2. Gene
  3. Gsn - gelsolin Gene

Gsn - gelsolin Gene

  • 基因
  • 蛋白
  • 相关产品
  • 直系同源

种属: Mus musculus

同用名: ADF

基因 ID: 227753 | 基因类型: protein coding

关于 Gsn

功能概要

Enables phosphatidylinositol 3-kinase catalytic subunit binding activity. Involved in several processes, including actin filament capping; actin polymerization or depolymerization; and positive regulation of protein processing in phagocytic vesicle. Acts upstream of or within cellular response to interferon-gamma and vesicle-mediated transport. Located in lamellipodium and phagocytic vesicle. Colocalizes with focal adhesion. Is expressed in several structures, including alimentary system; central nervous system; genitourinary system; heart; and sensory organ. Human ortholog(s) of this gene implicated in Finnish type amyloidosis. Orthologous to human GSN (gelsolin). [provided by Alliance of Genome Resources, Apr 2022]

Gsn 基因产物(7)

mRNA Protein Name
NM_001206367.1 NP_001193296.1 gelsolin isoform 2
NM_001206368.1 NP_001193297.1 gelsolin isoform 2
NM_001206369.1 NP_001193298.1 gelsolin isoform 2
NM_001362945.1 NP_001349874.1 gelsolin isoform 3
NM_001362947.1 NP_001349876.1 gelsolin isoform 3
NM_001362948.1 NP_001349877.1 gelsolin isoform 2
NM_146120.4 NP_666232.2 gelsolin isoform 1 precursor
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables phosphatidylinositol 3-kinase catalytic subunit binding IPI
IPI: 通过物理相互作用推断
30568254 MGI
enables protein binding IPI
IPI: 通过物理相互作用推断
23055941 MGI
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in actin cytoskeleton organization IMP
IMP: 通过突变表型推断
30568254 MGI
involved in actin filament capping IDA
IDA: 通过直接分析推断
23325791 MGI
involved in actin filament depolymerization IMP
IMP: 通过突变表型推断
30568254 MGI
involved in actin filament polymerization IDA
IDA: 通过直接分析推断
23325791 MGI
involved in actin filament severing IMP
IMP: 通过突变表型推断
23325791 MGI
involved in cardiac muscle cell contraction IMP
IMP: 通过突变表型推断
30568254 MGI
acts upstream of or within cellular response to type II interferon IDA
IDA: 通过直接分析推断
19144319 MGI
involved in phagocytosis, engulfment IMP
IMP: 通过突变表型推断
23325791 MGI
involved in positive regulation of protein processing in phagocytic vesicle IMP
IMP: 通过突变表型推断
23325791 MGI
involved in relaxation of cardiac muscle IMP
IMP: 通过突变表型推断
30568254 MGI
involved in response to muscle stretch IMP
IMP: 通过突变表型推断
30568254 MGI
acts upstream of or within vesicle-mediated transport IMP
IMP: 通过突变表型推断
11514591 MGI
细胞组分 GO 注释 逻辑证据 参考文献 来源
colocalizes with focal adhesion IDA
IDA: 通过直接分析推断
23325791 MGI
located in lamellipodium IDA
IDA: 通过直接分析推断
15294161 MGI
located in phagocytic vesicle IDA
IDA: 通过直接分析推断
19144319 MGI
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断
蛋白主名 其他名称

gelsolin

actin-depolymerizing factor

brevin

相关产品

Pre-clinical Phase
生物活性分子 (4)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-133870 Itaconate-alkyne 98.01% 否
HY-RS05867 GSN Human Pre-designed siRNA Set A Pre-designed Set / 否
HY-RS18449 Gsn Mouse Pre-designed siRNA Set A Pre-designed Set / 否
HY-RS24931 Gsn Rat Pre-designed siRNA Set A Pre-designed Set / 否

直系同源

种属 基因名 来源 基因 ID
Homo sapiens Gsn NCBI NCBI:2934
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