2. Gene
  3. MTF2 - metal response element binding transcription factor 2 Gene

MTF2 - metal response element binding transcription factor 2 Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：金属反应元件结合转录因子 2

种属: Homo sapiens

同用名: M96; PCL2; TDRD19A; dJ976O13.2

基因 ID: 22823 | 基因类型: protein coding

关于 MTF2

Cytogenetic location: 1p22.1 Genomic coordinates (GRCh38): 1:93,079,283-93,139,076 (from NCBI)

This gene has 14 transcripts (splice variants), 208 orthologues and 2 paralogues. Ubiquitous expression in testis (RPKM 5.1), lymph node (RPKM 4.5) and 25 other tissues.

功能概要

启用甲基化组蛋白结合活性和转录辅阻遏物结合活性。预计参与多个过程，包括组蛋白 H3-K27 甲基化的调节；通过 RNA 聚合酶 II 调节转录；和段规范。预计在白血病抑制因子的细胞反应上游或细胞反应中起作用。位于细胞质中；粘着斑；和核质。 [由基因组资源联盟提供，2022 年 4 月]

Enables methylated histone binding activity and transcription corepressor binding activity. Predicted to be involved in several processes, including regulation of histone H3-K27 methylation; regulation of transcription by RNA polymerase II; and segment specification. Predicted to act upstream of or within cellular response to Leukemia Inhibitory Factor. Located in cytoplasm; focal adhesion; and nucleoplasm. [provided by Alliance of Genome Resources, Apr 2022]

MTF2 基因产物(4)

mRNA Protein Name
NM_001164391.2 NP_001157863.1 metal-response element-binding transcription factor 2 isoform c
NM_001164392.2 NP_001157864.1 metal-response element-binding transcription factor 2 isoform b
NM_001164393.2 NP_001157865.1 metal-response element-binding transcription factor 2 isoform c
NM_007358.4 NP_031384.1 metal-response element-binding transcription factor 2 isoform a
基因本体论
  • 分子功能
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables methylated histone binding IDA
IDA: 通过直接分析推断
23142980 GOA
enables protein binding IPI
IPI: 通过物理相互作用推断
32296183 GOA
enables transcription corepressor binding IPI
IPI: 通过物理相互作用推断
29628311 GOA
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in cytoplasm IDA
IDA: 通过直接分析推断
8619255 GOA
located in nucleus IDA
IDA: 通过直接分析推断
8619255 GOA
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

MTF2 蛋白结构

PHD

PHD: PHD-finger (104 - 155)

Mtf2_C

Mtf2_C: Polycomb-like MTF2 factor 2 (544 - 592)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 500
  • 593 a.a.
蛋白主名 其他名称

metal-response element-binding transcription factor 2

hPCl2

关联疾病

疾病名称 别名
Non-Syndromic X-Linked Intellectual Disability 14

Mrx14
Retinitis Pigmentosa 48

RP48

Retinitis Pigmentosa, Type 48
Voyeurism
Weaver Syndrome

Wss

Weaver-Smith Syndrome

WVS

Weaver-Like Syndrome

Weaver-Williams Syndrome

Camptodactyly-Overgrowth-Unusual Facies Syndrome

Camptodactyly - Overgrowth - Unusual Facies

Ezh2 Related Overgrowth

Overgrowth Syndrome With Accelerated Skeletal Maturation, Unusual Facies, And Camptodactyly

Weaver Smith Syndrome

Weaver Like Syndrome

Weaver Williams Syndrome

Camptodactyly-Overgrowth-Unusual Facies

Weaver Syndrome 1

Weaver Syndrome 2

Wvs1

Wvs2
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Pre-clinical Phase
生物活性分子 (3)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS08766 MTF2 Human Pre-designed siRNA Set A Pre-designed Set / 否
HY-RS22243 Mtf2 Mouse Pre-designed siRNA Set A Pre-designed Set / 否
HY-RS28765 Mtf2 Rat Pre-designed siRNA Set A Pre-designed Set / 否

直系同源

种属 基因名 来源 基因 ID
Felis catus MTF2 VGNC VGNC:63647
Mus musculus MTF2 MGD MGI:105050
Rattus norvegicus MTF2 RGD RGD:1304727
Bos taurus MTF2 VGNC VGNC:31723
Macaca mulatta MTF2 VGNC VGNC:74858
Canis familiaris MTF2 VGNC VGNC:43467
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