2. Gene
  3. Xpa - xeroderma pigmentosum, complementation group A Gene

Xpa - xeroderma pigmentosum, complementation group A Gene

  • 基因
  • 蛋白
  • 相关产品
  • 直系同源

种属: Mus musculus

同用名: Xpac

基因 ID: 22590 | 基因类型: protein coding

关于 Xpa

功能概要

Predicted to enable DNA binding activity; protein domain specific binding activity; and protein homodimerization activity. Acts upstream of or within several processes, including intrinsic apoptotic signaling pathway in response to DNA damage; nucleotide-excision repair; and positive regulation of transcription initiation from RNA polymerase II promoter. Located in nucleus. Is expressed in forelimb bud. Used to study xeroderma pigmentosum group A. Human ortholog(s) of this gene implicated in xeroderma pigmentosum and xeroderma pigmentosum group A. Orthologous to human XPA (XPA, DNA damage recognition and repair factor). [provided by Alliance of Genome Resources, Apr 2022]

Xpa 基因产物(1)

mRNA Protein Name
NM_011728.2 NP_035858.2 DNA repair protein complementing XP-A cells homolog
基因本体论
  • 生物过程
  • 细胞组分
生物过程 GO 注释 逻辑证据 参考文献 来源
acts upstream of or within DNA repair IMP
IMP: 通过突变表型推断
9661901 MGI
acts upstream of or within intrinsic apoptotic signaling pathway in response to DNA damage IMP
IMP: 通过突变表型推断
11005836 MGI
acts upstream of or within multicellular organism growth IGI
IGI: 通过遗传相互作用推断
22323595 MGI
acts upstream of or within nucleotide-excision repair IMP
IMP: 通过突变表型推断
11950998 MGI
acts upstream of or within positive regulation of transcription initiation by RNA polymerase II IGI
IGI: 通过遗传相互作用推断
22323595 MGI
acts upstream of or within regulation of autophagy IMP
IMP: 通过突变表型推断
18443001 MGI
acts upstream of or within response to UV IMP
IMP: 通过突变表型推断
10843671 MGI
acts upstream of or within response to oxidative stress IMP
IMP: 通过突变表型推断
11950998 MGI
acts upstream of or within response to toxic substance IMP
IMP: 通过突变表型推断
11408355 MGI
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in nucleus IDA
IDA: 通过直接分析推断
12815074 MGI
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断
蛋白主名 其他名称

DNA repair protein complementing XP-A cells homolog

xeroderma pigmentosum group A-complementing protein homolog

相关产品

Pre-clinical Phase
生物活性分子 (5)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-139038 TDRL-X80 99.6% 否
HY-161623 ERCC1/XPA interaction inhibitor 1 Inhibitor / 否
HY-RS15884 XPA Human Pre-designed siRNA Set A Pre-designed Set / 否
HY-RS22088 Xpa Mouse Pre-designed siRNA Set A Pre-designed Set / 否
HY-RS28608 Xpa Rat Pre-designed siRNA Set A Pre-designed Set / 否

直系同源

种属 基因名 来源 基因 ID
Homo sapiens Xpa NCBI NCBI:7507
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