2. Gene
  3. SBNO2 - strawberry notch homolog 2 Gene

SBNO2 - strawberry notch homolog 2 Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：草莓缺口同系物 2

种属: Homo sapiens

同用名: SNO; STNO; KIAA0963

基因 ID: 22904 | 基因类型: protein coding

关于 SBNO2

Cytogenetic location: 19p13.3 Genomic coordinates (GRCh38): 19:1,107,638-1,174,268 (from NCBI)

This gene has 10 transcripts (splice variants), 1 gene allele, 215 orthologues and 1 paralogue. Ubiquitous expression in appendix (RPKM 17.5), spleen (RPKM 13.1) and 25 other tissues.

功能概要

预测启用染色质 DNA 结合活性和组蛋白结合活性。参与多个过程，包括细胞对 interleukin-6 的反应；参与免疫反应的巨噬细胞激活；和转录的负调控，DNA 模板。预计活跃于核心。 [由基因组资源联盟提供，2022 年 4 月]

Predicted to enable chromatin DNA binding activity and histone binding activity. Involved in several processes, including cellular response to interleukin-6; macrophage activation involved in immune response; and negative regulation of transcription, DNA-templated. Predicted to be active in nucleus. [provided by Alliance of Genome Resources, Apr 2022]

SBNO2 基因产物(2)

mRNA Protein Name
NM_001100122.2 NP_001093592.1 protein strawberry notch homolog 2 isoform 2
NM_014963.3 NP_055778.2 protein strawberry notch homolog 2 isoform 1
基因本体论
  • 生物过程
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in cellular response to interleukin-6 IDA
IDA: 通过直接分析推断
25903009 GOA
involved in macrophage activation involved in immune response IMP
IMP: 通过突变表型推断
18025162 GOA
involved in negative regulation of DNA-templated transcription IMP
IMP: 通过突变表型推断
18025162 GOA
involved in regulation of inflammatory response IMP
IMP: 通过突变表型推断
18025162 GOA
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

SBNO2 蛋白结构

AAA_34

AAA_34: P-loop containing NTP hydrolase pore-1 (214 - 505)

Helicase_C_4

Helicase_C_4: C-terminal domain on Strawberry notch homologue (732 - 1010)

  • 0
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  • 1200
  • 1366 a.a.
蛋白主名 其他名称

protein strawberry notch homolog 2

关联疾病

疾病名称 别名
Inflammatory Bowel Disease

Inflammatory Bowel Diseases

Bowel Disease, Inflammatory
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Pre-clinical Phase
生物活性分子 (1)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS12470 SBNO2 Human Pre-designed siRNA Set A Pre-designed Set / 否

直系同源

种属 基因名 来源 基因 ID
Canis familiaris SBNO2 VGNC VGNC:45885
Rattus norvegicus SBNO2 RGD RGD:1307194
Felis catus SBNO2 VGNC VGNC:82408
Mus musculus SBNO2 MGD MGI:2448490
Macaca mulatta SBNO2 VGNC VGNC:77123
Bos taurus SBNO2 VGNC VGNC:34309
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