FKBP2 - FKBP prolyl isomerase 2 Gene

中文名称：FKBP 脯氨酰异构酶 2

种属: Homo sapiens

同用名: FKBP13; PPIase; FKBP-13

关于 FKBP2

功能概要

该基因编码的蛋白质是免疫亲和蛋白家族的成员，它在免疫调节和涉及蛋白质折叠和运输的基本细胞过程中发挥作用。这种编码的蛋白质是一种顺反式脯氨酰异构酶，可结合免疫抑制剂 FK506 和雷帕霉素。它被认为可以作为 ER 伴侣发挥作用，也可以作为膜细胞骨架支架的一个组成部分。已经鉴定出编码相同蛋白质的多个可变剪接变体。[RefSeq 提供，2008 年 9 月]

The protein encoded by this gene is a member of the immunophilin protein family, which play a role in immunoregulation and basic cellular processes involving protein folding and trafficking. This encoded protein is a cis-trans prolyl isomerase that binds the immunosuppressants FK506 and rapamycin. It is thought to function as an ER chaperone and may also act as a component of membrane cytoskeletal scaffolds. Multiple alternatively spliced variants, encoding the same protein, have been identified. [provided by RefSeq, Sep 2008]