2. Gene
  3. CARD8 - caspase recruitment domain family member 8 Gene

CARD8 - caspase recruitment domain family member 8 Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：胱天蛋白酶招募域家族成员 8

种属: Homo sapiens

同用名: NDPP; DACAR; DAKAR; NDPP1; TUCAN; CARDINAL

基因 ID: 22900 | 基因类型: protein coding

关于 CARD8

Cytogenetic location: 19q13.33 Genomic coordinates (GRCh38): 19:48,179,825-48,255,946 (from NCBI)

This gene has 31 transcripts (splice variants), 96 orthologues and is associated with 1 phenotype. Broad expression in spleen (RPKM 13.6), lymph node (RPKM 11.5) and 24 other tissues.

功能概要

该基因编码的蛋白质属于含有半胱天冬酶募集结构域 (CARD) 的蛋白质家族，参与导致半胱天冬酶或核因子 kappa-B (NFKB) 激活的通路。这种蛋白质可能是炎症小体的组成部分，炎症小体是一种蛋白质复合物，在促炎半胱天冬酶的激活中发挥作用。据认为，这种蛋白质作为衔接分子，负向调节 NFKB 激活、CASP1 依赖性 IL1B 分泌和细胞凋亡。该基因的多态性可能与类风湿性关节炎的易感性有关。已经描述了该基因的可变剪接转录物变体。[RefSeq 提供，2010 年 5 月]

The protein encoded by this gene belongs to the Caspase recruitment domain (CARD)-containing family of proteins, which are involved in pathways leading to activation of caspases or nuclear factor kappa-B (NFKB). This protein may be a component of the inflammasome, a protein complex that plays a role in the activation of proinflammatory caspases. It is thought that this protein acts as an adaptor molecule that negatively regulates NFKB activation, CASP1-dependent IL1B secretion, and Apoptosis. Polymorphisms in this gene may be associated with a susceptibility to rheumatoid arthritis. Alternatively spliced transcript variants have been described for this gene. [provided by RefSeq, May 2010]

CARD8 基因产物(17)

mRNA Protein Name
NM_001184900.3 NP_001171829.1 caspase recruitment domain-containing protein 8 isoform a
NM_001184901.1 NP_001171830.1 caspase recruitment domain-containing protein 8 isoform b
NM_001184902.2 NP_001171831.1 caspase recruitment domain-containing protein 8 isoform c
NM_001184903.1 NP_001171832.1 caspase recruitment domain-containing protein 8 isoform c
NM_001184904.2 NP_001171833.1 caspase recruitment domain-containing protein 8 isoform d
NM_001351782.2 NP_001338711.1 caspase recruitment domain-containing protein 8 isoform a
NM_001351783.2 NP_001338712.1 caspase recruitment domain-containing protein 8 isoform b
NM_001351784.2 NP_001338713.1 caspase recruitment domain-containing protein 8 isoform e
NM_001351786.2 NP_001338715.1 caspase recruitment domain-containing protein 8 isoform f
NM_001351787.2 NP_001338716.1 caspase recruitment domain-containing protein 8 isoform g
NM_001351788.2 NP_001338717.1 caspase recruitment domain-containing protein 8 isoform h
NM_001351789.2 NP_001338718.1 caspase recruitment domain-containing protein 8 isoform h
NM_001351790.2 NP_001338719.1 caspase recruitment domain-containing protein 8 isoform i
NM_001351791.2 NP_001338720.1 caspase recruitment domain-containing protein 8 isoform j
NM_001351792.2 NP_001338721.1 caspase recruitment domain-containing protein 8 isoform j
NM_001365950.1 NP_001352879.1 caspase recruitment domain-containing protein 8 isoform k
NM_014959.5 NP_055774.2 caspase recruitment domain-containing protein 8 isoform b
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables CARD domain binding IPI
IPI: 通过物理相互作用推断
11821383 GOA
enables NACHT domain binding IPI
IPI: 通过物理相互作用推断
15030775 GOA
enables cysteine-type endopeptidase activator activity IDA
IDA: 通过直接分析推断
15030775 GOA
enables endopeptidase activity IDA
IDA: 通过直接分析推断
22087307 GOA
enables molecular condensate scaffold activity IDA
IDA: 通过直接分析推断
33053349 GOA
enables pattern recognition receptor activity IDA
IDA: 通过直接分析推断
33542150 GOA
enables protein binding IPI
IPI: 通过物理相互作用推断
11551959 GOA
enables protein homodimerization activity IDA
IDA: 通过直接分析推断
15030775 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in CARD8 inflammasome complex assembly IDA
IDA: 通过直接分析推断
31525884 GOA
involved in antiviral innate immune response IDA
IDA: 通过直接分析推断
33542150 GOA
involved in defense response to virus IDA
IDA: 通过直接分析推断
33542150 GOA
involved in inhibition of cysteine-type endopeptidase activity IDA
IDA: 通过直接分析推断
11821383 GOA
involved in negative regulation of NF-kappaB transcription factor activity IMP
IMP: 通过突变表型推断
11821383 GOA
involved in negative regulation of NLRP3 inflammasome complex assembly IDA
IDA: 通过直接分析推断
24517500 GOA
involved in negative regulation of canonical NF-kappaB signal transduction IDA
IDA: 通过直接分析推断
11551959 GOA
involved in negative regulation of interleukin-1 beta production IDA
IDA: 通过直接分析推断
11821383 GOA
involved in negative regulation of lipopolysaccharide-mediated signaling pathway IDA
IDA: 通过直接分析推断
11821383 GOA
involved in negative regulation of tumor necrosis factor-mediated signaling pathway IMP
IMP: 通过突变表型推断
11821383 GOA
involved in positive regulation of cysteine-type endopeptidase activity involved in apoptotic process IDA
IDA: 通过直接分析推断
11821383 GOA
involved in positive regulation of interleukin-1 beta production IDA
IDA: 通过直接分析推断
15030775 GOA
involved in protein homooligomerization IDA
IDA: 通过直接分析推断
33420028 GOA
involved in pyroptotic inflammatory response IDA
IDA: 通过直接分析推断
32840892 GOA
involved in self proteolysis IDA
IDA: 通过直接分析推断
33542150 GOA
细胞组分 GO 注释 逻辑证据 参考文献 来源
part of CARD8 inflammasome complex IDA
IDA: 通过直接分析推断
15030775 GOA
part of NLRP3 inflammasome complex IDA
IDA: 通过直接分析推断
15030775 GOA
part of canonical inflammasome complex IDA
IDA: 通过直接分析推断
34019797 GOA
is active in cytoplasm IDA
IDA: 通过直接分析推断
24517500 GOA
located in cytoplasm IDA
IDA: 通过直接分析推断
15030775 GOA
located in nucleus IDA
IDA: 通过直接分析推断
11551959 GOA
part of protein-containing complex IDA
IDA: 通过直接分析推断
11821383 GOA
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

CARD8 蛋白结构

FIIND

FIIND: Function to find (182 - 437)

CARD

CARD: Caspase recruitment domain (452 - 534)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 500
  • 537 a.a.
蛋白主名 其他名称

caspase recruitment domain-containing protein 8

CARD inhibitor of NF-kappaB-activating ligands

关联疾病

疾病名称 别名
Inflammatory Bowel Disease 30

Inflammatory Bowel Disease 30

IBD30
Pharyngitis

Acute Pharyngitis

Chronic Pharyngitis

Acute Sore Throat

Chronic Sore Throat

Persistent Sore Throat

Pharyngeal Diseases

Chronic Pharyn/Nasopharyngitis

Chronic Pharyngitis And Nasopharyngitis

Inflamed Throat

Pharyngeal Disease

Pharyngeal Disorder

Pharyngitis - Acute

Sore Throat - Chronic

Acute Pharyngitis Nos

Acute Sore Throat Nos

Acute Throat Inflammation

Infective Pharyngitis

Infection Of Pharynx

Acute Infective Pharyngitis

Acute Infective Pharyngitis Nos

Acute Pharyngeal Inflammation

Inflammation Of The Throat

Throat Inflammation

Throat Infection

Putrid Pharyngitis

Pharyngeal Inflammation

Pharyngitis Nos

Chronic Throat Pain

Throat Catarrh
Arteriosclerosis Obliterans
Inflammatory Bowel Disease

Inflammatory Bowel Diseases

Bowel Disease, Inflammatory
Rheumatoid Arthritis

RA

Arthritis, Rheumatoid

Rheumatoid Arthritis, Susceptibility To

Arthritis Or Polyarthritis, Rheumatic

Atrophic Arthritis

Rheumatism Arthritis

Rheumatoid Polyarthritis
Cervical Adenitis

Cervical Lymphadenitis
Arthritis

Inflammatory Joint Disease

Inflammatory Disorder Of Joint
Anthracosis

Black Lung

Coal Workers' Pneumoconiosis

Melanoedema

Black Lung Disease

Pneumoconiosis

Coal Miner'S Pneumoconiosis

Coal Workers' Lung

Coal Worker'S Pneumoconiosis

Coal Workers Pneumoconiosis

Coal Miners' Lung

Coal Miners' Pneumoconiosis

Coal Pneumoconiosis

Colliers' Anthracosis

Colliers' Lung

Lung Melanosis

Miners' Asthma

Miners' Lung

Pneumomelanosis

Cwp - [Coalworkers Pneumoconiosis]

Fibrosis Of Lung With Anthracosilicosis

Lung Fibrosis With Anthracosis

Miners' Pneumoconiosis

Carbon Lung

Coalworker Lung

Collier'S Asthma

Anthracosilicosis

Lung Anthracosis
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Pre-clinical Phase
生物活性分子 (1)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS01922 CARD8 Human Pre-designed siRNA Set A Pre-designed Set / 否

直系同源

种属 基因名 来源 基因 ID
Felis catus CARD8 VGNC VGNC:60368
Rattus norvegicus CARD8 RGD RGD:1593294
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