2. Gene
  3. FGL1 - fibrinogen like 1 Gene

FGL1 - fibrinogen like 1 Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：纤维蛋白原样 1

种属: Homo sapiens

同用名: HPS; HFREP1; HP-041; LFIRE1; LFIRE-1

基因 ID: 2267 | 基因类型: protein coding

关于 FGL1

Cytogenetic location: 8p22 Genomic coordinates (GRCh38): 8:17,864,389-17,895,538 (from NCBI)

This gene has 11 transcripts (splice variants), 126 orthologues and 25 paralogues. Restricted expression toward liver (RPKM 275.4).

功能概要

纤维蛋白原样 1 是纤维蛋白原家族的一员。该蛋白质与纤维蛋白原β-和γ-亚基的羧基末端同源，后者包含纤维蛋白原和纤维蛋白原相关蛋白的四个保守半胱氨酸。然而，这种蛋白质缺乏血小板结合位点、交联区和凝血酶敏感位点，这些都是纤维蛋白凝块形成所必需的。这种蛋白质可能在肝细胞癌的发展中发挥作用。该基因存在四种编码相同蛋白质的可变剪接转录物变体。[RefSeq 提供，2008 年 7 月]

Fibrinogen-like 1 is a member of the fibrinogen family. This protein is homologous to the carboxy terminus of the fibrinogen beta- and gamma- subunits which contains the four conserved cysteines of fibrinogens and fibrinogen related proteins. However, this protein lacks the platelet-binding site, cross-linking region and a thrombin-sensitive site which are necessary for fibrin clot formation. This protein may play a role in the development of hepatocellular carcinomas. Four alternatively spliced transcript variants encoding the same protein exist for this gene. [provided by RefSeq, Jul 2008]

FGL1 基因产物(4)

mRNA Protein Name
NM_004467.4 NP_004458.3 fibrinogen-like protein 1 precursor
NM_147203.2 NP_671736.2 fibrinogen-like protein 1 precursor
NM_201552.1 NP_963846.1 fibrinogen-like protein 1 precursor
NM_201553.1 NP_963847.1 fibrinogen-like protein 1 precursor

FGL1 蛋白结构

Fibrinogen_C

Fibrinogen_C: Fibrinogen beta and gamma chains, C-terminal globular domain (80 - 304)

  • 0
  • 100
  • 200
  • 312 a.a.
蛋白主名 其他名称

fibrinogen-like protein 1

hepassocin

重组 FGL1 蛋白

目录号 产品名 蛋白编号 纯度
HY-P70737 FGL1 Protein, Human (HEK293, His) Q08830(L23-I312) ≥95%
HY-P70740 FGL1 Protein, Human (HEK293, mFc) Q08830 (L23-I312) ≥95%
HY-P72369 FGL1 Protein, Human (Biotinylated, 290a.a, HEK293, Avi-His) Q08830 (L23-I312) ≥95%
HY-P78128 FGL1 Protein, Human (Biotinylated, 242a.a, HEK293, His-Avi) Q08830 (D64-N305) ≥95%
HY-P78443 FGL1 protein, Human (HEK293, His-Avi) Q08830 (D64-N305) ≥95%
HY-P78875 FGL1 Protein, Human (Biotinylated, 290a.a, HEK293, Fc-Avi) Q08830 (L23-I312) ≥95%
HY-P78876 FGL1 Protein, Human (Biotinylated, 249a.a, HEK293, Fc-Avi) Q08830 (D64-I312) ≥95%
HY-P70740A FGL1 Protein, Human (HEK293, mFc, solution) Q08830 (L23-I312) ≥95%
HY-P701077 FGL1 Protein, Human (Biotinylated, HEK293, hFc) Q08830 (D64-N305) ≥95%

关联疾病

疾病名称 别名
Hepatocellular Carcinoma

Liver Cancer

Primary Liver Cancer

HCC

Hepatoma

Malignant Neoplasm Of Liver

Liver Neoplasms

Cancer, Hepatocellular

Liver Cell Carcinoma

Lcc

Hepatoblastoma, Somatic

Hepatic Cancer

Primary Malignant Neoplasm Of Liver

Rare Tumor Of Liver And Intrahepatic Biliary Tract

Hepatocellular Carcinoma, Somatic

Hepatocellular Carcinoma, Childhood Type, Somatic

Hepatocellular Cancer, Somatic

Ca Liver - Primary

Hepatic Neoplasm

Malignant Hepato-Biliary Neoplasm

Malignant Neoplasm Of Liver, Not Specified As Primary Or Secondary

Malignant Neoplasm Of Liver, Primary

Malignant Tumor Of Liver

Neoplasm Of Liver

Non-Resectable Primary Hepatic Malignant Neoplasm

Resectable Malignant Neoplasm Of Liver

Resectable Malignant Neoplasm Of The Liver

Primary Liver Carcinoma

Primary Malignant Liver Neoplasm

Primary Cancer Of Liver

Primary Tumor Of The Liver

Rare Tumor Of Liver And Ibt

Hepatocellular Cancer

Neoplasm Of The Liver

Carcinoma, Hepatocellular

Hepatomas

Liver Neoplasm

Liver Carcinoma

Liver And Intrahepatic Biliary Tract Carcinoma

Malignant Hepatobiliary Neoplasm

Adult Primary Hepatocellular Carcinoma

Hepatoblastoma

Carcinoma Of Liver

Malignant Liver Tumour

Malignant Hepatic Tumour
Lung Cancer

Lung Carcinoma

Non-Small Cell Lung Carcinoma

Lung Cancer, Susceptibility To

Lung Cancer, Protection Against

Adenocarcinoma Of Lung, Somatic

Adenocarcinoma Of Lung, Response To Tyrosine Kinase Inhibitor In

Nonsmall Cell Lung Cancer

Lung Neoplasm

Carcinoma Of Lung

Lung Non-Small Cell Carcinoma

Non-Small Cell Lung Cancer

Nsclc

Lung Neoplasms

Malignant Neoplasm Of Lung

Alveolar Cell Carcinoma

Nonsmall Cell Lung Cancer, Somatic

Nonsmall Cell Lung Cancer, Response To Tyrosine Kinase Inhibitor In

Nonsmall Cell Lung Cancer, Susceptibility To

Lung Cancer, Somatic

Lung Cancer, Resistance To

Cancer Of Lung

Cancer Of Bronchus

Cancer Of The Lung

Lung Malignancies

Lung Malignant Tumors

Malignant Lung Tumor

Malignant Tumor Of Lung

Pulmonary Cancer

Pulmonary Carcinoma

Pulmonary Neoplasms

Respiratory Carcinoma

LNCR

Adenocarcinoma Of Lung

Neoplasm Of Lung

Cancer Lung

Carcinoma Non-Small Cell Lung

Carcinoma, Non-Small-Cell Lung

Lung Cancers

Lung Carcinomas

Cancer, Lung

Cancer, Lung, Non-Small Cell

Primary Malignant Neoplasm Of Lung

Bronchioloalveolar Adenocarcinoma
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Clinical Phase
抗体抑制剂 (1)
目录号 产品名 作用方式
纯度 Phase
HY-P99156 Relatlimab 97.78% Phase 3
Pre-clinical Phase
生物活性分子 (1)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS04927 FGL1 Human Pre-designed siRNA Set A / 否

直系同源

种属 基因名 来源 基因 ID
Felis catus FGL1 VGNC VGNC:78497
Rattus norvegicus FGL1 RGD RGD:620169
Mus musculus FGL1 MGD MGI:102795
Bos taurus FGL1 VGNC VGNC:28992
Macaca mulatta FGL1 VGNC VGNC:84000
Canis familiaris FGL1 VGNC VGNC:40864
Macaca fascicularis FGL1 NCBI
Others FGL1 NCBI
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