulation of DNA-templated transcription IDA
IDA: 通过直接分析推断
14739254 MGI
acts upstream of or within regulation of transcription by RNA polymerase II IGI
IGI: 通过遗传相互作用推断
7760852 MGI
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in nucleus IDA
IDA: 通过直接分析推断
18806227 MGI
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断
蛋白主名 其他名称

oxysterols receptor LXR-beta

LXR beta

liver X receptor beta

retinoid X receptor-interacting protein No.15

ubiquitously-expressed nuclear receptor 2

相关产品

Pre-clinical Phase
生物活性分子 (3)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS09529 NR1H2 Human Pre-designed siRNA Set A / 否
HY-RS19726 Nr1h2 Mouse Pre-designed siRNA Set A Pre-designed Set / 否
HY-RS26222 Nr1h2 Rat Pre-designed siRNA Set A Pre-designed Set / 否

直系同源

种属 基因名 来源 基因 ID
Homo sapiens Nr1h2 NCBI NCBI:7376
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