2. Gene
  3. Xrcc5 - X-ray repair complementing defective repair in Chinese hamster cells 5 Gene

Xrcc5 - X-ray repair complementing defective repair in Chinese hamster cells 5 Gene

  • 基因
  • 蛋白
  • 相关产品
  • 直系同源

种属: Mus musculus

同用名: Ku80; Ku86; CTC85; CTCBF

基因 ID: 22596 | 基因类型: protein coding

关于 Xrcc5

功能概要

Predicted to enable several functions, including nucleic acid binding activity; protein C-terminus binding activity; and ubiquitin protein Ligase binding activity. Predicted to contribute to 5'-deoxyribose-5-phosphate lyase activity and double-stranded telomeric DNA binding activity. Acts upstream of or within several processes, including cellular response to leukemia inhibitory factor; hematopoietic stem cell differentiation; and positive regulation of neurogenesis. Located in cytoplasm and nucleus. Is expressed in thymus primordium. Human ortholog(s) of this gene implicated in chronic obstructive pulmonary disease and multiple myeloma. Orthologous to human XRCC5 (X-ray repair cross complementing 5). [provided by Alliance of Genome Resources, Apr 2022]

Xrcc5 基因产物(3)

mRNA Protein Name
NM_001357519.1 NP_001344448.1 X-ray repair cross-complementing protein 5 isoform 2
NM_001357520.1 NP_001344449.1 X-ray repair cross-complementing protein 5 isoform 2
NM_009533.2 NP_033559.2 X-ray repair cross-complementing protein 5 isoform 1
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables protein binding IPI
IPI: 通过物理相互作用推断
23685356 MGI
生物过程 GO 注释 逻辑证据 参考文献 来源
acts upstream of or within cellular response to leukemia inhibitory factor IEP
IEP: 通过表达模式推断
20439489 MGI
acts upstream of or within double-strand break repair IGI
IGI: 通过遗传相互作用推断
12531011 MGI
acts upstream of or within double-strand break repair IMP
IMP: 通过突变表型推断
12531011 MGI
acts upstream of or within hematopoietic stem cell differentiation IMP
IMP: 通过突变表型推断
17554309 MGI
acts upstream of or within hematopoietic stem cell proliferation IMP
IMP: 通过突变表型推断
17554309 MGI
acts upstream of or within leptotene IMP
IMP: 通过突变表型推断
17010969 MGI
acts upstream of neurogenesis IMP
IMP: 通过突变表型推断
10716994 MGI
acts upstream of or within positive regulation of neurogenesis IMP
IMP: 通过突变表型推断
10716994 MGI
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in cytoplasm IDA
IDA: 通过直接分析推断
12604618 MGI
located in nucleus IDA
IDA: 通过直接分析推断
12604618 MGI
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断
蛋白主名 其他名称

X-ray repair cross-complementing protein 5

ATP-dependent DNA helicase 2 subunit 2

ATP-dependent DNA helicase II 80 kDa subunit

CTC box-binding factor 85 kDa subunit

DNA repair protein XRCC5

Ku p80

ku autoantigen protein p86 homolog

nuclear factor IV

相关产品

Pre-clinical Phase
生物活性分子 (2)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS15900 XRCC5 Human Pre-designed siRNA Set A Pre-designed Set / 否
HY-RS22924 Xrcc5 Mouse Pre-designed siRNA Set A Pre-designed Set / 否

直系同源

种属 基因名 来源 基因 ID
Homo sapiens Xrcc5 NCBI NCBI:7520
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