2. Gene
  3. Asxl1 - ASXL transcriptional regulator 1 Gene

Asxl1 - ASXL transcriptional regulator 1 Gene

  • 基因
  • 蛋白
  • 相关产品
  • 直系同源

种属: Mus musculus

基因 ID: 228790 | 基因类型: protein coding

关于 Asxl1

功能概要

Enables peroxisome proliferator activated receptor binding activity; retinoic acid receptor binding activity; and transcription coactivator activity. Involved in several processes, including kidney development; negative regulation of fat cell differentiation; and regulation of signal transduction. Acts upstream of or within animal organ development; cell morphogenesis; and homeostasis of number of cells. Located in nucleus. Is expressed in several structures, including limb bud; lung; nervous system; paraxial mesenchyme; and salivary gland. Used to study acute myeloid leukemia; myelodysplastic syndrome; and myeloproliferative neoplasm. Human ortholog(s) of this gene implicated in SM-AHNMD; acute myeloid leukemia; chronic myelomonocytic leukemia; myelodysplastic syndrome; and myelofibrosis. Orthologous to human ASXL1 (ASXL transcriptional regulator 1). [provided by Alliance of Genome Resources, Apr 2022]

Asxl1 基因产物(1)

mRNA Protein Name
NM_001039939.2 NP_001035028.1 polycomb group protein ASXL1
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables nuclear retinoic acid receptor binding IDA
IDA: 通过直接分析推断
16606617 MGI
enables peroxisome proliferator activated receptor binding IDA
IDA: 通过直接分析推断
21047783 MGI
enables protein binding IPI
IPI: 通过物理相互作用推断
16606617 MGI
enables transcription coactivator activity IDA
IDA: 通过直接分析推断
16606617 MGI
生物过程 GO 注释 逻辑证据 参考文献 来源
acts upstream of or within animal organ morphogenesis IMP
IMP: 通过突变表型推断
19861679 MGI
acts upstream of or within bone development IMP
IMP: 通过突变表型推断
22876197 MGI
acts upstream of or within bone marrow development IMP
IMP: 通过突变表型推断
19861679 MGI
acts upstream of or within cell morphogenesis IMP
IMP: 通过突变表型推断
19861679 MGI
acts upstream of or within heart morphogenesis IMP
IMP: 通过突变表型推断
24860998 MGI
acts upstream of or within hematopoietic or lymphoid organ development IMP
IMP: 通过突变表型推断
19861679 MGI
acts upstream of or within hemopoiesis IMP
IMP: 通过突变表型推断
19861679 MGI
acts upstream of or within homeostasis of number of cells IMP
IMP: 通过突变表型推断
19861679 MGI
acts upstream of or within lung saccule development IMP
IMP: 通过突变表型推断
24860998 MGI
involved in negative regulation of fat cell differentiation IDA
IDA: 通过直接分析推断
21047783 MGI
involved in negative regulation of peroxisome proliferator activated receptor signaling pathway IDA
IDA: 通过直接分析推断
21047783 MGI
involved in podocyte development IMP
IMP: 通过突变表型推断
26385183 MGI
involved in positive regulation of retinoic acid receptor signaling pathway IDA
IDA: 通过直接分析推断
16606617 MGI
involved in positive regulation of transcription by RNA polymerase II IDA
IDA: 通过直接分析推断
16606617 MGI
involved in regulation of kidney size IMP
IMP: 通过突变表型推断
26385183 MGI
involved in response to retinoic acid IDA
IDA: 通过直接分析推断
16606617 MGI
acts upstream of or within thymus development IMP
IMP: 通过突变表型推断
19861679 MGI
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in nucleus IDA
IDA: 通过直接分析推断
24216483 MGI
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断
蛋白主名 其他名称

polycomb group protein ASXL1

additional sex combs like 1

additional sex combs-like protein 1

putative Polycomb group protein ASXL1

相关产品

Pre-clinical Phase
生物活性分子 (4)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-W327122 BAP1-IN-1 Inhibitor 99.86% 否
HY-RS01114 ASXL1 Human Pre-designed siRNA Set A Pre-designed Set / 否
HY-RS17970 Asxl1 Mouse Pre-designed siRNA Set A Pre-designed Set / 否
HY-RS24441 Asxl1 Rat Pre-designed siRNA Set A Pre-designed Set / 否

直系同源

种属 基因名 来源 基因 ID
Homo sapiens Asxl1 NCBI NCBI:171023
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