2. Gene
  3. PPM1E - protein phosphatase, Mg2+/Mn2+ dependent 1E Gene

PPM1E - protein phosphatase, Mg2+/Mn2+ dependent 1E Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：蛋白磷酸酶，Mg2+/Mn2+ 依赖性 1E

种属: Homo sapiens

同用名: POPX1; PP2CH; caMKN; CAMKPN; CaMKP-N

基因 ID: 22843 | 基因类型: protein coding

关于 PPM1E

Cytogenetic location: 17q22 Genomic coordinates (GRCh38): 17:58,755,854-58,985,179 (from NCBI)

This gene has 1 transcript (splice variant), 207 orthologues and 16 paralogues. Biased expression in brain (RPKM 6.5), testis (RPKM 3.8) and 3 other tissues.

功能概要

该基因编码丝氨酸/苏氨酸蛋白磷酸酶 PPM 家族的成员。编码的蛋白质定位于细胞核并使多种底物去磷酸化和失活，包括丝氨酸/苏氨酸蛋白激酶 PAK 1、5'-AMP 活化蛋白激酶 (AMPK) 和多功能钙/钙调蛋白依赖性蛋白激酶。已观察到该基因的可变剪接转录物变体。[RefSeq 提供，2012 年 5 月]

This gene encodes a member of the PPM family of serine/threonine-protein phosphatases. The encoded protein is localized to the nucleus and dephosphorylates and inactivates multiple substrates including serine/threonine-protein kinase PAK 1, 5'-AMP-activated protein kinase (AMPK) and the multifunctional calcium/calmodulin-dependent protein kinases. Alternatively spliced transcript variants have been observed for this gene. [provided by RefSeq, May 2012]

PPM1E 基因产物(1)

mRNA Protein Name
NM_014906.5 NP_055721.3 protein phosphatase 1E
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables protein binding IPI
IPI: 通过物理相互作用推断
11864573 GOA
enables protein serine/threonine phosphatase activity IDA
IDA: 通过直接分析推断
20801214 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in cellular response to lipopolysaccharide IMP
IMP: 通过突变表型推断
27793001 GOA
involved in cellular response to xenobiotic stimulus IDA
IDA: 通过直接分析推断
20801214 GOA
involved in negative regulation of protein kinase activity IDA
IDA: 通过直接分析推断
11864573 GOA
involved in peptidyl-threonine dephosphorylation IDA
IDA: 通过直接分析推断
20801214 GOA
involved in positive regulation of stress fiber assembly IDA
IDA: 通过直接分析推断
11864573 GOA
细胞组分 GO 注释 逻辑证据 参考文献 来源
part of protein-containing complex IDA
IDA: 通过直接分析推断
11864573 GOA
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

PPM1E 蛋白结构

PP2C

PP2C: Protein phosphatase 2C (233 - 481)

  • 0
  • 200
  • 400
  • 600
  • 755 a.a.
蛋白主名 其他名称

protein phosphatase 1E

ca(2+)/calmodulin-dependent protein kinase phosphatase N

PPM1E 抗体

目录号 产品名 应用 反应物种
HY-P87013 PPM1E Antibody (YA6706) WB Human

关联疾病

疾病名称 别名
Mulibrey Nanism

MUL

Muscle-Liver-Brain-Eye Nanism

Pericardial Constriction And Growth Failure

Perheentupa Syndrome

Mulibrey Growth Disorder

Mulibrey Nanism Syndrome

Pericardial Constriction With Growth Failure

Nanism Mulibrey
Osteoblastoma
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Pre-clinical Phase
生物活性分子 (3)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS10963 PPM1E Human Pre-designed siRNA Set A Pre-designed Set / 否
HY-RS21029 Ppm1e Mouse Pre-designed siRNA Set A Pre-designed Set / 否
HY-RS27546 Ppm1e Rat Pre-designed siRNA Set A Pre-designed Set / 否

直系同源

种属 基因名 来源 基因 ID
Bos taurus PPM1E VGNC VGNC:33211
Rattus norvegicus PPM1E RGD RGD:735028
Felis catus PPM1E VGNC VGNC:99323
Macaca mulatta PPM1E VGNC VGNC:76073
Canis familiaris PPM1E VGNC VGNC:44865
Mus musculus PPM1E MGD MGI:2444096
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