2. Gene
  3. PDZD2 - PDZ domain containing 2 Gene

PDZD2 - PDZ domain containing 2 Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：含 PDZ 结构域 2

种属: Homo sapiens

同用名: AIPC; PIN1; PAPIN; PDZK3

基因 ID: 23037 | 基因类型: protein coding

关于 PDZD2

Cytogenetic location: 5p13.3 Genomic coordinates (GRCh38): 5:31,639,131-32,110,932 (from NCBI)

This gene has 12 transcripts (splice variants), 230 orthologues and 1 paralogue. Biased expression in fat (RPKM 15.3), ovary (RPKM 9.0) and 12 other tissues.

功能概要

由该基因编码的蛋白质包含六个 PDZ 结构域，并与 pro-interleukin-16 (pro-IL-16) 具有序列相似性。与 pro-IL-16 一样，编码的蛋白质定位于内质网，并被认为被半胱天冬酶切割以产生含有两个 PDZ 结构域的分泌肽。此外，该基因在原发性前列腺肿瘤中上调，可能参与前列腺肿瘤发生的早期阶段。[RefSeq 提供，2015 年 12 月]

The protein encoded by this gene contains six PDZ domains and shares sequence similarity with pro-interleukin-16 (pro-IL-16). Like pro-IL-16, the encoded protein localizes to the endoplasmic reticulum and is thought to be cleaved by a Caspase to produce a secreted peptide containing two PDZ domains. In addition, this gene is upregulated in primary prostate tumors and may be involved in the early stages of prostate tumorigenesis. [provided by RefSeq, Dec 2015]

PDZD2 基因产物(1)

mRNA Protein Name
NM_178140.4 NP_835260.2 PDZ domain-containing protein 2
基因本体论
  • 细胞组分
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in cytoplasm IDA
IDA: 通过直接分析推断
11289102 GOA
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

PDZD2 蛋白结构

PDZ

PDZ: PDZ domain (Also known as DHR or GLGF) (338 - 415)

PDZ

PDZ: PDZ domain (Also known as DHR or GLGF) (590 - 664)

PDZ

PDZ: PDZ domain (Also known as DHR or GLGF) (752 - 810)

PDZ

PDZ: PDZ domain (Also known as DHR or GLGF) (2624 - 2692)

PDZ

PDZ: PDZ domain (Also known as DHR or GLGF) (2756 - 2833)

  • 0
  • 500
  • 1000
  • 1500
  • 2000
  • 2500
  • 2839 a.a.
蛋白主名 其他名称

PDZ domain-containing protein 2

PDZ domain-containing protein 3

关联疾病

疾病名称 别名
Motility-Related Diarrhea
Sacral Defect With Anterior Meningocele

Caudal Regression Syndrome

Caudal Regression Sequence

Sacral Agenesis

Caudal Dysgenesis Syndrome

SDAM

Caudal Dysplasia Sequence

Caudal Dysplasia

Sacral Agenesis Syndrome

Sacral Regression Syndrome

Sacral Defect And Anterior Sacral Meningocele

Rudd Klimek Syndrome

Sirenomelia
Prostate Cancer

Prostate Carcinoma

Prostate Cancer, Familial

Prostate Neoplasm

Prostate Cancer, Somatic

Prostate Cancer, Susceptibility To

Prostatic Cancer

Prostatic Neoplasms

Hereditary Prostate Cancer

Prostatic Neoplasm

Cancer Of Prostate

Carcinoma Of Prostate

Familial Prostate Cancer

Familial Prostate Carcinoma

Malignant Tumor Of Prostate

Malignant Neoplasm Of Prostate

Prostate Cancer, Familial, Susceptibility To

Malignant Tumor Of The Prostate

Ngp - New Growth Of Prostate

Tumor Of The Prostate

Prostate Cancer, Hereditary

Cancer Of The Prostate

Malignant Neoplasm Of The Prostate

Prostatic Carcinoma

PC

Prca

Cancer, Prostate

Malignant Prostatic Tumour

Malignant Tumour Of Prostate

Primary Prostate Cancer

Primary Malignant Neoplasm Of Prostate

Prostate Gland Cancer
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Pre-clinical Phase
生物活性分子 (2)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS10301 PDZD2 Human Pre-designed siRNA Set A Pre-designed Set / 否
HY-RS22716 Pdzd2 Mouse Pre-designed siRNA Set A Pre-designed Set / 否

直系同源

种属 基因名 来源 基因 ID
Mus musculus PDZD2 MGD MGI:1922394
Bos taurus PDZD2 VGNC VGNC:32725
Rattus norvegicus PDZD2 RGD RGD:619958
Felis catus PDZD2 VGNC VGNC:64100
Macaca mulatta PDZD2 VGNC VGNC:75829
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