1. Gene
  2. FGF6 - fibroblast growth factor 6 Gene

FGF6 - fibroblast growth factor 6 Gene

中文名称:成纤维细胞生长因子 6

种属: Homo sapiens

同用名: HST2; HBGF-6

基因 ID: 2251 | 基因类型: protein coding

关于 FGF6

Cytogenetic location: 12p13.32 Genomic coordinates (GRCh38): 12:4,434,142-4,445,815 (from NCBI)

This gene has 3 transcripts (splice variants), 269 orthologues and 21 paralogues. Low expression observed in reference dataset.

功能概要

该基因编码的蛋白质是成纤维细胞生长因子 (FGF) 家族的成员。 FGF 家族成员具有广泛的促有丝分裂和细胞存活活性,并参与多种生物过程,包括胚胎发育、细胞生长、形态发生、组织修复、肿瘤生长和侵袭。当转染到哺乳动物细胞中时,该基因显示出致癌转化活性。该基因的小鼠同系物主要在肌源性谱系中表现出受限的表达谱,这表明在肌肉再生或分化中起作用。[RefSeq 提供,2008 年 7 月]

The protein encoded by this gene is a member of the Fibroblast Growth Factor (FGF) family. FGF Family members possess broad mitogenic and cell survival activities, and are involved in a variety of biological processes, including embryonic development, cell growth, morphogenesis, tissue repair, tumor growth and invasion. This gene displayed oncogenic transforming activity when transfected into mammalian cells. The mouse homolog of this gene exhibits a restricted expression profile predominantly in the myogenic lineage, which suggested a role in muscle regeneration or differentiation. [provided by RefSeq, Jul 2008]

FGF6 基因产物(1)

mRNA Protein Name
NM_020996.3 NP_066276.2 fibroblast growth factor 6 precursor

FGF6 蛋白结构

FGF

FGF: Fibroblast growth factor (84 - 205)

  • 0
  • 100
  • 208 a.a.
蛋白主名 其他名称

fibroblast growth factor 6

FGF-6

重组 FGF6 蛋白

目录号 产品名 蛋白编号 纯度
HY-P7174 FGF-6 Protein, Human P10767 (G41-I208) ≥95%
HY-P7174A FGF-6 Protein, Human (His) P10767 (G41-I208) ≥95%
HY-P700068AF Animal-Free FGF-6 Protein, Human (His) P10767 (G41-I208) ≥95%

关联疾病

疾病名称 别名
Apert Syndrome

Acrocephalosyndactyly Type I

Acs1

Acrocephalosyndactylia

Acrocephalosyndactyly

Acs I

Apert-Crouzon Disease

Acrocephalosyndactyly Type 1

Acrocephalosyndactyly, Type I

Acs 1

Acrocephalo-Syndactyly Type 1

Syndactylic Oxycephaly

Apert'S Syndrome

Type I Acrocephalosyndactyly

APRS

Nasal Cavity Adenocarcinoma

Adenocarcinoma Of Nasal Cavity

Adenocarcinoma Of The Nasal Cavity

Breast Cancer

Breast Carcinoma

Male Breast Cancer

Breast Cancer, Familial

Malignant Neoplasm Of Breast

Breast Cancer, Susceptibility To

Breast Cancer, Early-Onset

Malignant Tumor Of Breast

Carcinoma Of Male Breast

Breast Cancer, Invasive Ductal

Breast Cancer, Protection Against

Breast Cancer, Somatic

Breast Cancer, Male

Breast Cancer, Lobular, Somatic

Breast Tumor

Mammary Cancer

Mammary Tumor

Malignant Neoplasm Of Male Breast

Mammary Carcinoma

Male Breast Carcinoma

Familial Cancer Of Breast

Invasive Ductal Breast Carcinoma

Breast Cancer Susceptibility

Breast Cancer, Male, Susceptibility To

Breast Cancer, Early-Onset, Susceptibility To

Malignant Tumor Of The Breast

Mammary Neoplasm

Primary Breast Cancer

Neoplasm Of Male Breast

Carcinoma Of Breast

Breast Cancer In Men

Familial Breast Cancer

Cancer Of Breast

BC

Breast Cancer Familial

Breast Cancer Familial Male

Breast Cancer, Familial Male

Breast Male Carcinoma

Breast Neoplasms

Breast Neoplasms, Male

Mammary Tumors

Mammary Carcinomas

Cancer, Breast

Cancer, Breast, Susceptibility

Invasive Breast Ductal Carcinoma

Breast Neoplasm

Susceptibility To Breast Cancer

Mammary Neoplasms

Animal Mammary Neoplasms

Primary Malignant Neoplasm Of Breast

Infiltrating Ductal Carcinoma Of Breast

Infiltrating Duct Carcinoma Of Unspecified Site

Infiltrating Ductular Carcinoma Of Unspecified Site

Invasive Breast Carcinoma Of No Special Type

Microinvasive Carcinoma Of Breast

Carcinoma With Apocrine Differentiation

疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

直系同源

种属 基因名 来源 基因 ID
Mus musculus FGF6 MGD MGI:95520
Felis catus FGF6 VGNC VGNC:62254
Canis familiaris FGF6 VGNC VGNC:40852
Bos taurus FGF6 VGNC VGNC:28981
Rattus norvegicus FGF6 RGD RGD:620130
Macaca mulatta FGF6 VGNC VGNC:108343