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  3. Rorb - RAR-related orphan receptor beta Gene

Rorb - RAR-related orphan receptor beta Gene

  • 基因
  • 蛋白
  • 相关产品
  • 直系同源

中文名称：RAR 相关孤儿受体 β

种属: Mus musculus

同用名: RZRB; hstp; Nr1f2; Rorbeta; RZR-beta

基因 ID: 225998 | 基因类型: protein coding

关于 Rorb

Chromosome 19: 18,907,969-19,088,560 reverse strand.GRCm39:CM001012.3

This gene has 5 transcripts (splice variants), 398 orthologues, 19 paralogues and is associated with 36 phenotypes. Biased expression in cortex adult (RPKM 5.3), frontal lobe adult (RPKM 2.8) and 5 other tissues.

功能概要

该基因编码的蛋白质是核激素受体 NR1 亚家族的成员。它是一种 DNA 结合蛋白，可以作为单体或作为同型二聚体与几个基因上游的激素反应元件结合，以增强这些基因的表达。编码的蛋白质已被证明与 NM23-2 相互作用，NM23-2 是一种参与器官发生和分化的核苷二磷酸激酶，并有助于调节一些与昼夜节律有关的基因的表达。已发现该基因的三个转录变体编码不同的亚型。 [RefSeq 提供，2014 年 2 月]

The protein encoded by this gene is a member of the NR1 subfamily of nuclear hormone receptors. It is a DNA-binding protein that can bind as a monomer or as a homodimer to hormone response elements upstream of several genes to enhance the expression of those genes. The encoded protein has been shown to interact with NM23-2, a nucleoside diphosphate kinase involved in organogenesis and differentiation, and to help regulate the expression of some genes involved in circadian rhythm. Three transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Feb 2014]

Rorb 基因产物(3)

mRNA Protein Name
NM_001043354.2 NP_001036819.1 nuclear receptor ROR-beta isoform 1
NM_001289921.1 NP_001276850.1 nuclear receptor ROR-beta isoform 3
NM_146095.4 NP_666207.3 nuclear receptor ROR-beta isoform 2
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables DNA-binding transcription activator activity, RNA polymerase II-specific IDA
IDA: 通过直接分析推断
16574740 MGI
enables DNA-binding transcription factor activity IDA
IDA: 通过直接分析推断
16574740 MGI
enables DNA-binding transcription factor activity, RNA polymerase II-specific IDA
IDA: 通过直接分析推断
23652001 MGI
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IDA
IDA: 通过直接分析推断
16574740 MGI
enables protein binding IPI
IPI: 通过物理相互作用推断
10860982 MGI
enables sequence-specific DNA binding IDA
IDA: 通过直接分析推断
16574740 MGI
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in amacrine cell differentiation IMP
IMP: 通过突变表型推断
23652001 MGI
involved in eye photoreceptor cell development IMP
IMP: 通过突变表型推断
16574740 MGI
involved in negative regulation of osteoblast differentiation IDA
IDA: 通过直接分析推断
22189870 MGI
involved in positive regulation of DNA-templated transcription IDA
IDA: 通过直接分析推断
16574740 MGI
involved in positive regulation of transcription by RNA polymerase II IDA
IDA: 通过直接分析推断
16574740 MGI
involved in regulation of circadian rhythm IMP
IMP: 通过突变表型推断
17303680 MGI
involved in retina development in camera-type eye IMP
IMP: 通过突变表型推断
23652001 MGI
involved in retinal cone cell development IDA
IDA: 通过直接分析推断
16574740 MGI
involved in retinal rod cell development IMP
IMP: 通过突变表型推断
16574740 MGI
acts upstream of or within retinal rod cell differentiation IMP
IMP: 通过突变表型推断
25296752 MGI
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in nucleus IDA
IDA: 通过直接分析推断
16574740 MGI
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

Rorb 蛋白结构

NR_DBD_ROR

NR_DBD_ROR: cd06968 (2 - 96)

NR_LBD_ROR_like

NR_LBD_ROR_like: cd06939 (209 - 449)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 459 a.a.
蛋白主名 其他名称

nuclear receptor ROR-beta

nuclear receptor RZR-beta

nuclear receptor subfamily 1 group F member 2

retinoid-related orphan receptor-beta

相关产品

Pre-clinical Phase
生物活性分子 (3)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS12129 RORB Human Pre-designed siRNA Set A / 否
HY-RS12130 Rorb Mouse Pre-designed siRNA Set A / 否
HY-RS12131 Rorb Rat Pre-designed siRNA Set A Pre-designed Sets / 否

直系同源

种属 基因名 来源 基因 ID
Homo sapiens Rorb NCBI NCBI:6096
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